Elleste Solo

  • Relieves menopause symptoms
  • Replenishes the body with Oestrogen lost due to the menopause
  • Helps to prevent Oseoporosis
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From As low as £19.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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What is Elleste Solo?

Elleste Solo is a hormone replacement therapy (HRT) that is prescribed to ease the symptoms of the menopause in women. Additionally, it can be prescribed as a preventative treatment against osteoporosis.

These tablets contain estradiol, which is a synthetic version of the female hormone oestrogen.

You can only buy Elleste Solo if it has been prescribed for you by a doctor.

What is Elleste Solo used to treat?

Elleste Solo is used to relieve a range of symptoms associated with the menopause, which most commonly starts when a woman is between the ages of 45 and 55.

When a woman goes through the menopause, her body's oestrogen levels begin to drop, which can cause various symptoms including hot flushes, night sweats and vaginal dryness.

Although the menopause is a completely natural part of a woman’s ageing process, these symptoms can be very debilitating. HRT medicines like Elleste Solo provide effective relief from them and allow women to lead a normal life.

Some women can develop osteoporosis after the menopause, which is where your bones become fragile. Elleste Solo is sometimes prescribed to prevent this from occurring.

How does Elleste Solo work?

Elleste Solo works by supplementing the levels of oestrogen that your body loses due to the menopause. Estradiol is a synthetic version of oestrogen and works to top up your body’s oestrogen levels, which relieves the symptoms of the menopause.

You should start to notice an improvement in your symptoms after a few weeks of taking this medicine.

If you still have an intact uterus, you will also need to take a progestogen medication alongside Elleste Solo. When your oestrogen levels are increased on their own, this can cause excessive growth of the womb lining, which can lead to health risks like endometrial cancer.

How to take Elleste Solo

Take Elleste Solo as instructed by your doctor. Read the patient information leaflet for complete instructions on how this medication should be taken.

If you still have regular periods, you should start taking Elleste Solo on the first day you have a bleed. If you are no longer having periods, you can begin taking it immediately.

If you are changing over from taking a different form of HRT, you should finish the current course of medicine you are on before you start taking Elleste Solo, unless your doctor tells you otherwise. Follow your doctor’s instructions and ask them what to do if you are not sure.

  • Take one tablet at the same time each day. You can take Elleste Solo at the most convenient time of day for you.
  • Swallow Elleste Solo tablets whole with a drink of water. Do not crush or chew them.
  • All the tablets contained in the pack are the same dosage, but you should follow the arrows on the pack, which are marked with a day of the week to help you to keep track.
  • Do not leave a gap between packs. When you finish one strip, start the next one the day after.

Who can take Elleste Solo?

Using Hormone Replacement Therapy treatments like Elleste Solo comes with certain risks, which should be discussed before you start to take it.

Your doctor will speak to you about your family's medical history before they prescribe you this medicine.

Do not take this medicine if:

  • You have ever had or are suspected of having breast cancer
  • You have any unexplained vaginal bleeding
  • You have any kind of cancer which is sensitive to oestrogens, such as cancer of the womb lining, or you are suspected of having it
  • You have ever had a blood clot in a vein, such as in your legs, or in the lungs
  • You have a blood clotting disorder
  • You have ever had a disease that was caused by blood clots in the arteries, including a stroke, heart attack or angina
  • You have ever had liver disease
  • You suffer from porphyria
  • You have an allergy to estradiol hemihydrate, or any of the other ingredients contained in this medication

This list is not exhaustive. Read the patient information leaflet for full reasons why Elleste Solo may be unsuitable for you to take.

Can you buy Elleste Solo over the counter?

No, Elleste Solo is not available to purchase over the counter. This medicine is only available on prescription.

Can you buy Elleste Solo online in the UK?

Yes, you can buy Elleste Solo online from most regulated pharmacies, like Medicine Direct. However, as this is a prescription-only medicine (POM), you must first have an online consultation with a registered doctor, pharmacist or prescriber before you can order it.

Elleste Solo alternatives

Hormone replacement therapy is available as a large variety of medicines to suit different women’s unique circumstances. This means that HRT can provide relief for a wide range of menopausal women.

Aside from Elleste Solo, Medicine Direct also stocks a selection of other renowned HRT medications, including:

  • Zumenon also contains the active ingredient Estradiol
  • Femoston
  • Premique
  • Elleste Duet

Elleste Duet is a combined version of HRT, meaning it also contains a progestogen medicine alongside oestrogen.

Elleste Solo Dosage

Our pharmacists and prescribers follow NICE guidelines when prescribing Elleste Solo.

Always take Elleste Solo exactly as instructed by your doctor. Read the patient information leaflet thoroughly before you start to take it. Speak to your doctor or pharmacist if you are not sure of how to take it.

Your doctor will prescribe you the lowest possible dose, for the shortest period possible. Speak to your doctor if you do not think the dose is strong enough, or if it is too strong.

What if I forget to take it?

If you miss a tablet, take it as soon as you remember, then continue taking Elleste Solo at your normal time.

If you miss a tablet by more than 12 hours, safely dispose of the tablet you forgot to take and just take your next dose at the normal time you take this medicine.

Never double double dose in an attempt to make up for a missed dose.

If you have not had a hysterectomy, you may suffer breakthrough bleeding or spotting.

What if I take more than I'm supposed to?

If you accidentally take too much Elleste Solo, you are unlikely to experience any adverse effects.

However, you may feel sick, dizzy or vomit. You may also feel tired or suffer withdrawal bleeding. This does not require any treatment, but you should contact your doctor if you become worried.

If you are due to have surgery

Make sure your doctor is aware if you are scheduled to have any kind of surgery.

You may be required to stop taking Elleste Solo between 4 and 6 weeks before the surgery, to reduce the risk of blood clotting.

Speak to your doctor about when you will be able to start taking Elleste Solo again.

How long does Elleste Solo take to work?

Like most HRT medicines, it will normally take a few weeks before you start to feel the benefits of Elleste Solo. It can take up to three months before it reaches its full effect.

Can I put on weight while taking HRT?

Weight changes are a possible side effect of Elleste Solo. Weight gain is often reported by women who are taking HRT. However, there is no proven link between taking HRT and weight gain. Often, the menopause causes women to gain weight anyway, whether they use HRT or not; this can be combatted by exercise and eating healthily.

Is it safe to take HRT?

HRT comes with certain risks, such as a slightly increased risk of developing certain conditions like blood clots, certain types of cancer and heart disease. To make sure it is safe for you to take, you should tell your doctor if you have any existing health conditions, or if you are at risk of developing any.

Can I start taking HRT if I’m over 60?

Women over 60 are not usually prescribed HRT, although studies have suggested that women starting this medication over the age of 60 are not at an increased risk of cardiovascular events.

Can I keep taking HRT after my menopause?

Most experts agree that you should not take HRT for longer than five years. However, some people are prescribed Elleste Solo and other medicines after the menopause to prevent osteoporosis. Speak to your doctor if you believe you could benefit from staying on HRT.

Will taking Elleste Solo improve my anxiety?

Taking a HRT treatment like Elleste Solo works to improve mood swings, which are a common symptom of menopause. This can help to reduce anxiety and make you feel happier in general.

Will I be able to sleep better when I’m taking Elleste Solo?

Improved sleep quality is a benefit of HRT. The menopause can often cause insomnia or other sleeping problems, so using Elleste Solo should help to relieve these issues.

Is taking HRT more effective than antidepressants?

Using a HRT medicine like Elleste Solo can help to combat the symptoms of depression in many women, if their depression is triggered by the menopause. However, if you still feel depressed while taking HRT, or if you suffered from depression before your menopause, you should speak to your doctor. Elleste Solo or other HRT treatments should not be used solely for depression.

How will I know if my dose is too high?

If you are experiencing any adverse effects like bloating, breast tenderness, headaches, mood swings or irregular periods, your oestrogen dose may be too high. Do not adjust your dose yourself. Speak to your doctor if you think the dose they have prescribed you is too high or low.

How old will I be when I start to need Elleste Solo?

The age a woman starts her menopause is different for everyone. However, for most women it is between the ages of 45 and 55.

Elleste Solo Side Effects

The more common adverse effects of taking Elleste Solo can be found on the main product page.

It is also possible that you may suffer from rarer adverse reactions while using this HRT medication. You should seek medical attention if you experience any of the below.

Rarer side effects of taking Elleste Solo include:

  • Increase in facial and body hair
  • Intolerance to contact lenses
  • Unusual vaginal discharge
  • Acne
  • Painful periods
  • Pre-menstrual syndrome
  • Muscle cramps

More serious conditions you may develop are:

  • Breast cancer
  • Stroke
  • Worsening of fits
  • Pain or lumps in the breasts
  • Urinary incontinence
  • Discolouration of the skin

Contact your doctor immediately if you exhibit any of the above symptoms.

In rare cases, it is possible to suffer a serious allergic reaction to Elleste Solo.

Either go to A&E or dial 999 straight away if you experience any of these symptoms:

  • You are finding it difficult to speak or breathe
  • You have a skin rash that is red, itchy, swollen, blistered or peeling skin
  • You have tightness in your chest or throat
  • You have swelling in your face, lips, mouth, tongue or throat
  • You are wheezing

You may require immediate treatment in hospital.

The above lists may not be exhaustive; you should always read the patient information leaflet thoroughly for a comprehensive list of adverse effects you may suffer when you use this medicine.

If you have any questions or worries, you are advised to speak to your doctor about them before you start to take Elleste Solo.

Warnings and drug interactions

Elleste Solo may interact with other medicines and increase your risk of side effects, or work less effectively.

It is very important that your doctor is aware if you are already taking any other forms of medicine. This includes both prescription and non-prescription medication, herbal remedies, vitamins and supplements.

In particular, you should be sure to tell your doctor if you are already taking any of the following medicines:

  • Any medicines used to treat epilepsy, such as phenobarbital, phenytoin or carbamazepine
  • Any medicines prescribed to treat HIV, including ritonavir and nelfinavir
  • Any herbal remedies that contain St. John's Wort as an ingredient

Check the patient information leaflet thoroughly for other medicines which may interact with Elleste Solo.

If you have any doubts, concerns about medicines that interact with Elleste Solo or questions at all, we strongly advise you to speak to your doctor about them before you start taking Elleste Solo.

Driving and operating machinery

While Elleste Solo does not directly impair your ability to drive and operate machinery, you should note that possible reactions to this medicine include dizziness and feeling tired.

If you experience these symptoms, you should not drive, ride a bike or operate any machinery until you feel better again.

Pregnancy and breastfeeding

This medication is only prescribed to post-menopausal women. It should not be taken by women who are currently pregnant, trying to get pregnant or think they may be pregnant.

If you become pregnant while taking this medicine, stop taking it and seek your doctor's advice as soon as possible.

You should also not take Elleste Solo if you are currently breastfeeding.


The main active ingredient within this medicine is: Estradiol hemihydrate

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.


medically reviewed by Sonia Khan MPharm: 2076091

Updated on: 03/09/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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