• Replaces the bodys natural level of Oestrogen
  • Relieves the symptoms of Menopause
  • Protects against Osteoporosis
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What is Premarin?

Premarin 0.625mg, 0.3mg & 1.25mg tablets are a form of hormone replacement therapy (HRT) that are taken by women to relieve the symptoms and conditions that often come with the menopause. These tablets contain oestrogen, which is a female hormone.

How can I buy Premarin online safely?

Premarin is only available to purchase when you have been given a prescription. You can buy Premarin tablets online from Medicine Direct after you have completed a simple and confidential online consultation with one of our registered doctors or pharmacist.

Just complete a short questionnaire about your medical history and condition, and you will be prescribed this medicine if it is suitable for you. You can then order it from our UK-based online pharmacy. We offer next day delivery on any order that is placed by 2pm.

Medicine Direct is registered with the General Pharmaceutical Council (GPhC), which means we can guarantee all medication sold on our site is approved and safe to use.

What are the benefits of taking Premarin?

Premarin tablets are an effective medication for relieving various symptoms of the menopause.

This hormone replacement therapy treatment is normally prescribed for women who have had a hysterectomy (removal of the womb), although women who still have their womb can also be prescribed Premarin.

All women will go through the menopause, which usually starts between the ages of 45 and 55. During the menopause the ovaries gradually stop producing the female sex hormone oestrogen. The lack of oestrogen in a woman's body can cause various symptoms, such as depression, dryness, hot flushes and osteoporosis.

Premarin tablets work by boosting your oestrogen levels, which helps to alleviate the symptoms associated with the menopause. This medicine also helps to prevent osteoporosis (fragile bones) after the menopause.

Non-medicinal alternatives for the symptoms of menopause

Various techniques exist to alleviate the symptoms of menopause.

For example, to help with hot flushes, women can try cold showers, wearing light and loose-fitting clothing and using a fan.

Lubricants are useful for alleviating vaginal dryness.

Other alternatives

Giving up smoking, aside from improving your overall health, can be highly beneficial for easing menopause symptoms.

Eating a balanced diet and taking regular exercise can also improve your mood, physical fitness and improve the symptoms of the menopause.

Who can use Premarin?

Premarin is not a suitable form of hormone replacement therapy for all women to use.

Do not take Premarin if any of the following apply to you:

  • You are allergic to conjugated estrogens or any other ingredient contained in this medication (please refer to the Ingredients tab for full details)
  • You have or have ever had a liver disease
  • You have any unexplained vaginal bleeding
  • You have ever had a blood clot in a vein, such as in the leg, lung or other organ
  • You have a blood clotting disorder
  • You have the inherited blood problem porphyria
  • You are pregnant or breastfeeding
  • You have breast cancer, have ever had it or are suspected of having it
  • You have or have recently had any disease that was caused by blood clots in the arteries, such as a heart attack, angina or stroke
  • You have or are suspected of having a form of cancer that is sensitive to oestrogens, such as cancer of the womb lining
  • You have untreated excessive thickening of the lining of the womb


If you get any of the above conditions for the first time while taking this medication, stop taking it and speak to your doctor.

If you have ever had any of the problems listed below, speak to your doctor or pharmacist before you start using Premarin:

  • Endometriosis or a history of excessive growth of the womb lining
  • You are at an increased risk of developing blood clots
  • Fibroids inside the womb
  • A high risk of getting an oestrogen-sensitive cancer, such as having a mother or grandmother who suffered from breast cancer
  • Gallstones or gallbladder disease
  • Asthma
  • Epilepsy
  • High blood pressure
  • Diabetes
  • Severe headaches or migraine
  • A liver disorder
  • Kidney disease
  • Heart disease
  • Systemic lupus erythematosus (SLE)
  • Otosclerosis
  • Hypocalcaemia
  • High levels of fat in your blood
  • Fluid retention as a result of kidney or cardiac problems


Always read the patient information leaflet for complete information on who may not be suitable to take Premarin. If you are unsure, speak to your doctor or pharmacist before you start taking it.

Possible side effects

Like all medicines, Premarin can cause side effects, although they will not affect everyone who takes it.

Women who take HRT like Premarin have reported the following side effects:

  • Leg cramps, joint pain
  • Painful, swollen or tender breasts, changes in the breast tissue, nipple discharge
  • Dizziness
  • Mood changes, including anxiety and depression
  • Migraine or headache
  • Nausea/vomiting, abdominal pain and feeling bloated
  • Being more prone to thrush
  • Abdominal uterine bleeding such as breakthrough bleeding or spotting, changes in menstrual flow, unusual vaginal discharge, pelvic pain or vaginal inflammation
  • Increased or decreased interest in sex
  • Memory loss
  • Asthma getting worse
  • Intolerance to glucose
  • Weight gain or weight loss
  • Rash, acne, dark/red patches on the skin, itchiness
  • Swelling of the face or ankles
  • Changes in triglyceride levels
  • Hair loss or increased hair growth
  • A benign meningioma
  • Jaundice or gallbladder disease
  • Symptoms of angioedema getting worse or appearing for the first time
  • Worsening of chorea
  • Minor changes to the eyes
  • Colon inflammation


These side effects are normally only temporary and generally improve in time. Speak to your doctor if any of the reactions listed above bother you or do not go away.

This list is not exhaustive. Please see the Side Effects tab for more details; always read the patient information leaflet for comprehensive details on side effects.

Premarin Dosage 

How do I take Premarin?

Our pharmacists and prescribers follow NICE guidelines when prescribing Premarin.

Always take Premarin as your doctor or pharmacist has told you. Read the patient information leaflet and ask your doctor or pharmacist for guidance if you are not sure.

The normal dose of Premain is to take one tablet every day. To ensure you do not forget to take the tablet, take it at the same time every day.

Swallow the tablets whole with a drink of water. Do not open, crush or chew them.

You will be prescribed the lowest dose possible for the shortest time possible to effectively treat your symptoms. If you think that your dose is too strong or not strong enough, speak to your doctor or pharmacist about it.

If you are not already using another form of hormone replacement therapy, or you are taking a HRT treatment that does not give you monthly bleed, you can start taking Premarin at any time.

If you are changing over from an HRT medication that gave you a monthly bleed, start taking Premarin the day after you finish the previous course of medication, unless your doctor/pharmacist instructs you to do otherwise.

Once you start taking Premarin, you should take it continuously; once you have finished one pack of tablets, begin the next pack the very next day without a break.

What if I forget to take it?

If you miss a dose of Premarin, just take the missed dose as soon as you remember, then continue to take the tablets as usual.

Do not take a double dose to try and make up for missing a previous one.

If you miss a dose and have not had a hysterectomy, you may experience a short period of light vaginal bleeding.

What if I take too much?

Taking an extra dose of Premarin is unlikely to cause you any harm. However, you may experience breast tenderness, nausea, abdominal pain, dizziness or drowsiness.

Women who have taken too much and have not had a hysterectomy may also have a short period of vaginal bleeding.

Talk to your doctor or pharmacist if you become worried or have taken more than one extra dose.

How do I buy Premarin online?

Premarin is only available to buy when you have been prescribed it by a registered health professional. To order Premarin from Medicine Direct, all you need to do is complete a simple and confidential online consultation with one of our certified doctors or pharmacists. After reviewing your answers and assessing your medical history, they will give you a prescription to purchase Premarin if they find it safe to do so. With this prescription, you can order your medication from our online pharmacy the very same day. If you place your order by 2pm, we can also offer you next day delivery. Never purchase any form of medicine online unless it is from a UK-registered pharmacy that is regulated by the General Pharmaceutical Council (GPhC), like Medicine Direct. Every member of our medical team possesses experience in working in a professional clinic setting, such as an NHS hospital. They are all registered with the General Pharmaceutical Council, General Medical Council (GMC) and the MHRA,meaning they are legally qualified to prescribe medicine just like your local GP.

What does the price include?

The price includes the cost of the medication itself, an online consultation with a registered health professional and postage, which will either be via DPD or Royal Mail, depending on the option you select.

What are the advantages of buying Premarin online?

Buying Premarin online comes with various advantages. It means that you do not need to leave the house to see your local doctor; instead, you can be seen straight away by a medical professional, from the comfort of your own home. You do not need to wait for days to get an appointment with your local GP. Ordering from Medicine Direct means you are able to speak to a registered doctor or pharmacist immediately. Just complete a simple and private online consultation and you will be prescribed an appropriate course of medicine. Furthermore, if you order by 2pm, we can have your medication with you the very next day. This means you can start your course of treatment almost immediately.

Premarin Side Effects

Stop using Premarin and seek medical attention immediately if you notice any of the following:

  • Any signs of blood clots (sudden chest pain, breathing problems, painful swelling an redness of the legs)
  • You become pregnant
  • You develop any of the conditions listed in the 'Who can use Premarin?' section
  • You develop high blood pressure (symptoms can include tiredness, headaches and dizziness)
  • You get yellowing of the skin or the whites of the eyes (these may be signs of a liver disease)
  • You get migraine-like headaches which did not happen before you started taking this medication
  • You have signs of a serious allergic reaction (see below for full details)


Serious allergic reaction

If you notice any of the symptoms listed below, you may be having a serious allergic reaction to Premarin and require urgent treatment in hospital.

Call 999 or go to A&E straight away if:

  • You get a skin rash that may include red, itchy, swollen, blistered or peeling skin
  • You are wheezing
  • You have tightness in your chest or throat
  • You have swelling in your face, mouth, tongue, lips or throat
  • You are finding it difficult to breathe or speak


Always read the patient information leaflet for full details on side effects. Speak to your doctor or pharmacist if you are worried.


Premarin Warnings

Before you start using Premarin, it is important to inform your doctor or pharmacist if you are already using any other medicine. This includes prescription and non-prescription medication, herbal remedies, vitamins and supplements.

In particular, make sure your doctor or pharmacist is aware if you are already taking any of the below:

  • Herbal remedies, such as St. John's wort
  • Metyrapone
  • Any anticonvulsant medicines
  • An anti-infective medicine
  • Cimetidine
  • The corticosteroid dexamethasone
  • Any antibiotics or anti-fungal medications

For more on medicines that interact with Premarin.

You are advised to not drink grapefruit juice while taking this medicine, as it may interfere with how Premarin works.

Premarin contains the sugars Lactose monohydrate and sucrose. Speak to your doctor or pharmacist before using this medicine if you have been told that you are intolerant to some sugars.

Yellow Premarin tablets also contain E110 (sunset yellow), which is a colouring agent. This may cause allergic reactions in some people.

The following conditions are reported more frequently in women who are using HRT compared to those who are not:

  • Ovarian cancer
  • Stroke
  • Heart disease
  • Breast cancer
  • Cancer or abnormal growth of the womb lining
  • Blood clots in vein of the legs or lungs
  • Likely memory loss if HRT begins over the age of 65


Premarin is not a contraceptive pill. You may still need to use contraception if it has been less than 12 months since your final period or you are under the age of 50. Your doctor or pharmacist will be able to advise you about this.

Always read the patient information leaflet for full details on warnings and drug interactions. Speak to your doctor or pharmacist if you have any questions or concerns.

Pregnancy and breastfeeding

Premarin is not indicated for use during pregnancy.

If you are breastfeeding speak to you doctor before taking premarin, as your doctor will assess the risk factors of taking this medication during this time. 


Premarin Ingredients

The active ingredient contained in Premarin tablets is a mixture of hormones known as conjugated oestrogens.

The other ingredients are: lactose monohydrate, microcrystalline cellulose, magnesium stearate, hypromellose, sucrose, hydroxypropyl cellulose, macrogol, carnauba wax, edible ink and coating.

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Written byHussain Abdeh MPharm: 2211840

Published on: 12/10/2020

Updated on: 03/06/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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