Trimethoprim

  • Widely used for the treatment of Urinary Tract Infections (UTI's) such as Cystitis
  • Successfully treats around 9 out of 10 simple bladder infections
  • Stops the growth of bacteria responsible for causing Cystitis
From As low as £14.99
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prescription included

Fast next day delivery

order before 2pm

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347 customer reviews

What is Trimethoprim?

Trimethoprim is an antibiotic medicine that is used in the treatment of urinary tract infections (UTIs), such as cystitis.

It is a prescription only medicine and comes in the form of tablets.

You can buy Trimethoprim 200mg tablets from Medicine Direct's online pharmacy, following an online consultation with one of our certified doctors.

We sell it in packets of 6 tablets.

If you order online before 2pm, we can offer you next day delivery on your treatment.

What is Trimethoprim used to treat?

Trimethoprim 200mg tablets are used to treat people who are suffering from a urinary tract infection, such as cystitis.

It is effective in around 9 out of 10 cases of simple bladder infections and will provide effective treatment for the infection after a few days.

Most cases of urinary tract infections are caused by E. Coli, which originates from your gut. Trimethoprim does not kill E. Coli, it stops the bacterial DNA synthesis so that the bacteria cannot reproduce. This makes it easier for your immune system to fight the infecting bacteria until it is gone from your system and your UTI has been treated.

Other conditions Trimethoprim is prescribed for include acne, traveller's diarrhoea and middle ear infections.

Who can use Trimethoprim?

Trimethoprim is an antibiotic that provides effective treatment for urinary tract infections, but it may not be suitable for everyone to take.

You should inform your doctor if any of the following apply to you:

  • You have any liver or kidney problems
  • You have any blood disorders, including porphyria
  • You have ever had an allergic reaction to Trimethoprim or any other medicines in the past

You have anaemia or low amounts of folic acid (folate) in your blood.

Possible side effects

Like all medicines, Trimethoprim comes with the risk of side effects, although not everyone who takes this medication will experience them.

Side effects are very rare in people who use Trimethoprim; some people do develop a skin rash, but these will usually only be mild and should go away when you stop taking the medication.

Common side effects include:

  • An itching or mild rash
  • Feeling sick
  • Headaches
  • Diarrhoea
  • Hives
  • Thrush
  • Diarrhoea

Please note, this list is not exhaustive. Please refer to the Side Effects tab on this page, for a list of rarer and more serious adverse reactions you may experience while taking this medication.

Where can I buy Trimethoprim online safely?

Never order any medicine online unless it is from an online pharmacy that is registered with the General Pharmaceutical Council (GPC), like Medicine Direct.

All of our doctors are registered with the General Medical Council (GMC), which means they can prescribe medicine just like your local GP. After an online consultation, they will prescribe you the medicine they deem the most suitable for your condition, which you can then order from our pharmacy.

If you order online with us before 2pm, we can offer you next day delivery on your medication.

Trimethoprim Dosage

Always take Trimethoprim 200mg tablets exactly as instructed by your doctor. Read the patient information leaflet thoroughly before you start using a new treatment. Speak to your doctor or pharmacist if you are unsure of how to take Trimethoprim.

The dose of Trimethoprim you will need to take will depend on why you have been prescribed it.

As a treatment for UTIs, the usual dose for adults and children over 12 years is Trimethoprim 200mg, which should be taken twice daily. Your doctor may suggest you double the dose to 400mg when you take Trimethoprim for the first time. Only double your dose if told to do so.

If you are elderly or have any kidney problems, the dose may be lower for you.

It is very important that you keep taking Trimethoprim until your course of treatment is complete, even if you feel better before then.

Stopping your treatment early could mean that the infection comes back.

How to take it

Trimethoprim tablets should be swallowed whole with a drink of water. Do not break, crush, or chew the tablets.

If you find it difficult to swallow, you can also buy this medicine in the form of a liquid.

When taking Trimethoprim to prevent an infection, take the pill before bedtime.

How long will I need to take it for?

How long you will need to take Trimethoprim will depend on your age, where your infection is and how bad it is. It will also depend on your sex and whether you have any existing health problems.

  • Women who have simple UTIs will normally require a course of treatment for 3 days.
  • Men and pregnant women with simple UTIs will normally need to take it for 14 days.
  • Anyone with complicated or severe UTIs, or a catheter, will also need to take it for 14 days.
  • If the UTI causes a man's prostate gland to swell, they may require treatment for 4 to 6 weeks.
  • To prevent UTIs, treatment may last for 6 months, as it may do for treating acne.

Do not stop using this medication until your course is complete, even if you feel better before then.

What if I forget to take it?

If you accidentally miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose.

If it is closer to your next dose than your missed one, skip the dose you missed and continue taking Trimethoprim as usual.

Never double dose in an attempt to make up for missing a previous dose.

To get into the routine of taking this medication, it is best if you take it at the same time every day to avoid forgetting it. Some people find it helps them to set an alarm as a reminder.

What if I take more than I am supposed to?

Accidentally taking an extra dose of Trimethoprim 200 mg is not likely to do you any harm. However, it may increase your risk of temporary side effects, such as diarrhoea, nausea, or vomiting.

If you get severe adverse effects, become worried, or have taken more than one extra dose of this medicine, you should speak to your doctor.

Trimethoprim FAQ's

Can Trimethoprim be bought online and without a prescription?


This treatment cannot be bought online without prescriptions. However, it is possible to order Trimethoprim online from Medicine Direct, following an online consultation with one of our certified doctors.

All of our doctors are registered with the General Medical Council, meaning they can prescribe medicine just like your local GP.

Following your online consultation, they will assess your symptoms and prescribe Trimethoprim if they believe it to be the most suitable course of treatment for you. You can then order this medicine from our pharmacy.

Never order medicine online unless it is from a registered pharmacy, like Medicine Direct. We are registered with the General Pharmaceutical Council (GPC), which means we can guarantee genuine medicines from our online pharmacy.

Can I drive or operate machinery?


Taking this medicine should not impair your ability to drive, ride a bike or operate machinery. If you experience feelings of dizziness, tiredness or nausea, which are side effects associated with Trimethoprim, you should not do any of the above until you feel better.

What should I do if I don't get better?


If you don't feel any better after taking the medication for 3 days, or if you start to feel worse, go back to your doctor.

Will Trimethoprim give me thrush?


Antibiotics that include trimethoprim as an ingredient will reduce the bacteria in your body. After you have completed a course of antibiotics, the bacteria in your vagina can be reduced greatly, which can cause the natural fungus to overgrow and cause thrush. If this occurs while you use this medicine, speak to your doctor for advice. They will be able to recommend a treatment.

Is Trimethoprim stronger than amoxicillin for a UTI?


Research suggests that Trimethoprim is more effective and has less side effects than Amoxicillin.

How long does it take for Trimethoprim to work for a urinary tract infection?


For women who have simple UTIs, it will normally take 3 days of treatment to relieve your infection. Men and women who are pregnant will probably need to take it for 14 days.

Can I combine Trimethoprim and alcohol?


Yes, it is safe to drink alcohol while taking this medication, although the tablets should only be taken with water.

Trimethoprim Side Effects

Only 1 in every 1,000 people is likely to experience a serious side effect while taking Trimethoprim.

Speak to your doctor as soon as possible if you suffer any of these rare side effects:

  • Anorexia
  • Depression, anxiety, nightmares, or difficulties in sleeping
  • Involuntary movements
  • Convulsions
  • Feeling dizzy or tired
  • Kidney problems
  • Purple skin discolouration
  • Anaemia
  • Soreness in your mouth or tongue
  • Reduction in the number of blood cells
  • Lupus erythematosus
  • Sore throat
  • Feeling confused or suffering hallucinations
  • Joint or muscle ache
  • Tremors, shaking, or pins and needles
  • Skin becoming sensitive to the sun
  • Low blood sugar

You should call your doctor straight away if you exhibit any of the following symptoms:

  • You have chest pains, an abnormal heartbeat, muscle weakness, or are feeling or being sick – this could be high potassium in your blood
  • You have a serious skin reaction which may include swelling that looks like burns, round red patches, peeling, skin ulcers, or blisters
  • You have unexplained bruising or bleeding, mouth ulcers, a sore throat, a high temperature, tiredness or generally feel unwell – these could be signs of a blood problem
  • You have diarrhoea that contains blood or mucus, or if you have severe diarrhoea that lasts for longer than 4 days

If you have tiredness, a fever, headaches, a stiff neck, you feel ill, or your eyes become very sensitive to light, you should stop taking this medicine and either call 999 or go to A&E straight away. Any of these symptoms could be a sign of meningitis.

Serious allergic reaction

In rare cases, it is also possible that you may suffer a serious allergic reaction to Trimethoprim. You could require immediate treatment in hospital.

You should either call 999 or go to A&E as soon as possible if you exhibit any of the following symptoms:

  • You have swelling in your face, throat, mouth, tongue, or lips
  • You are wheezing
  • You get tightness in your chest or throat
  • You are finding it difficult to speak or breathe
  • You have a skin rash that is red, itching, swollen, blistered or peeling skin

Please note, the above lists may not be exhaustive. Always read the patient information leaflet, which will accompany your medicine, thoroughly, before you start to take it.

If you have any questions or concerns at all, you should not hesitate to discuss them with your doctor.

Trimethoprim Warnings and drug interactions

Trimethoprim does not mix well with several other types of medicine.

Before taking a new medication, it is very important that you make your doctor aware if you are already taking any other medicines. This includes both prescription and non-prescription medications, herbal remedies, vitamins and supplements.

In particular, you should let them know if you are taking any of the following. Trimethoprim may not be suitable for you to use if you are already taking:

  • Digoxin (a medicine for the heart)
  • The antibiotic Rifampicin
  • Any blood thinners, such as Warfarin
  • Repaglinide and Pioglitazone (medicines for diabetes)
  • Phenytoin (a medicine for epilepsy)

If you are currently using Trimethoprim and take the typhoid vaccine orally, it may not work properly. However, if you are given the typhoid vaccine by injection, it should not affect it.

If you have any questions or concerns as to whether this medicine is suitable for you, please do not hesitate to discuss these worries with your doctor before you start to use it.

Pregnancy and breastfeeding

Inform your doctor if you are currently breastfeeding, pregnant, trying to get pregnant, or think you might be pregnant.

If you are pregnant, you should speak to your doctor about the benefits and risks of taking Trimethoprim, as it is not considered to be the safest medication for pregnant women.

When taken during early pregnancy, it has been linked to small problems for the unborn baby.

A substance called folic acid is very important to the development of an unborn baby, and Trimethoprim lowers the level of folic acid in the bloodstream.

Pregnant women are usually advised to take a 400mcg folic acid supplement every day for the first 12 weeks of their pregnancy. If you need to use Trimethoprim at the same time, your doctor will likely prescribe you a higher dose of folic acid to take.

There are no known risks associated with pregnant women who take Trimethoprim after the first 12 weeks of their pregnancy.

This medicine will pass into your breast milk, but only in small amounts, meaning it is safe to take while you are breastfeeding.

Trimethoprim Ingredients

Trimethoprim is the active substance contained within this medicine.

Other inactive ingredients also contained within this medicine are: colloidal silicon dioxide, lactose, macrogol, magnesium stearate, povidone, sodium starch glycolate, stearic acid, microcrystalline cellulose (E460).

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

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