Mebeverine Hydrochloride Tablets (135mg)

  • Relaxes the muscles in and around the gut
  • Eases the pain and cramps caused by IBS
  • Works fast to ease symptoms

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What are Mebeverine 135mg tablets?

Mebeverine is usually taken by adults who are suffering from symptoms of irritable bowel syndrome (IBS).

It contains the active ingredient mebeverine hydrochloride, which is a medication known as an antispasmodic.

Mebeverine comes available as tablets, capsules or a liquid that you swallow.

What is Mebeverine used to treat?

Mebeverine is used to relieve the stomach cramps associated with irritable bowel syndrome (IBS).

IBS is a common condition that affects the digestive system. A poor diet or stress can exacerbate the symptoms of IBS, which include bloating, abdominal pain, stomach cramps, constipation, diarrhoea and flatulence.

Taking Mebeverine will help you to carry on with your day without discomfort and help your body to return to a natural rhythm.

As well as IBS, Mebeverine can also be taken to treat other conditions of the stomach and intestines that cause stomach muscle spasms, including:

  • Spastic colitis
  • Spastic constipation
  • Chronic irritable colon
  • Mucous colitis

How does Mebeverine work to treat IBS symptoms?

Mebeverine hydrochloride is the active ingredient contained in these tablets. This medicine is an antispasmodic that works by relaxing the muscles in your intestine.

IBS pain comes from your intestines going into spasm, causing the muscles to contract very tightly. By relaxing the intestinal muscles, these cramps go away and so does the pain.

Mebeverine will start to work after about an hour of taking it.

Who can take Mebeverine?

Mebeverine can be taken by most adults and children who are at least 10 years old. However, it may not be suitable for everyone.

You should tell your doctor or pharmacist before you use this medication if:

  • You are pregnant, breastfeeding or trying for a baby
  • You are constipated because of paralytic ileus
  • You have had an allergic reaction to Mebeverine or any other medication in the past
  • You have a rare inherited condition that makes it impossible for you to digest galactose (a sugar found in lactose)
  • You are aged 40 years old or over
  • You have blood in your stools
  • You have or think you may have food poisoning (particularly if you have recently been abroad)
  • You are pale or feel tired
  • You have a loss of appetite or have recently lost weight
  • You have unusual vaginal bleeding or vaginal discharge
  • You feel sick or are vomiting

Mebeverine over the counter

You can buy Mebeverine to treat IBS over the counter from pharmacies. It is also available on prescription from your doctor.

Can you buy Mebeverine online in the UK?

To buy Mebeverine online from Medicine Direct, you will first need to complete our online consultation questionnaire. This is to make sure that the medication is suitable for you.

Mebeverine alternatives

There are many alternative IBS medicines available from Medicine Direct.

Fybogel Mebeverine is available to order from our pharmacy. This medicine is contained in an orange-flavoured powder, which you mix with water to make a sweet drink. It works in the same way as Mebeverine and should be taken up to three times a day.

You can also order peppermint oil capsules from our pharmacy, which work to gently relax the muscles in the gut to ease stomach pain. We sell Apercap and Colpermin capsules online.

Buscopan is a tried and tested treatment for stomach cramps, including those brought on by irritable bowel syndrome. Buscopan Cramps is available to order without a prescription from our pharmacy. Alternatively, if you have been diagnosed with IBS, you could opt for Buscopan IBS Relief tablets; both medicines work in the same way.

IBS is a condition that is usually lifelong, there is no cure for IBS, however certain diet changes can help with symptoms.

study into a low-FODMAP diet found that the restriction of FODMAP's (fermentable oligo-, di-, mono-saccharides and polyols, which are essentially short term carbohydrates that are resistant to digestion) was effective at reducing IBS symptoms.

Mebeverine Dosage

The standard dosage for Mebeverine tablets is 135mg. You will normally be instructed by your doctor to take one tablet 3 times a day.

Our pharmacists and prescribers follow NICE prescribing guidelines when prescribing Mebeverine.

Take the tablets 20 minutes before a meal; if you are told to take it twice a day, take it before breakfast and dinner. If you are told to take it 3 times a day, take it before breakfast, lunch and dinner.

You should start to feel the effects of these tablets after about an hour.

Mebeverine tablets should be swallowed whole with a glass of water.

How to take Mebeverine

Take one Mebeverine tablet up to three times a day.

The tablets should be taken around 20 minutes before the three main meals of the day.

Swallow the tablets whole with a glass of water. Do not crush or chew the tablets.

Only take Mebeverine when you are suffering a flare up of symptoms, then stop taking the medicine once they go away. Do not take it continually.

Talk to your doctor if you have been taking this medicine for two weeks and your symptoms have still not gone away.

How does Mebeverine work for IBS?


Mebeverine relaxes the muscles in the intestine, this allows it to relax and stops painful cramps from happening.

How long does it take for Mebeverine to work?


Mebeverine should begin to start working within 1 hour of taking it.

How long should I take Mebeverine for?


Unlike other forms of chronic medicine, Mebeverine does not need to be taken every day. Instead it should be taken when you feel a flare up in symptoms starting. However, it may take up to 2 weeks until your symptoms are relieved.

Is Mebeverine safe to take for a long time?


There are no known long term side effects that are caused by Mebeverine, it is considered safe to use for a long time. However if you are having to use Mebeverine for a long time, this could be a sign of an underlying condition, in which case it is best to see your doctor.

When is the best time to take Mebeverine?


It is recommended to take Mebeverine 20 minutes before each of your meals.

Can I drink alcohol and take Mebeverine?


Yes, there are no harmful interactions between alcohol and mebeverine. However alcohol is a known trigger of IBS so can make your symptoms worse even when taking Mebeverine.

Is Mebeverine a laxative?


No, Mebeverine is not a laxative, it is a antispasmodic medicine that suppresses muscle spasms in the intestine. It will not help you go to the toilet.

Do I need to change my diet when taking Mebeverine?


We recommend knowing what foods trigger your IBS symptoms and cutting them out of your diet to prevent painful symptoms from occurring.

What are the side effects of Mebeverine?

Common side effects when using mebeverine include:

  • Dry mouth
  • Heartburn/Indigestion
  • Skin rash

For more serious side effects, please refer to the "side effects" tab on this page. You can also read the patient information leaflet to familiarise yourself with both common and serious side effects before taking this medicine.

Mebeverine Warnings and drug interactions

It is generally safe to take Mebeverine with other medications, as well as over the counter painkillers like paracetamol and ibuprofen.

You should not take it if you are already using any other medicines to treat IBS symptoms, as these treatments work in the same way. Doing so can make the two medicines interact with each other, which can either render them both ineffective or cause side effects.

However, as with any medicine you have been prescribed, you should always make sure that your doctor is aware of any other medicines you are already taking before you start to use a new one. This includes both prescription and non-prescription medication, herbal remedies, vitamins and supplements.

If you have any doubts or concerns at all, we strongly advise you to discuss them with your doctor before you start using Mebeverine.

Is it safe to use Mebeverine during pregnancy and breastfeeding?

Mebeverine medications are not usually recommended for women who are pregnant as there is not enough research to prove that it is safe for them to take.

If you suffer from IBS and are currently pregnant, think you might be pregnant, or are trying to get pregnant, you should speak to your doctor before you start to take it.

If you are breastfeeding, it should be safe for you to take Mebeverine, but you should still inform your doctor; they will be able to advise you on the best course of treatment for your symptoms.

Read more about taking Mebeverine during pregnancy and breastfeeding.

Mebeverine Ingredients

The main active ingredient within this medicine is: Mebeverine hydrochloride

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

This page has recently been medically reviewed by Sonia Khan MPharm: 2076091

Published on: 12/10/2020

Updated on: 18/08/2021

This content has been written by our Pharmacist Sonia Khan and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh

Sonia Khan
MPharm: 2076091

Pharmacist

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