Differin Cream

  • Prescribed for the treatment of acne
  • Reduces redness and irritation of the skin
  • Visibly reduces the symptoms caused by acne
From As low as £28.99
All-inclusive service

prescription included

Fast next day delivery

order before 2pm

UK registered pharmacy

and team of dispensers

TrustScore 4.8

347 customer reviews

What is Differin cream?

Differin cream contains the active ingredient adapalene, which is a form of vitamin A. It reduces the growth of keratin skin cells, which normally act to block pores, resulting in acne vulgaris.

You can buy Differin at Medicine Direct's online pharmacy following an online consultation with one of our certified doctors, who will prescribe you this cream if they believe it to be a suitable treatment for you to use.

The dosage is 0.1% and Differin Cream is available in packs of 1 x 45g tube, 2 x 45g tubes, or 3 x 45g tubes.

Next day delivery is available if you order before 2pm.

Differin gel is also available on prescription.

What is Differin cream used to treat?

Differin cream is largely prescribed as an acne treatment.

Adapalene has an anti-inflammatory effect, which helps to reduce soreness and irritation, meaning it is effective in reducing redness and inflammation caused by acne spots.

Differin is absorbed into the body in small amounts and has little effect anywhere apart from the surface of your skin. This makes it an effective acne treatment for the physical symptoms caused by acne.

Who can use Differin?

Differin is an effective acne treatment, but it is not suitable for everyone to use.

Do not use Differin if you are allergic to adapalene or any of the other ingredients contained in the medicine (please see the Ingredients tab for full details).

This treatment is not recommended for women who are pregnant. If you are currently pregnant, are trying to get pregnant, or think you might be pregnant, you should inform your doctor.

Differin is safe to use while breastfeeding. However, to avoid the treatment from being ingested by your baby, you should not apply it to your chest.

Do not use this medicine alongside any other products to treat acne that contain benzoyl peroxide, erythromycin or clindamycin.

Possible side effects

Like all medications, Differin does come with the risk of some side effects, although these will not affect everybody who uses the cream.

Common side effects include:

  • Dry skin
  • Irritation of the skin
  • Skin redness
  • Burning of the skin

Speak to your doctor if any of these symptoms bother you or do not go away.

This list is not exhaustive. For a list of more serious reactions, refer to the Side Effects tab on this page. Always read the patient information leaflet thoroughly for a complete list of adverse effects associated with this medication.

Differin Cream Dosage and Directions

Always follow your doctor's instructions precisely and read the patient information leaflet thoroughly before using Differin. Check with your doctor or pharmacist if you are unsure of anything, before applying this treatment.

This acne treatment is for external use only. Avoid contact with the eyes, mouth or angles of the nose. Do not apply the medicine to any areas on your body that have cuts, scrapes or sunburnt skin. Do not apply Differin to anywhere that is affected by skin conditions like eczema.

Apply the cream to your skin at night before you go to bed, unless instructed to do otherwise by your doctor.

How to apply Differin

Thoroughly wash the affected area(s) of skin with water. Make sure the skin is clean and dry before using Differin.

Apply a thin layer of the cream to your fingertip and gently rub it into the affected area(s).

Wash your hands with soap and water after you have applied the treatment to your skin.

Do not stop the treatment until you have finished the course set out by your doctor. If you stop applying Differin before your course is complete, your acne may flare up again.

How long will I need to use it for?

How long you will need to apply Differin for will depend on how quickly your acne symptoms begin to improve. You should not use this acne treatment for longer than 3 months without speaking to your doctor. The doctor will be able to see how your skin is responding to the cream and whether your acne is beginning to improve.

What if I apply more than I am supposed to?

An extra dose of Differin is unlikely to do you any harm. If you apply too much, just wash the cream off. Applying extra doses of Differin will not clear up your acne any faster and your skin may become irritated or red. Your skin may also peel.

Seek medical advice if you accidentally swallow some of this medicine.

What if I forget to apply it?

If you forget to apply Differin, don't worry, just apply the treatment the next night.

To effectively treat acne on your skin, it is important you are consistent with your application of Differin. Some people find it helpful to set an alarm before bed, to remind them to apply the treatment to their skin.

How to store

Store this medicine in a cool, dry place. Keep it out of sight and reach of children.

Do not keep using Differin if it has passed its expiry date

How does Differin work?


Differin contains adapalene, which has an anti-inflammatory effect. This helps to reduce the redness and irritation associated with the physical symptoms of acne. Adapalene is a form of vitamin A, which reduces the growth of keratin skin cells, which normally act to block your pores, resulting in acne vulgaris.

Is it safe to buy online?


This medicine is available to purchase at Medicine Direct's online pharmacy when you have a prescription from one of our certified doctors. After an online consultation, a doctor will prescribe you Differin if they believe it is a suitable treatment for your acne.The dosage is 0.1% we sell it in packs of 1 x 45g tube, 2 x 45g tubes, or 3 x 45g tubes. Next day delivery is available if you place your order before 2pm. To safely purchase medicine online, you should only order with an online pharmacy that is registered with the General Pharmaceutical Council, like Medicine Direct. Differin gel is also available on prescription; you should only purchase Differin gel if you have a prescription from a doctor.

What are the advantages of buying Differin online?


When you purchase this medicine from our online pharmacy, we can offer you a fast delivery (next day delivery is also available if you order before 2pm). One of our certified doctors will give you a prescription for Differin, following an online consultation, removing the need for you to leave the house for a consultation.We are a registered pharmacy and promise you nothing but genuine medicine, prescribed by certified health professionals.

Is Differin suitable for me?


This treatment may not be suitable for everyone who suffers from acne. Differin is only available to purchase if you have been prescribed it by your doctor. Inform your doctor if you are already using any acne treatments that contain benzoyl peroxide, erythromycin or clindamycin. You should not use this medicine if you are pregnant or think you might be pregnant. It is safe to use while breastfeeding, but you should not apply Differin to your chest, to ensure that your baby does not ingest the treatment. Differin gel is also available.

What's a good treatment plan?


Your doctor will advise you on how to use this medicine. It should be applied in the evening before bed; to ensure effective treatment for your acne, you should be consistent with the treatment's application.

Differin Cream Serious Side Effects

The below are uncommon side effects of Differin, which may affect up to 1 in every 100 people:

  • Local skin reaction
  • Sunburn
  • Skin discomfort
  • Skin peeling
  • Itching
  • Flare up of acne

It is not known the frequency of these reactions:

  • Allergic contact reaction
  • Irritation, redness, itching or swelling of the eyelids
  • Pain or skin swelling

Report any of these side effects to your doctor.

In rare cases, you may suffer a severe allergic reaction to Differin and require immediate treatment in a hospital. You should either go to A&E or call 999 straight away if you experience any of the following symptoms:

  • You are wheezing
  • You have swelling in the lips, mouth, throat, face or tongue
  • You have a skin rash that is blistered, peeling, itchy, red or swollen
  • You are finding it difficult to speak or breathe
  • You have tightness in your chest or throat

Always read the patient information leaflet thoroughly before you start to use Differin, for the full list of side effects and reactions. If you have any concerns or questions, you are advised to speak to your doctor before you start to take Differin.

Differin Cream Warnings and drug interactions

Differin may interact with other drugs, which can increase your risk of side effects and hinder the effectiveness of this treatment on your acne.

Before you start to take a new medicine, you should always tell your doctor and pharmacist if you are already taking any other medicines. This includes both prescription and non-prescription medication, herbal remedies, vitamins and supplements.

Make sure your doctor is aware if you are already taking any of the following:

  • Any other products to treat acne that contain benzoyl peroxide, erythromycin or clindamycin
  • Cosmetics can be used as long as they do not cause blackheads or dry skin

You should avoid exposure to strong sunlight and artificial UV light (such as sunbeds) while using this medication. If you experience any sensitivity or irritation while applying Differin, stop using it and speak to your doctor. They may advise you to use it less often or stop using it altogether for a short period of time.

Only ever purchase Differin online if it is from a registered online pharmacy like Medicine Direct. We are registered with the General Pharmaceutical Council, meaning we can promise you nothing but genuine medication. Next day delivery is available if you order before 2pm.

To ensure the effectiveness of Differin, you should always follow your doctor's instructions precisely when applying it. Do not stop using the medicine until you have completed the course laid out by your doctor.

If you have any concerns or questions at all about any aspect of using this medicine, we strongly advise you to discuss these with your doctor before you start to apply Differin.

Differin Cream Ingredients

The active ingredient contained in this treatment is adapalene.

Differin also contains 0.1% w/w of adapalene and the other ingredients are carbomer 934P, macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalane, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide and purified water.

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

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This content has been written by our Pharmacist Sonia Khan and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh

Sonia Khan
MPharm: 2076091

Pharmacist

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