Trimethoprim 200mg (6 Tablets)

  • Treats Urinary Tract Infections (UTI's) such as Cystitis
  • Clears symptoms in 3 days
  • Relieves painful symptoms of Cystitis

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Trimethoprim 200mg tablets for Cystitis

Cystitis is a type of Urinary Tract Infection (UTI) which is caused by an infection in the bladder. It can cause painful and uncomfortable symptoms such as pain or burning when going to the toilet. For most people cystitis will typically clear within a few days without the need of medication. However, for others, cystitis can come and go more frequently and may need medicine to help with recurring infections.

Trimethoprim 200mg tablets are an effective treatment for Cystitis and can clear the infection within just three days. You can buy Trimethoprim online at Medicine Direct following a consultation with one of our UK prescribers.

What is Trimethoprim?

Trimethoprim is an antibiotic medicine that is used in the treatment of urinary tract infections (UTIs), such as cystitis.

It stops the bacteria that causes UTIs from being able to produce the substances they need to survive. These tablets can be taken by adults and children over the age of 6, although doses differ depending on your age.

You need a prescription to buy Trimethoprim.

What is Trimethoprim used to treat?

Trimethoprim 200mg tablets are used to treat people who are suffering from a urinary tract infection, such as cystitis.

It is highly effective in treating bladder infections and will provide noticeable improvements for the infection after just a few days.

Cystitis is a very common bladder infection and is caused by inflammation of the bladder. You may be suffering from this problem if you have any of these symptoms:

  • Dark, cloudy or strong-smelling urine
  • Pain, stinging or burning when you urinate
  • Feeling sick, tired or unwell
  • Needing to urinate more often
  • Lower abdominal pain

Other conditions Trimethoprim is sometimes prescribed for include acne, travellers’ diarrhoea and middle ear infections.

How does Trimethoprim work?

Trimethoprim is an antibiotic. This medicine works by stopping the bacteria that causes urinary tract infections from producing folic acid, which is a substance they need to be able to survive in your body.

Because the bacteria cannot reproduce and grow, your immune system is able to fight the infection until it is eradicated from your body.

Trimethoprim dose for UTI

The table below demonstrates the average doses of Trimethoprim:

Lower Urinary Tract Infection


Women 200mg twice daily for 3 days
Men 200mg twice daily for 7 days


Always take the dose your doctor prescribes for you. Do not alter the dose without speaking to your doctor first.

How to take Trimethoprim 200mg tablets

Take Trimethoprim tablets at the same time each day.

Swallow the tablets whole with a drink of water. Do not crush or chew them.

Read the patient information leaflet for full instructions.

Take Trimethoprim for as long as your doctor tells you to. Do not stop treatment early, even if you feel better.

Trimethoprim common side effects

Like all medicines, Trimethoprim comes with the risk of side effects, although not everyone who takes this medication will experience them.

Common side effects include:

  • An itching or mild rash
  • Feeling sick
  • Headaches
  • Diarrhoea
  • Hives
  • Thrush
  • Diarrhoea

Please note, this list is not exhaustive. Please refer to the Side Effects tab on this page, for a list of rarer and more serious adverse reactions you may experience while taking this medication.

Who can use Trimethoprim?

Trimethoprim is an antibiotic that provides effective treatment for urinary tract infections, but it may not be suitable for everyone to take.

You should inform your doctor if any of the following apply to you:

  • You have any liver or kidney problems
  • You have any blood disorders, including porphyria
  • You have ever had an allergic reaction to Trimethoprim or any other medicines in the past
  • You have anaemia or low amounts of folic acid (folate) in your blood

This list is not exhaustive. Please make sure you consult the patient information leaflet for a full list of reasons why Trimethoprim may be unsuitable for you to take.

Can you buy Trimethoprim 200mg over the counter?

No, you cannot buy Trimethoprim over the counter. This medicine must be prescribed by a doctor.

Can you buy Trimethoprim online in the UK?

Trimethoprim is available to order online from Medicine Direct. However, as this is a prescription-only medicine (POM), you will first need to complete an online consultation. One of our registered prescribers will assess the answers you provide in a confidential online questionnaire to make sure that Trimethoprim is a suitable medicine for you to take.

Order by 2pm for next day delivery.

Never buy any type of medicine from anywhere other than regulated pharmacies, like Medicine Direct. We are fully regulated by all the necessary regulatory authorities. More information can be found on our About Us page.

Trimethoprim alternatives

Nitrofurantoin is another effective antibiotic for treating UTIs like cystitis. This antibiotic works by killing the bacteria that causes the infection by entering their cells and damaging the genetic material. It is filtered out of the blood and into the urine very quickly, meaning it is able to efficiently and effectively target the root of the problem.

You can order Nitrofurantoin from our online pharmacy after an online consultation.

View the Cystitis page on our website to see our full selection of treatments.

Trimethoprim Indications and Dose

All our Doctors and Pharmacists follow NICE guidelines when prescribing Trimethoprim

Always take Trimethoprim 200mg tablets exactly as instructed by your doctor. Read the patient information leaflet thoroughly before you start using a new treatment. Speak to your doctor or pharmacist if you are unsure of how to take Trimethoprim.

How long will I need to take it for?

How long you will need to take Trimethoprim will depend on your age, where your infection is and how bad it is. It will also depend on your sex and whether you have any existing health problems.

  • Women who have simple UTIs will normally require a course of treatment for 3 days.
  • Men and pregnant women with simple UTIs will normally need to take it for 14 days.
  • Anyone with complicated or severe UTIs, or a catheter, will also need to take it for 14 days.
  • If the UTI causes a man's prostate gland to swell, they may require treatment for 4 to 6 weeks.
  • To prevent UTIs, treatment may last for 6 months, as it may do for treating acne.

Do not stop using this medication until your course is complete, even if you feel better before then.

What if I forget to take it?

If you accidentally miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose.

If it is closer to your next dose than your missed one, skip the dose you missed and continue taking Trimethoprim as usual.

Never double dose in an attempt to make up for missing a previous dose.

To get into the routine of taking this medication, it is best if you take it at the same time every day to avoid forgetting it. Some people find it helps them to set an alarm as a reminder.

What if I take more than I am supposed to?

Accidentally taking an extra dose of Trimethoprim 200 mg is not likely to do you any harm. However, it may increase your risk of temporary side effects, such as diarrhoea, nausea, or vomiting.

If you get severe adverse effects, become worried, or have taken more than one extra dose of this medicine, you should speak to your doctor.

How long until I feel better?

Trimethoprim should have started to make you feel better in just a few days. However, you should not stop taking it until you have completed the course prescribed by your doctor, even if you feel better before then.

What should I do if I don’t get better?

If you do not feel any better after taking it for three days, speak to your doctor. If you start to feel worse at any point during treatment, you should also tell your doctor.

How can I prevent UTIs?

A number of techniques can be applied to lessen the risk of getting a UTI, such as drinking plenty of water, keeping your genitals clean and urinating straight after having sex. The NHS has a list of the dos and don’ts around avoiding UTIs on their website.

Is Trimethoprim a strong antibiotic?

Trimethoprim is a prescription-strength antibiotic that should only be used when prescribed by a doctor. Depending on how old you are and the condition you require it for, the doses can differ.

Can Trimethoprim give me thrush?

Sometimes, thrush can occur while taking antibiotics due to the medicine also killing the protective bacteria that prevents thrush. This can affect both men and women; speak to your doctor if you notice any symptoms of thrush during treatment.

Can I drink alcohol while taking Trimethoprim?

It is safe to drink alcohol while using this medicine.

Should I avoid any food or drink while I’m taking Trimethoprim?

No, you do not need to avoid any types of food or drink and can eat as normal.

Will it affect my contraception?

Trimethoprim has no direct impact on any type of contraception, including the morning after pill. However, if you have diarrhoea or vomit for longer than 24 hours while taking Trimethoprim, your contraception may be affected. If this happens, read the information that comes with your contraception for advice on what to do.

Can you treat UTIs with cranberry juice?

Taking cranberry supplements or drinking cranberry juice is not likely to either treat or prevent a UTI. If you suffer from this issue regularly, you should speak to your doctor.

Will my fertility be affected?

No evidence exists to show that Trimethoprim has any effect on male or female fertility. However, if you are a woman who is trying for a baby, tell your doctor before taking it as Trimethoprim is not normally recommended for pregnant women.

What is trimethoprim used for?

Trimethoprim is an antibiotic used to treat a number of bacterial infections. It is commonly used to treat Urinary Tract Infections (UTI's) such as Cystitis.

Trimethoprim Side Effects

Only 1 in every 1,000 people is likely to experience a serious side effect while taking Trimethoprim.

Speak to your doctor as soon as possible if you suffer any of these rare side effects:

  • Anorexia
  • Depression, anxiety, nightmares, or difficulties in sleeping
  • Involuntary movements
  • Convulsions
  • Feeling dizzy or tired
  • Kidney problems
  • Purple skin discolouration
  • Anaemia
  • Soreness in your mouth or tongue
  • Reduction in the number of blood cells
  • Lupus erythematosus
  • Sore throat
  • Feeling confused or suffering hallucinations
  • Joint or muscle ache
  • Tremors, shaking, or pins and needles
  • Skin becoming sensitive to the sun
  • Low blood sugar

You should call your doctor straight away if you exhibit any of the following symptoms:

  • You have chest pains, an abnormal heartbeat, muscle weakness, or are feeling or being sick – this could be high potassium in your blood
  • You have a serious skin reaction which may include swelling that looks like burns, round red patches, peeling, skin ulcers, or blisters
  • You have unexplained bruising or bleeding, mouth ulcers, a sore throat, a high temperature, tiredness or generally feel unwell – these could be signs of a blood problem
  • You have diarrhoea that contains blood or mucus, or if you have severe diarrhoea that lasts for longer than 4 days

If you have tiredness, a fever, headaches, a stiff neck, you feel ill, or your eyes become very sensitive to light, you should stop taking this medicine and either call 999 or go to A&E straight away. Any of these symptoms could be a sign of meningitis.

Serious allergic reaction

In rare cases, it is also possible that you may suffer a serious allergic reaction to Trimethoprim. You could require immediate treatment in hospital.

You should either call 999 or go to A&E as soon as possible if you exhibit any of the following symptoms:

  • You have swelling in your face, throat, mouth, tongue, or lips
  • You are wheezing
  • You get tightness in your chest or throat
  • You are finding it difficult to speak or breathe
  • You have a skin rash that is red, itching, swollen, blistered or peeling skin

Please note, the above lists may not be exhaustive. Always read the patient information leaflet, which will accompany your medicine, thoroughly, before you start to take it.

If you have any questions or concerns at all, you should not hesitate to discuss them with your doctor.

Trimethoprim Warnings and drug interactions

There are a number of drugs that interact with Trimethoprim.

Before taking a new medication, it is very important that you make your doctor aware if you are already taking any other medicines. This includes both prescription and non-prescription medications, herbal remedies, vitamins and supplements.

In particular, you should let them know if you are taking any of the following. Trimethoprim may not be suitable for you to use if you are already taking:

  • Digoxin (a medicine for the heart)
  • The antibiotic Rifampicin
  • Any blood thinners, such as Warfarin
  • Repaglinide and Pioglitazone (medicines for diabetes)
  • Phenytoin (a medicine for epilepsy)

If you are currently using Trimethoprim and take the typhoid vaccine orally, it may not work properly. However, if you are given the typhoid vaccine by injection, it should not affect it.

If you have any questions or concerns as to whether this medicine is suitable for you, please do not hesitate to discuss these worries with your doctor before you start to use it.

Pregnancy and breastfeeding

If you are actively trying to get pregnant, it is important that you inform your doctor of this. The use of Trimethoprim in the 12 weeks before pregnancy has been shown to increase the risk of heart and lung defects in new-born babies. 

Inform your doctor if you are currently breastfeeding, pregnant, trying to get pregnant, or think you might be pregnant.

If you are pregnant, you should speak to your doctor about the benefits and risks of taking Trimethoprim during pregnancy, as it is not considered to be the safest medication for pregnant women.

When taken during early pregnancy, it has been linked to small problems for the unborn baby.

A substance called folic acid is very important to the development of an unborn baby, and Trimethoprim lowers the level of folic acid in the bloodstream.

Pregnant women are usually advised to take a 400mcg folic acid supplement every day for the first 12 weeks of their pregnancy. If you need to use Trimethoprim at the same time, your doctor will likely prescribe you a higher dose of folic acid to take.

There are no known risks associated with pregnant women who take Trimethoprim after the first 12 weeks of their pregnancy.

This medicine will pass into your breast milk, but only in small amounts, meaning it is safe to take while you are breastfeeding.

Trimethoprim Ingredients

The main active ingredient within this medicine is: Trimethoprim

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
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Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Medically reviewed by Hussain Abdeh MPharm: 2211840

Updated on: 03/09/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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