Xifaxanta (Rifaximin) 200mg Tablets

  • Effective treatment for Travellers' Diarrhoea
  • Stops bacteria growth, allowing the immune system to fight the remaining bacteria
  • Can be used for up to three days
From As low as £28.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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What is Xifaxanta?

Xifaxanta is a prescription-only medicine (POM) that is taken by adults over 18 years old to treat travellers' diarrhoea.

It contain an intestinal antibiotic medicine as its active ingredient and can be used for up to three days.

You can buy Xifaxanta tablets online from Medicine Direct when you have been given a prescription by one of our registered doctors or pharmacists. Just complete our confidential online consultation form and you will be issued a prescription to purchase this treatment from our UK registered online pharmacy.

Always check the Fit For travel website to ensure you are ordering the correct medication for your travels. 

How does Xifaxanta work? 

Xifaxanta 200mg tablets are prescribed to treat the symptoms of travellers' diarrhoea in adults.

You will be given a prescription for this treatment if you are suffering from diarrhoea that has not been accompanied by blood in the stools, a fever, or 8 or more liquid stools in the past 24 hours.

It can be taken by adults over the age of 18 years old.

Xifaxanta 200mg tablets work within your gut and are not absorbed into the bloodstream. Rifamixin is an antibiotic medicine that inhibits an enzyme in bacteria called RNA-polymerase from being produced. This works to stop it from growing, allowing your immune system to kill off the remaining bacteria.

What is travellers' diarrhoea?

Travellers' diarrhoea is a condition that occurs mostly when visiting a foreign country, and is most commonly the result of eating or drinking something that is contaminated. It is a relatively common illness, affecting between 30% and 50% of travellers to tropical locations. The majority of cases are caused by bacterial infections, although this problem can also be caused by a virus or parasite.

As the name suggests, diarrhoea is the most common symptom of this problem. However, you may also experience headache, stomach pain, loss of appetite and nausea.

To stand the best chance of avoiding this problem while abroad, you should only drink bottled water and not drink from the tap. Also, avoid drinks with ice cubes, as the ice has often been made from tap water. You should also only eat food that has been properly cooked.

If you do suffer from diarrhoea, it is important that you keep hydrated, as your body loses a lot of vital fluids through excessive and watery bowel movements.

Is Xifaxanta suitable for me?

Xifaxanta may not be suitable for you if any of the following apply to you.

These tablets must not be taken by children under the age of 18.

Do not take Xifaxanta if:

  • You are allergic to rifamixin or any of the other ingredients contained in this medication (please refer to the Ingredients tab for full details)
  • You are suffering from constipation, abdominal pain and vomiting caused by a blockage in the bowel
  • You have blood in your stools
  • You have a fever
  • You have passed 8 or more liquid/soft stools in the past 24 hours

Talk to your doctor or pharmacist if:

  • Your symptoms get worse while using this treatment (if this happens stop taking the tablets and speak to your doctor or pharmacist again)
  • You have been taking Xifaxanta for 3 days and your symptoms have not gone away or have returned. If this happens, do not start taking the tablets again. Speak to your doctor or pharmacist.

Possible side effects

Like all medicines, Xifaxanta can cause side effects, although not everyone suffers from them.

Common side effects may occur in up to 1 in 10 people:

  • Headache
  • Fever
  • Wind, abdominal pain, abdominal bloating, diarrhoea, nausea, urgently needing to empty your bowels, vomiting, involuntary and painful or ineffective straining

The following side effects are uncommon and may occur in up to 1 in 100 users:

  • Sunburn
  • Double vision
  • Abnormal test results in white blood cells
  • Frequent periods
  • Hot flushes
  • Cough, dry throat, sore throat, runny nose, blocked nose
  • Earache, vertigo
  • Sleeplessness, nervousness, abnormal dreams, depressed mood
  • Frequent or excessive urination
  • Blood in urine, sugar in urine, protein in urine, abnormal urine test results
  • Sinus headache, pins and needles, numbness, drowsiness
  • Thrush, cold sores, inflamed or infected nose or throat
  • Loss of appetite, dehydration
  • Muscle cramps, back pain, muscle pain, neck pain, muscle weakness
  • Increased liver enzyme values in blood test results
  • Flu-like symptoms, pain, increased sweating, chills, cold sweat

Please speak to your doctor or pharmacist if any of these reactions bother you or do not go away. Please refer to the Side Effects tab for information.


Xifaxanta Dosage and Directions

Our pharmacists and prescribers follow NICE guidelines when prescribing Xifaxanta Tablets.

To provide effective relief from diarrhoea, take Xifaxanta 200mg tablets exactly as your doctor or pharmacist has instructed you. Read the patient information leaflet for full instructions and ask your doctor or pharmacist for further guidance if you need it.

Each blister pack of Xifaxanta contains 9 tablets. Unless your doctor or pharmacist tells you otherwise, the usual dose is to take one tablet every 8 hours. Keep taking the tablets for three days, even if your symptoms have gone away.

Swallow the tablets whole with a drink of water. Do not crush or chew the tablets. Xifaxanta tablets can be taken with or without food.

Do not keep taking Xifaxanta tablets for longer than three days. If you still have diarrhoea after three days, speak to your doctor or pharmacist.

What if I forget take it?

If you forget to take Xifaxanta, take the dose you missed as soon as you remember. Then continue to take your tablets at the usual times.

Do not take a double dose to make up for missing an earlier one.

What if I take more than I am supposed to?

Call 111 or contact your doctor or pharmacist if you have taken more tablets than you were supposed to.

Can I use this treatment for other types of infection?

No, these tablets are only used to treat infections in the gastrointestinal system. Because it is not absorbed into the body like many other antibiotics, it is not a suitable treatment for different infections.

Is Xifanta suitable for everyone?

Xifaxanta is not a suitable medicine for everyone to take. It must not be taken by children. If you have diarrhoea with a fever or blood in your stools, you should not use Xifaxanta to treat the problem. Refer to the patient information leaflet for full details on who should not use this medicine.

How do I use this medicine?

Take one tablet every 8 hours for a maximum of 3 days. If you are still suffering with symptoms after 3 days, speak to your doctor or pharmacist; do not continue using this medication. Swallow the tablets whole with a drink of water. They can be taken with or without food.

What other measures can I take to feel better?

It is important to remember to stay hydrated while suffering from diarrhoea, as this condition can cause your body to lose a lot of fluid. When you are able to eat, stick to plain foods and avoid things that are spicy or fatty.

At what point should I see a doctor?

See a doctor if your symptoms get worse or have not improved after taking Xifaxanta 200mg tablets for three days.

Can I drink alcohol while using Xifaxanta tablets?

Drinking alcohol while suffering from travellers' diarrhoea may make the condition worse.

Can I drive while using Xifaxanta tablets?

Xifaxanta should not impair your ability to drive. However, if you suffer from any side effects that make it harder for you to drive, you should not drive, cycle or operate any machines until you feel better.

Can I use Xifaxanta tablets if I am pregnant?

Do not use this medicine if you are pregnant or breastfeeding. Seek medical attention if you suffer from travellers' diarrhoea during pregnancy.

How should Xifaxanta tablets be stored?

Store these tablets out of the sight and reach of children. This medication does not require any special storage conditions, but you must not use it if the medicine has passed its expiry date. This can be found on the packaging.

Are Xifaxanta tablets available over-the-counter?

No, you must have a prescription to purchase this medication. You can obtain a prescription to order Xifaxanta from Medicine Direct by completing an online consultation. One of our registered prescribers will issue you with a prescription to order this medicine if they deem it suitable for you to use. Never order any medicine, prescription or non-prescription, from anywhere other than a UK-registered pharmacy, like Medicine Direct.

Xifaxanta Side Effects

The following side effects may affect some people. However, it is not possible to estimate how frequently they may occur:

  • Bacterial infections
  • Allergic reaction (see below for more information)
  • Abnormal blood test results
  • Roughness or redness of the skin, small purple spots forming on the skin

Seek medical attention if any of these side effects bother you .

Serious allergic reaction

If you get any of the symptoms listed below, you might be suffering from a serious allergic reaction, which could require immediate treatment in a hospital.

Stop taking Xifaxanta and go to A&E or call 999 immediately if you notice any of the following:

  • You are finding it hard to speak or breathe
  • You are wheezing
  • You develop a skin rash that may include red, itchy, swollen, blistered or peeling skin
  • You have tightness in your throat or chest
  • Your mouth, tongue, throat, lips or face starts to swell
  • You have a racing heart
  • You feel extremely tired, dizzy or faint


Always read the patient information leaflet for comprehensive details on side effects. If you have any concerns or questions about the side effects associated with this medicine, please discuss your concerns with your doctor or pharmacist before you start treatment.

Xifaxanta Warnings

Cautions with other medicines

Before you start to take Xifaxanta, you must tell your doctor or pharmacist if you are already using (or have recently used) any other prescription or non-prescription medication. This includes herbal remedies, vitamins and supplements.

It is particularly important that you tell them if you are taking a medicine to suppress the body's immune system called ciclosporin, a medicine to prevent blood clotting called warfarin, or any oral contraceptives to prevent pregnancy as these medicines can interact with Xifaxanta.

If you are taking activated charcoal, take Xifaxanta at least 2 hours after you have taken the charcoal.

Driving and using machines

Xifaxanta is unlikely to impair your ability to drive or use any machines. However, if you experience any side effects that impair your ability to see or think clearly (such as such as double vision, sleepiness or vertigo), you must not drive, cycle or operate machinery until you feel better. If these symptoms continue for longer than 24 hours, speak to your doctor as soon as possible.

Please read the patient information leaflet thoroughly before you start to take Xifaxanta. Here, you will find a complete list of warnings and drug interactions you will need to be aware of while using this treatment. If you have any questions or concerns, please discuss these with your doctor before beginning your course of treatment.

Pregnancy and breastfeeding

If you are pregnant or a fertile woman who is not using contraception, you should not use Xifaxanta.

Please ensure you tell your doctor or pharmacist if you are pregnant, trying to get pregnant, think you may be pregnant or are breastfeeding.

Always read the patient information leaflet, which will come with your medicine, for complete details on why this prescription treatment may not be suitable for you. If you still have any doubts, discuss them with your doctor or pharmacist before you start to take the medication.

Xifaxanta Ingredients

Xifaxanta 200mg tablets contain the active ingredient rifamixin.

The following inactive ingredients are also contained: sodium starch glycolate type A, glycerol distearate, colloidal anhydrous silica, talc, microcrystalline cellulose. Tablet coating: hypromellose, titanium dioxide E171, disodium edetate, propylene glycol and red iron oxide E172.

Each blister pack contains 9 tablets.

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

This page has recently been medically reviewed by Hussain Abdeh MPharm: 2211840

Updated on: 07/06/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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