Modafinil is a wakefullness promoting medication used to treat individuals suffereing from excessive sleep disorders and Narcolepsy. It increases a patients wakefullness and helps individuals that take it to stay awake and reduce the likelihood of suffering a sleep attack

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What is Modafinil

Modafinil, which is also sold under the branded name of Provigil, is a drug which combats excessive tiredness. It increases a patients’ wakefulness by stimulating a part of your brain, and so help those taking it to stay awake. Modafinil is commonly prescribed for patients who suffer with Narcolepsy which can cause someone to feel excessively tired and fall asleep without control during the daytime or at inappropriate moments. Although there are some other techniques those suffering from narcolepsy may be able to adopt in order to promote wakefulness, your doctor may prescribe you Modafinil in order to improve your Narcolepsy and reduce the likelihood of suffering a sleep attack.

Due to its properties of stimulating wakefulness, Modafinil may also be prescribed to treat Shift Work Sleep Disorder and excessive sleepiness caused by obstructive sleep apnea.

It is unknown exactly how this medicine promotes wakefulness, however, doctors think that it may be responsible for increases your levels of dopamine which is a chemical neurotransmitter nerves use to communicate with one another. It may increase the levels of these neurotransmitters by decreasing the rate in which dopamine is absorbed into the nerves.

Modafinil Dosage

Modafinil is commonly prescribed by doctors in 100mg or 200mg strength dosages. It is generally recommended to take a dose of 200mg once a day.

Modafinil 100mg

This is the lowest dosage of Modafinil available. Generally, Modafinil 100mg strength is prescribed for patients over 65 years to commence their course. This dosage may be increased if it is not effective in treating symptoms. Those who suffer with severe kidney problems will also be prescribed this lower strength.

Modafinil 200mg

This strength dosage of Modafinil is perhaps the most widely prescribed to treat excessive sleep disorders. It is important you do not exceed this dosage unless you have been advised by your doctor. Modafinil 200mg can be used to treat a variety of sleep disorders as well as treating adults who suffer from excessive sleepiness. The recommended starting dosage is 1 x Modafinil 200mg tablet per day

Modafinil 400mg

400mg is the strongest dose of Modafinil available. Usually, this strength is only administered by doctors after review of taking a course of 200mg. If the 200mg strength is found to have not alleviated a patients’ sleepiness, then a doctor may then increase the dosage strength to 400mg.

Modafinil mechanism of action and how to take

Doctors will usually prescribe and advise patients to administer one Modafinil 200mg tablet per day. Generally, it should be taken in the morning to treat narcolepsy or obstructive sleep apnea. For those suffering with shift work disorder, the advice is to take Modafinil one hour before work.

If you will be taking Modafinil for a long-term solution to excessive tiredness, it is expected to be periodically re-evaluated by your doctor as it is unclear as of yet if Modafinil is efficient long term.

If you have forgotten to take a dose of Modafinil do not double up your consumption to make up for it. Take your next tablet at the usual time.

Please also note that Modafinil and a range of some other medicines, such as hormonal contraception, can effect the effectiveness of each other which may mean your doctor will have to adjust the strength of dosage you take. Ensure that you tell your doctor of all other medicines that you take during your consultation.

If you take more Modafinil than you have been recommended to consume you may feel: sick, disorientated or confused, restless, agitated/ anxious, have trouble sleeping, diarrhoea, hallucinations, chest pain, a change in heart beat rate or an increase in your blood pressure. You must contact your nearest hospital or your doctor immediately if you experience any of these symptoms. If you are asked to go and see a medical advisor, you should take any remaining tablets with you.

Below are the Modafinil dosage recommendations your doctor may advise you to follow in accordance with your condition:

  • Excessive sleepiness associated with narcolepsy with or without cataplexy

Your doctor will normally begin your treatment course with a Modafinil 200mg dose divided into two 100mg tablets, one to be taken in the morning and one at noon. Alternatively, your doctor may recommend you to take just one Modafinil 200mg tablet per day to be consumed in the morning.

  • If you are 65 years or over, or suffering from liver or kidney problems

It is to be expected that you will be initially prescribed to take Modafinil 100mg once daily.

Modafinil Side Effects 

As with all medicines you may experience some potential side effects. The list below is not exhaustive, please check your medicines leaflet for a full list of all possible side effects. If you begin to experience any of the following symptoms you must stop taking Modafinil and contact your doctor or pharmacist.

        Common Side Effects

  • Abdominal pain
  • A change in appetite
  • Anxiety, confusion, depression
  • Asthenia
  • Chest pains
  • Constipation or diarrhoea, Dizziness
  • Drowsiness, Sleep Disturbances
  • Dry mouth
  • Indigestion or Gastrointestinal Disturbances
  • Headache
  • Nausea
  • Palpitation
  • A tingling, numbness or burning sensation of the skin
  • Increase in heart rate or more noticeable heart palpitations
  • Visual Disturbances

Uncommon Side Effects

  • Abnormal dreams, amnesia
  • Acne, skin rash or itchy skin
  • Increased sweating
  • Aggression
  • Agitation
  • Back, neck, muscle pain or weakness
  • A spinning sensation (Vertigo)
  • Difficulty moving muscles smoothly
  • Hay fever symptoms of runny/ itchy nose or watery eyes
  • Difficulty swallowing, swollen tongue or mouth ulcers
  • Excess wind, reflux, an increase in appetite, a change in weight, thirstiness or a change in the sensation of taste
  • Shortness of breath, asthma or cough
  • Vomiting
  • Migraine
  • Speech problems
  • Diabetes, high blood cholesterol, changes in blood pressure, abnormal heart trace
  • Swollen extremities such as your hands and feet
  • A loss of your libido
  • Symptoms of sinusitis such as a nose bleed, sore throat or inflamed nasal passages
  • Abnormal vision or dry eyes
  • More frequently urinating or abnormal periods
  • Restlessness

In rare cases patients taking Modafinil can suffer from a severe allergic reaction to the medicine. If you experience any of the warning symptoms you MUST contact an emergency service such as 111 or 999 immediately. The signs of a severe allergic reaction are:

  • Developing a skin rash which is itchy, red, swollen, blistered or peeling
  • Your chest or throat feeling tight. This can also be displayed through wheezing.
  • Experiencing difficulty in breathing or talking
  • Your facial extremities become swollen i.e. you mouth, face, lips, tongue or throat.

How can I buy Modafinil online in the UK?

If you are a valid UK citizen and have a prescription from a doctor, you will be able to purchase Modafinil online in the UK with us, Medicine Direct. If you do not yet have a prescription for Modafinil, you can fill in one of our health questionnaires which will be reviewed by one of our doctors. After assessing your answers, the doctors will then prescribe you the medicine if they decide it appropriate to do so.

You can buy Modafinil online if you are suffering from one of the conditions listed above. In order to receive the correct dosage of modafinil, we ask that you provide our online doctor with as much information regarding your condition as possible, including side effects experienced and if you have used the drug previously and how effective it proved to be in treating your condition.

What does Modafinil do?

It is thought that Modafinil acts as an amphetamine in that it may work to modify neurotransmitters in the brain to decrease the rate in which they absorb dopamine.

What is Modafinil prescribed for in the UK?

Modafinil is commonly prescribed for the treatment of excessive sleepiness disorder such as narcolepsy, shift work sleep disorder or excessive daytime sleepiness. It is administered to reduce the likelihood of the patient suffering from a sleep attack, i.e. falling asleep without control during an inappropriate situation.

Is it safe to take Modafinil if you are pregnant or breastfeeding?

It is unclear if Modafinil effects pregnancy of if it is excreted into the milk. Please discuss whether you are pregnant, breastfeeding or trying to conceive a baby with your doctor before being prescribed Modafinil. As there is little available data, it is recommended for women who are pregnant or breastfeeding to not take this medicine.

Can Modafinil cause you to lose weight?

For some people Modafinil can act to suppress appetite which has shown in studies that those who take Modafinil may lose weight.

Can you drink alcohol whilst taking Modafinil?

It is advised that you should avoid drinking alcohol whilst taking Modafinil. Taking Modafinil and alcohol together can reduce the effectiveness of the medication as well as increase your risk of experiencing the side effects associated with the medicine.

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