• Used to treat post-menopausal women
  • Take one tablet daily
  • Modified release tablets
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What is Premique?

Premique is a combined form of hormone replacement therapy (HRT). It is prescribed for women who are going through the menopause. The two active ingredients in Premique are medroxyprogesterone acetate and conjugated oestrogens, which mimic the female sex hormones oestrogen and progesterone.

You can buy Premique from Medicine Direct following an online consultation with a registered doctor. If you order online by 2pm, we are able to offer you free next day delivery. We sell Premique as a 0.3mg dosage in packets of 84 tablets.

What is Premique used to treat?

Premique is a hormone replacement therapy (HRT) designed to help ease the symptoms of the menopause. All women will go through the menopause, usually between the ages of 45 and 55. During this time, your ovaries will produce less and less oestrogen, which stops your menstrual cycle.

While the menopause is a natural part of a woman's ageing process, it can have a large impact on your daily life, manifesting itself in various physical symptoms.

Symptoms of the menopause include:

  • Night sweats
  • Hot flushes
  • Vaginal dryness
  • Dryness of the eyes
  • Osteoporosis
  • Insomnia
  • Depression
  • Irritability

Symptoms generally last for around four years, although they will begin several years before you start the menopause.

What are the benefits of taking Premique?

A treatment like Premique eases the symptoms of the menopause by supplementing the hormones that your body no longer naturally produces. Some HRT treatments are oestrogen-only, but this can lead to complications in women who still have a uterus. Premique also contains medroxyprogesterone acetate, which means you will not have monthly bleeding, but the medication will balance the effects of added oestrogen in your system.

Premique, like all HRT medicines, will not prevent women who are still fertile from becoming pregnant. If you are under the age of 50, you are still considered to be fertile until two years after your final menstrual cycle.

Who can take Premique?

You should not take Premique if any of the following applies to you:

  • You are allergic to medroxyprogesterone acetate, conjugated oestrogens or any other ingredients contained in this medicine
  • You have any unexplained vaginal bleeding
  • You have or have ever had a blood clot in a vein or the lungs
  • You have ever had breast cancer, or you are suspected of having it
  • You have or are suspected of having cancer that is oestrogen-sensitive, such as cancer of the womb lining
  • You have any blood clotting disorders
  • You have excessive thickening of the womb lining that has not been treated
  • You have the inherited blood problem, porphyria
  • You have or have recently had a disease that was caused by blood clots in the arteries, including a heart attack, stroke or angina
  • You have or have ever had a liver disease and your liver function tests have not gone back to normal

Possible side effects

As with all medication, Premique does come with certain side effects, although not everyone who takes it will experience them.

Common adverse effects may include:

  • Breast pain
  • Depression
  • Increase or decrease in weight
  • Muscle and joint pain
  • Breast tenderness or swelling
  • Nipple discharge
  • Changes in your triglyceride levels

Less common reactions can include:

  • Vaginal thrush
  • Headaches or migraine
  • Nausea, bloating or abdominal pain
  • Mood changes
  • Changes in vaginal discharge or menstrual flow
  • Changes in your sex drive
  • Facial or ankle swelling
  • Dizziness
  • Blood clots in your veins
  • Itchiness
  • Acne
  • Gallbladder disease
  • Hair loss
  • Difficulty wearing contact lenses

Speak to your doctor if any of these reactions bother you or do not go away.

Please note, these lists are not exhaustive. Refer to the Side Effects tab for a list of the rarer and more serious reactions you may suffer. Always read the patient information leaflet for a comprehensive list of unwanted effects.

Premique Dosage

Our pharmacists and prescribers follow NICE guidelines when prescribing Premique.

Always take Premique Low Dose exactly as instructed by your doctor. Read the patient information leaflet thoroughly before taking it; speak to your doctor or pharmacist if you are unsure of anything.

Premique tablets should be swallowed whole with a drink of water. Do not crush, chew or cut them in half.

The recommended dose is one tablet each day, try to take the tablet at the same time every day. Your doctor will always prescribe you the lowest dose possible, and you should speak to them if you think the medication dose is too high or not high enough.

If you are not taking any other HRT, or you are taking another period-free HRT, you can start taking Premique Low Dose at any time. If you are changing from an HRT that gives you a period, start taking Premique Low Dose the day after you finish the previous course of medicine, unless your doctor tells you to do otherwise.

Premique Low Dose tablets are marked by days of the week; begin your pack by taking the first tablet that is marked for the right day. Keep taking the treatment until you have taken all 28 tablets. You should not skip any days and you should start your next pack after finishing the last one.

You may have bleeding or spotting as your body gets used to Premique. This should pass in time.

What if I take more than I am supposed to?

An extra dose of Premique is unlikely to harm you, although you may experience:

  • Fatigue
  • Vaginal bleeding
  • Abdominal pain
  • Dizziness
  • Drowsiness
  • Breast tenderness
  • Nausea

These symptoms are unlikely to cause you any harm, but you should speak to your doctor or pharmacist if you become worried.

What if I forget to take it?

If you forget to take a dose, just take it as soon as you remember then continue to take Premique as usual. If you have forgotten to take more than one dose, do not double dose to try and make up for missing several previous ones.

If you have not had a hysterectomy, you may experience light bleeding for a short while if you miss a dose.

To ensure you do not forget to take your tablet, it is best if you try to take it at the same time every day.

If you are going to have an operation

Make sure your doctor is aware if you are going to have surgery. Make sure your surgeon knows you are taking Premique; they may instruct you to stop taking it about 4 to 6 weeks before you have the operation to reduce your risk of blood clotting.

Your doctor will advise you on when it is safe to start taking Premique again.

Premique FAQ's

How does Premique Low Dose work?

This medication is a hormone replacement therapy, which works to help relieve the symptoms of menopause by supplementing the hormones that your body produces less of when you start to go through the menopause.

What are the ingredients in Premique Low Dose?

The two active ingredients are oestrogen and medroxyprogesterone acetate. Inactive ingredients also contained in this medication can be found on the Ingredients tab on this page.

How do I buy Premique online?

You can purchase this hormone replacement therapy medication from Medicine Direct following an online consultation with one of our registered doctors, who will prescribe it if they deem it a suitable treatment for your symptoms. You can then order it from our online pharmacy; order by 2pm and we can offer you next day delivery, absolutely free.

Never order any form of medicine online unless it is from a pharmacy that is registered with the General Pharmaceutical Council (GPhC), like Medicine Direct. All of our doctors are also registered with the General Medical Council, meaning they are legally qualified to prescribe medicine just like your local GP.

What are the advantages of buying Premique online?

Buying Premique online removes the need of going to your local GP or pharmacist and queuing for your medicine. Simply fill out our online consultation form, which will be reviewed by a doctor who will prescribe you the correct medication. You can then order this medicine from our online pharmacy and, if you have ordered by 2pm, you will receive it the very next day. Ordering online from Medicine Direct is as safe as it is easy. We are registered with the General Pharmaceutical Council, which means we can guarantee genuine versions of all medicine we sell.

What are the main symptoms of the menopause?

The main symptoms of the menopause include:
  • Night sweats
  • Hot flushes
  • Vaginal dryness
  • Dryness of the eyes
  • Osteoporosis
  • Insomnia
  • Depression
  • Irritability and other mood changes
  • What happens if I miss a tablet?

    If you miss a tablet, just take it as soon as you remember, then continue taking it as normal. If you miss more than one dose, do not take more than one tablet to make up for it.

    Premique Side Effects

    The more common side effects of Premique can be found on the main page.

    Rarer side effects may include:

    • Changes in breast tissue or milky secretion from breasts
    • Vomiting
    • Ovarian cancer
    • Increased fibroids size
    • Asthma worsening
    • Glucose intolerance
    • Irritability
    • Heart attack
    • Stroke
    • Inflammation of the veins
    • Inflamed pancreas
    • Epilepsy becomes worse

    Very rare side effects may include:

    • Increase in blood pressure
    • Benign liver tumours
    • Blurred vision or loss of vision
    • Worsening of chorea
    • Jaundice
    • Worsening of hypocalcaemia

    Always read the patient information leaflet for the full list of side effects.

    These symptoms should only be temporary and improve over time. If they get worse or do not improve, you should seek medical attention.

    Severe allergic reaction

    In rare cases, you may suffer a serious allergic reaction to Premique and require immediate treatment in hospital.

    You should either call 999 or go to A&E straight away if:

    • You get a skin rash that is red, itchy, swollen, blistered or peeling skin
    • You are wheezing
    • You are finding it difficult to breathe or speak
    • You have swelling in your face, throat, lips, tongue or mouth

    You have tightness in the chest or throat

    Premique Warnings and drug interactions

    Premique may interact with other medications, which may lead to irregular bleeding.

    Before taking a new medication, it is very important that you inform your doctor of any medicine you are already taking. This includes both prescription and non-prescription medicine, vitamins, supplements and herbal remedies.

    In particular, make sure your doctor and pharmacist are aware if you are currently taking any of the following:

    • Medicines to treat the HIV infection
    • Medicines for epilepsy
    • Medicines for tuberculosis
    • Aminoglutethimide
    • Metyrapone
    • Herbal remedies which contain St. John's wort

    Tell your doctor before taking Premique if you have or have ever had any of the following conditions:

    • Diabetes
    • Migraines
    • Fibroids
    • Impaired liver function
    • Family history of breast cancer or any oestrogen-sensitive cancers
    • Heart disease
    • You are at a high risk of blood clots
    • You have low calcium levels in the blood
    • High blood pressure
    • Epilepsy
    • Asthma
    • Uterine problems
    • High levels of fat in the blood
    • Fluid retention
    • Systemic lupus erythematosus
    • Otosclerosis

    Find out more on medicines that interact with Premique

    HRT can increase your risk of breast cancer when taken for extended periods. How high the risk is depends on how long your hormone replacement therapy lasts and whether you are taking combined or oestrogen-only HRT. It is important that you regularly check your breasts for lumps or changes in the skin or nipple. Women may also have an increased risk of ovarian cancer if they use Hormone Replacement Therapy for longer than five years.

    Stop using this treatment and seek urgent medical attention if you have any symptoms of the following:

    • Stroke (sudden migraines and/or blurred vision)
    • Liver disease (yellowing of the skin or the whites of the eyes)
    • Heart disease (chest pain that travels to the neck or arm)
    • Blood clots (pain and swelling in your legs, trouble breathing)

    Always read the patient information leaflet for a full list of warnings for this treatment. If you have any questions or doubts at all, we strongly advise you to speak to your doctor before you start taking it.

    Pregnancy and breastfeeding

    This medication is for women who are post-menopausal only. Therefore, you should not use it if you are pregnant or breastfeeding.

    Make sure your doctor is aware if you are currently pregnant, are trying to get pregnant, or think you might be pregnant.

    Premique Ingredients

    The two active ingredients in Premique are oestrogen and medroxyprogesterone acetate.

    The inactive ingredients are: lactose monohydrate, sucrose, calcium phosphate tribasic, calcium sulfate anhydrous, microcrystalline cellulose, carnauba wax, glyceryl monooleate, magnesium stearate, methylcellulose, macrogol, pharmaceutical glaze, povidone, titanium dioxide (E171), stearic acid and colour (E132, indigo carmine), iron oxide black (E172) shellac, n-Butyl alcohol, propylene glycol, ethyl acetate.

    Delivery Company Delivery Service Price Details
    Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
    DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
    DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
    DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

    Delivery specified for Saturday

    Order Friday by 2pm (subject to Dr approval)

    Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

    Written bySonia Khan MPharm: 2076091

    Updated on: 03/06/2021

    This content has been written by our Pharmacist Sonia Khan and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh

    Sonia Khan
    MPharm: 2076091


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