Estriol Cream

  • Helps to treat the vaginal symptoms of menopause
  • Cream must be applied daily for full benefits
  • Comes with applicator for ease of use
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From As low as £49.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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What is Estriol Cream?

Estriol cream is a hormone replacement therapy (HRT), prescribed to treat the symptoms of the menopause.

It is used to replace the oestrogen that is lost naturally during the menopause. This helps to alleviate discomfort in the vagina.

You must have a prescription to buy Estriol cream.

What is Estriol Cream used to treat?

Women who use Estriol cream do so to relieve the vaginal symptoms of the menopause.

When a woman goes through the menopause, the levels of oestrogen in her body will drop significantly. This may lead to problems like vaginal dryness, inflammation and pain during sexual intercourse.

The menopause is a natural transition that occurs in all women. For most women, it will start between the ages of 45 and 55 and will normally last for around four years after their final menstrual cycle. The symptoms, however, can start well before your last period.

The menopause occurs because women’s ovaries gradually start to produce less hormones as they age. This means that their oestrogen levels can rise and fall.

As a result, women can suffer symptoms such as discomfort or pain during sex, as well as vaginal dryness or itching. A hormone replacement therapy (HRT) cream like Estriol helps to combat this.

How does Estriol work?

Estriol is a mild oestrogen, meaning this cream helps to boost your oestrogen levels when you are going through the menopause.

Women who are experiencing menopause will suffer a decrease in the levels of oestrogen in their bodies, which can lead to a range of symptoms, such as vaginal dryness, inflammation and pain when you have sex.

By applying this cream, you are able to alleviate these symptoms, helping you to resume normal sexual activity and go about your daily life without pain or discomfort.

How to use Estriol

You should use Estriol cream in the evening.

  1. Wash your hands before applying the cream.
  2. Ensure the plunger is inserted into the applicator.
  3. Screw the end of the applicator to the top of the tube.
  4. Squeeze the tube to fill the applicator.
  5. Remove the applicator and replace the cap on the tube.
  6. Lie down and open your legs.
  7. Insert the applicator as far as is comfortable into your vagina and press down on the plunger. This releases the cream.
  8. Remove the applicator and rewash your hands.
  9. Wash the plunger and the applicator with soapy water to remove any cream.

Always read the patient information leaflet that comes with the cream for full instructions. Ask your doctor or pharmacist if you are unsure.

Who can use Estriol Cream?

Estriol cream is not suitable for everyone to use.

Speak to your doctor before using this medication if any of the following conditions affect you:

  • High blood pressure
  • Heart attack
  • Fibroids
  • Liver disease or any other liver problems
  • Migraines
  • Diabetes
  • Gallbladder problems
  • Mastopathy
  • Endometriosis or any other womb problems
  • Any blood clot problems or you are prone to blood clots
  • Porphyria
  • You have, think you may have, or have ever had, breast cancer
  • Epilepsy
  • Systemic lupus erythematosus
  • Asthma
  • Otosclerosis
  • Angioedema

Always read the patient information leaflet to see the full list of reasons why Estriol cream may not be suitable for you.

Possible side effects

As with any medication, Estriol cream comes with the risk of certain side effects, although not all women who uses it will suffer from them.

Speak to your doctor if any of these reactions bother you or do not go away:

  • Vaginal discharge
  • Breakthrough bleeding
  • Breast pain or tenderness
  • Feeling sick or being sick
  • Pre-menstrual tension syndrome (PMT)
  • Needing to urinate more often or pain when you urinate
  • Feeling bloated, stomach cramps or stomach pain
  • Patches or darkened skin, painful swelling or bruising in the legs, or small red marks on the skin
  • Faster or irregular heartbeats
  • Leg pain
  • Depression
  • Dementia (memory loss) over the age of 65

This list is not exhaustive. Please, refer to the Side Effects tab on this page for rarer, more serious reactions you may suffer.

Always read the patient information leaflet thoroughly before using a new medication.

Can you buy Estriol cream over the counter?

No, Estriol cream is a prescription-only medicine (POM), so not for sale over the counter.

Can you buy Estriol cream online in the UK?

You need to have been prescribed Estriol to be able to buy it in the UK. However, by completing an online consultation on our website, you can order Estriol cream from Medicine Direct. One of our doctors, pharmacists or prescribers will review your condition and the answers you provide in a private questionnaire to make sure Estriol is suitable for you.

Medicine Direct is a fully regulated UK pharmacy. Never buy any medication online from anywhere but regulated pharmacies.

Estriol cream alternatives

There are a wide range of HRT treatments available to buy from Medicine Direct. Depending on your unique experience with the menopause, one treatment may be more suitable for you than another. One of our doctors will be able to advise.We also stock HRT medicines like:

  • Kilovance
  • Premique
  • Elleste
  • Zumenon

Browse our full selection of treatments on the Hormone Replacement Therapy product page.

Estriol Cream Dosage and Directions

Our pharmacists and prescribers follow NICE guidelines when prescribing Estriol Cream.

Always use Estriol cream exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly before you apply it. Speak to your doctor or pharmacist before using the cream if you are not sure how to apply it.

Cleaning the applicator

It is very important that you keep your applicator clean to ensure hygiene and prevent infections.

To clean your applicator, remove the plunger from the barrel and wash them both in hot soapy water. Do not use boiling water or any detergents to clean them.

Rinse both afterwards, thoroughly, with clean water.

What if I forget to use it?

If you forget to apply Estriol cream, apply it as soon as you remember, as long as you remember within 12 hours.

If it is closer to the time when you should apply your next scheduled dose, just skip the application you missed and continue to apply Estriol as normal the next day.

Never apply two doses in an attempt to make up for a missed one; this will not work and may increase your risk of adverse reactions.

What if I use too much?

Do not use this medicine more than once a day.

Over-applying this medicine may result in certain side effects.

If you are bothered by any adverse reactions, or become worried, you should speak to your doctor as soon as possible.

Where is Estriol applied?


This cream comes with an applicator that should be inserted into the vagina to apply the cream.

Can Estriol be applied to the face?


When applied to the face, Estriol can help to treat wrinkles and fine lines. However, this is not why it is prescribed and should not be used as an anti-ageing treatment. Using too much oestrogen therapy can result in side effects.

Can you gain weight from Estriol?


Some women claim that using an HRT treatment like Estriol cream makes them gain weight. However, this has never been proven to be connected to using HRT. The menopause can cause weight gain anyway, but you can avoid this by eating a balanced diet and getting enough exercise.

What is the best time of day to use Estriol?


Ideally, you should apply this cream at night. This will give it time to absorb and get to work. You should apply Estriol when lying down, so doing it at bedtime also makes it more convenient for you.

What should I do if I’ve used too much?


Never exceed the stated dose. If you apply too much cream, wash it out straight away. You can suffer side effects from using too much of an oestrogen therapy.

How long should you use HRT?


You will normally be told to take HRT for less than five years. You should discuss the potential dangers and benefits with your doctor if you wish to take it for longer than this.

How can you tell if you have low oestrogen levels?


You may have low oestrogen levels if you experience hot flashes, pain during sex, vaginal dryness or missed periods. Speak to your doctor if you keep getting any of these symptoms.

How old is too old for HRT?


Women over the age of 60 are not normally prescribed HRT, although this is not always the case. Talk to your doctor about whether HRT would be beneficial to you.

Does Estriol cause hair loss?


Hair loss can occur during menopause due to declining levels of oestrogen and progesterone. HRT often helps to reverse this by increasing the levels of these hormones in the body.

Can Estriol make your bones healthier?


Research has suggested that Estriol may help to fight against degenerative osteoporosis.

Side Effects

Rarer side effects associated with Estriol cream include:

  • Yellowing of the skin or around the eyes
  • Headaches or dizziness
  • Difficulty in swallowing
  • Blood clots, a heart attack or a stroke
  • Disturbed vision
  • Increased in your blood pressure
  • Worsening of liver problems
  • New or unusual migraines, with or without disturbed vision

You should stop using the treatment and speak to your doctor as soon as possible if you experience any of the above symptoms.

Serious allergic reactions

In rarer cases, you could suffer a serious allergic reaction to Estriol and require immediate treatment in hospital.

You should either call 999 or go to A&E straight away if you experience any of the following symptoms:

  • You are wheezing
  • You are finding it difficult to speak or breathe
  • You have swelling in the face, throat, lips, mouth or tongue
  • You get a skin rash that is red, itchy, blistered, swollen or peeling skin

You have tightness in your chest or throat

Always read the patient information leaflet before taking any medication.

Warnings and drug interactions

As is the case with all medicines, Estriol cream may interact with other drugs, which can hinder its effectiveness and also increase your risk of side effects.

For more information on medicines that interact with Estriol.

Stroke risks

The risk of having a stroke is increased when using an HRT treatment, due to your chances of developing a blood clot being raised.

This is made even more likely if you:

  • Are a smoker
  • Are getting older
  • Have high blood pressure
  • Drink large amounts of alcohol on a regular basis
  • Have an irregular heartbeat

Blood clotting risks

HRT may increase your risk of blood clotting in your veins by up to 3 times, particularly during your first year of using it.

Not all blood clots are serious, but if they travel to the lungs, it can cause chest pain, breathlessness, collapse and death.

This risk increases as you age, but is made even more likely if:

  • You are very overweight
  • You have had a blood clot before
  • Any of your close family have had blood clots
  • You are pregnant or have recently given birth
  • You have had one or more miscarriages
  • You have any blood clotting problems which require treatment with a medicine like warfarin
  • You are off your feet for a long time because of major surgery, injury or illness
  • You have a rare illness called SLE
  • You have cancer

Speak to your doctor for advice before taking an HRT treatment if any of the above conditions apply to you.

Breast cancer

Women who have suffered from breast cancer, currently have it, or are suspected of having it, should not take HRT unless advised by a doctor, as this can increase your risk of cancer.

Ovarian cancer

Studies have suggested that oestrogen-only HRT, when taken for longer than 5 years, may slightly increase your risk of developing ovarian cancer by 1 extra case per 2,500 women.

Endometrial cancer

Oestrogen-only HRT, when taken for extended periods, can increase your risk of endometrial cancer (cancer of the lining of the womb).

Pregnancy and breastfeeding

Before using this medication, you should make sure you inform your doctor if you are currently pregnant, think that you may be pregnant, or are trying to get pregnant.

You should also tell your doctor if you are currently breastfeeding.

Estriol Cream Ingredients

The main active ingredient within this medicine is: Estriol

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Reviewed bySonia Khan MPharm: 2076091

Updated on: 02/09/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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