Estriol Cream

  • Helps to treat the vaginal symptoms of menopause
  • Cream must be applied daily for full benefits
  • Comes with applicator for ease of use
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From As low as £49.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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What is Estriol Cream?

Estriol cream is a hormone replacement therapy (HRT), prescribed to treat the symptoms of menopause.

You can buy Estriol cream from Medicine Direct following an online consultation with one of our certified doctors.

If you order before 2pm, we can offer you next day delivery on your medicine, which will arrive in discreet packaging.

What is Estriol Cream used to treat?

Women who use Estriol cream do so to relieve the vaginal symptoms of the menopause.

When a woman goes through the menopause, the levels of oestrogen in her body will drop significantly. This may lead to problems like vaginal dryness, inflammation and pain when you have sex.

A hormone replacement therapy cream like Estriol helps to combat this.

Estriol is the active ingredient in the medicine, which is a weak oestrogen and a minor female sex hormone, meaning it helps to alleviate many of the symptoms of menopause and allows you to lead a normal life.

Dosage

Always use Estriol cream exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly before you apply it. Speak to your doctor or pharmacist before using the cream if you are not sure how to apply it.

The recommended dosage of Estriol cream is 0.01%, which is the dose we sell at Medicine Direct. You should apply 5ml of the cream to your vagina each time.

Apply this treatment once a day, ideally in the evening.

Estriol cream is for external use only. Do not ingest this cream; if you or anyone else accidentally swallows the cream, you should seek medical attention as soon as possible.

Avoid getting this cream in your eyes, nostrils or mouth.

How to apply Estriol cream

Below is a step-by-step list of instructions as to how you should use this medication:

  • Wash your hands thoroughly
  • Use the top of the cream's cap to pierce the metal film seal at the top of the tube
  • Make sure the plunger is properly inserted into the applicator
  • Screw the end of the applicator to the top of the tube
  • Squeeze the tube to fill the applicator
  • Remove the applicator and replace the cap on the tube
  • Lie down and bend your knees upwards, keeping your legs spread apart
  • To apply the cream, insert the applicator high into your vagina and firmly push the plunger down
  • Remove the applicator once this is complete and wash your hands again

Cleaning the applicator

It is very important that you keep your applicator clean to ensure hygiene and prevent infections.

To clean your applicator, remove the plunger from the barrel and wash them both in hot soapy water. Do not use boiling water or any detergents to clean them.

Rinse both afterwards, thoroughly, with clean water.

What if I forget to use it?

If you forget to apply Estriol cream, apply it as soon as you remember, as long as you remember within 12 hours.

If it is closer to the time when you should apply your next scheduled dose, just skip the application you missed and continue to apply Estriol as normal the next day.

Never apply two doses in an attempt to make up for a missed one; this will not work and may increase your risk of adverse reactions.

What if I use too much?

Do not use this medicine more than once a day.

Over-applying this medicine may result in certain side effects.

If you are bothered by any adverse reactions, or become worried, you should speak to your doctor as soon as possible.

Who can use Estriol Cream?

Estriol cream is not suitable for everyone to use.

Speak to your doctor before using this medication if any of the below conditions apply to you:

  • You have high blood pressure
  • You have had a heart attack
  • You have fibroids
  • You have liver disease or any other liver problems
  • You suffer from migraines
  • You have diabetes
  • You have any gallbladder problems
  • You have epilepsy
  • You suffer from systemic lupus erythematosus
  • You have asthma
  • You have otosclerosis
  • You have angioedema
  • You have mastopathy
  • You have endometriosis or any other womb problems
  • You have any blood clot problems or are prone to a blood clot
  • You have porphyria
  • You have, think you may have, or have ever had, breast cancer

Possible side effects

As with any medication, Estriol cream comes with the risk of certain side effects, although not all women who uses it will suffer from them.

Speak to your doctor if any of these reactions bother you or do not go away:

  • Vaginal discharge
  • Breakthrough bleeding
  • Breast pain or tenderness
  • Feeling sick or being sick
  • Pre-menstrual tension syndrome (PMT)
  • Needing to urinate more often or pain when you urinate
  • Feeling bloated, stomach cramps or stomach pain
  • Patches or darkened skin, painful swelling or bruising in the legs, or small red marks on the skin
  • Faster or irregular heartbeats
  • Leg pain
  • Depression
  • Dementia (memory loss) over the age of 65

This list is not exhaustive. Please, refer to the Side Effects tab on this page for rarer, more serious reactions you may suffer.

Always read the patient information leaflet thoroughly before using a new medication.

How to order Estriol Cream safelt online

You should never order any form of medication online unless it is from a UK registered pharmacy, which is registered with the General Pharmaceutical Council (GPC), like Medicine Direct.

Ordering your medicine online with us will ensure that you are only purchasing genuine forms of the medication you need. Your order will be despatched in discreet packaging and we can offer you next day delivery if you place your order before 2pm the day before.

Furthermore, all of our doctors are certified and fully registered, meaning they can offer impartial, professional advice and legally prescribe medication they deem appropriate to treat your condition(s). Our doctors are also registered with the General Medical Council (GMC).

Estriol Cream Dosage and Directions

Our pharmacists and prescribers follow NICE guidelines when prescribing Estriol Cream.

Always use Estriol cream exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly before you apply it. Speak to your doctor or pharmacist before using the cream if you are not sure how to apply it.

The recommended dosage of Estriol cream is 0.01%, which is the dose we sell at Medicine Direct. You should apply 5ml of the cream to your vagina each time.

Apply this treatment once a day, ideally in the evening.

Estriol cream is for external use only. Do not ingest this cream; if you or anyone else accidentally swallows the cream, you should seek medical attention as soon as possible.

Avoid getting this cream in your eyes, nostrils or mouth.

How to apply Estriol cream

Below is a step-by-step list of instructions as to how you should use this medication:

  • Wash your hands thoroughly
  • Use the top of the cream's cap to pierce the metal film seal at the top of the tube
  • Make sure the plunger is properly inserted into the applicator
  • Screw the end of the applicator to the top of the tube
  • Squeeze the tube to fill the applicator
  • Remove the applicator and replace the cap on the tube
  • Lie down and bend your knees upwards, keeping your legs spread apart
  • To apply the cream, insert the applicator high into your vagina and firmly push the plunger down
  • Remove the applicator once this is complete and wash your hands again

Cleaning the applicator

It is very important that you keep your applicator clean to ensure hygiene and prevent infections.

To clean your applicator, remove the plunger from the barrel and wash them both in hot soapy water. Do not use boiling water or any detergents to clean them.

Rinse both afterwards, thoroughly, with clean water.

What if I forget to use it?

If you forget to apply Estriol cream, apply it as soon as you remember, as long as you remember within 12 hours.

If it is closer to the time when you should apply your next scheduled dose, just skip the application you missed and continue to apply Estriol as normal the next day.

Never apply two doses in an attempt to make up for a missed one; this will not work and may increase your risk of adverse reactions.

What if I use too much?

Do not use this medicine more than once a day.

Over-applying this medicine may result in certain side effects.

If you are bothered by any adverse reactions, or become worried, you should speak to your doctor as soon as possible.

Estriol Cream FAQ's

What is Estriol cream?


It is a hormone replacement therapy used to treat the symptoms associated with the menopause. Estroil is a mild oestrogen and minor female sex hormone, which helps to alleviate symptoms like vaginal dryness and inflammation. Having sex can become painful due to dryness when you are going through the menopause, so Estriol cream can help to make your sex life more enjoyable by alleviating the dryness.

How does it work?


Estriol is a mild oestrogen, meaning this cream helps to boost your oestrogen levels when you are going through the menopause. Women who are experiencing menopause will suffer a decrease in the levels of oestrogen in their bodies, which can lead to a range of symptoms, such as vaginal dryness, inflammation and pain when you have sex. By applying this cream daily, you are able to alleviate these symptoms, helping you to resume normal sexual activity and go about your daily life without pain or discomfort.

How do you use Estriol cream?


Always apply Estriol exactly as instructed by your doctor or pharmacist. If you have any questions about how to apply it, speak to them for guidance. Comprehensive information can be found in the patient information leaflet, which will accompany your medication when you order it from Medicine Direct.

You should apply this treatment as follows:

  • Wash your hands thoroughly
  • Use the top of the cream's cap to pierce the metal film seal at the top of the tube
  • Make sure the plunger is properly inserted into the applicator
  • Screw the end of the applicator to the top of the tube
  • Squeeze the tube to fill the applicator
  • Remove the applicator and replace the cap on the tube
  • Lie down and bend your knees upwards, keeping your legs spread apart
  • To apply the cream, insert the applicator high into your vagina and firmly push the plunger down
  • Remove the applicator once this is complete and wash your hands again
  • Avoid contact with the eyes, mouth and nostrils. This cream is for external use only; if you or anyone else swallows Estriol, you should call 111 for advice straight away. If you miss a dose, apply it as soon as you remember as long as it is within 12 hours of the time you should have applied Estriol. If it is closer to your next dose, then skip the missed dose and continue using with the next day dose.

    How do I buy Estriol cream online?


    Estroil cream is available to purchase online from Medicine Direct. We sell the cream in an 80g tube, which will provide treatment for 160 days, in the dosage of estriol 0.01%. After an online consultation with one of our certified doctors, they will prescribe you Estriol if they deem it an appropriate medication for you. If you order with us before 2pm, you can benefit from next day delivery. Never order medicine online unless it is from a pharmacy that is registered with the General Pharmaceutical Council (GPC) and the General Medical Council (GMC), like Medicine Direct.

    Who can use Estriol cream?


    This medication is not suitable for everyone to use, particularly if you have pre-existing conditions, such as high blood pressure or blood clotting. A list of conditions that may affect your suitability for using Estriol cream can be found on the main product page. A comprehensive list will be found in the patient information leaflet, which will come with your medicine.

    Is Estriol the best treatment for me?


    Speak to a doctor before you begin to apply this cream, to make sure that it is a suitable treatment for you. At Medicine Direct, you will have an online consultation with a certified doctor, who will assess your individual case and determine whether Estriol is appropriate for you. From there, you can order it online and if you order before 2pm, we can offer you next day delivery.

    Are there any alternative HRT treatments?


    Yes, hormone replacement therapy treatments come in various different forms, such as patches and tablets. Depending on your symptoms, you may benefit from a different form of treatment. You should speak to your doctor about all the options available to you; this will help you to make a decision.

    When should I get emergency help?


    If you suffer a serious allergic reaction, you should call 999 or go to A&E immediately, as you could require urgent treatment in hospital. You may be experiencing a serious allergic reaction if: You are wheezing, You are finding it difficult to speak or breathe, You have swelling in the face, throat, lips, mouth or tongue, You get a skin rash that is red, itchy, blistered, swollen or peeling skin, You have tightness in your chest or throat. If you experience any adverse reactions, a list of which can be found in the patient information leaflet, you should speak to your doctor as soon as possible. If you have any concerns, you should not hesitate to seek medical attention.

    Side Effects

    Rarer side effects associated with Estriol cream include:

    • Yellowing of the skin or around the eyes
    • Headaches or dizziness
    • Difficulty in swallowing
    • Blood clots, a heart attack or a stroke
    • Disturbed vision
    • Increased in your blood pressure
    • Worsening of liver problems
    • New or unusual migraines, with or without disturbed vision

    You should stop using the treatment and speak to your doctor as soon as possible if you experience any of the above symptoms.

    Serious allergic reactions

    In rarer cases, you could suffer a serious allergic reaction to Estriol and require immediate treatment in hospital.

    You should either call 999 or go to A&E straight away if you experience any of the following symptoms:

    • You are wheezing
    • You are finding it difficult to speak or breathe
    • You have swelling in the face, throat, lips, mouth or tongue
    • You get a skin rash that is red, itchy, blistered, swollen or peeling skin

    You have tightness in your chest or throat

    Always read the patient information leaflet before taking any medication.

    Warnings and drug interactions

    As is the case with all medicines, Estriol cream may interact with other drugs, which can hinder its effectiveness and also increase your risk of side effects.

    You must always make sure that your doctor or pharmacist is aware if you are already taking any other medicines, before you start to use a new treatment. This includes both prescription and non-prescription medications, herbal remedies, vitamins and supplements.

    In particular, you should ensure you inform your doctor if you are currently using any of the following medicines:

    • Any medicine that contains St John's Wort, normally used to treat depression
    • Any medicines which are used to treat epilepsy, such as phenobarbital, phenytoin or carbamazepine
    • Any medicines used to treat infections, such as s rifampicin, rifabutin, nevirapine or efavirenz
    • Medications used to treat the HIV infection, including ritonavir and nelfinavir
    • Bosentan, to treat high blood pressure in the lungs' blood vessels

    For more information on medicines that interact with Estriol.

    Stroke risks

    The risk of having a stroke is increased when using an HRT treatment, due to your chances of developing a blood clot being raised.

    This is made even more likely if you:

    • Are a smoker
    • Are getting older
    • Have high blood pressure
    • Drink large amounts of alcohol on a regular basis
    • Have an irregular heartbeat

    Blood clotting risks

    HRT may increase your risk of blood clotting in your veins by up to 3 times, particularly during your first year of using it.

    Not all blood clots are serious, but if they travel to the lungs, it can cause chest pain, breathlessness, collapse and death.

    This risk increases as you age, but is made even more likely if:

    • You are very overweight
    • You have had a blood clot before
    • Any of your close family have had blood clots
    • You are pregnant or have recently given birth
    • You have had one or more miscarriages
    • You have any blood clotting problems which require treatment with a medicine like warfarin
    • You are off your feet for a long time because of major surgery, injury or illness
    • You have a rare illness called SLE
    • You have cancer

    Speak to your doctor for advice before taking an HRT treatment if any of the above conditions apply to you.

    Breast cancer

    Women who have suffered from breast cancer, currently have it, or are suspected of having it, should not take HRT unless advised by a doctor, as this can increase your risk of cancer.

    Ovarian cancer

    Studies have suggested that oestrogen-only HRT, when taken for longer than 5 years, may slightly increase your risk of developing ovarian cancer by 1 extra case per 2,500 women.

    Endometrial cancer

    Oestrogen-only HRT, when taken for extended periods, can increase your risk of endometrial cancer (cancer of the lining of the womb).

    Pregnancy and breastfeeding

    Before using this medication, you should make sure you inform your doctor if you are currently pregnant, think that you may be pregnant, or are trying to get pregnant.

    You should also tell your doctor if you are currently breastfeeding.

    Ingredients

    The active ingredient contained in this cream is estriol 0.01%.

    Please, refer to the patient information leaflet for a list of inactive ingredients.

    Delivery Company Delivery Service Price Details
    Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
    DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
    DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
    DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

    Delivery specified for Saturday

    Order Friday by 2pm (subject to Dr approval)

    Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

    Written bySonia Khan MPharm: 2076091

    Updated on: 03/06/2021

    This content has been written by our Pharmacist Sonia Khan and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh

    Sonia Khan
    MPharm: 2076091

    Pharmacist

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