- Reduces the appearance of spots
- Reduces redness and inflammation
- Removes blackheads
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What is Differin gel?
Differin gel is a topical gel that is renowned for treating the symptoms of acne.
It contains a retinoid medicine called adapalene, which is a form of vitamin A and helps to increase skin cell turnover and reduce the growth of keratin skin cells that normally block the pores and cause acne.
You need a prescription to buy Differin gel online. It is suitable for adults and children over the age of 12.
What is Differin gel used to treat?
Differin is a popular treatment for acne symptoms. It is also available as Differin cream, which works in the same way as the gel, but may be more suitable for sensitive skin. The gel version is better suited to people who have oily skin as it dries faster.
Acne is a chronic inflammatory skin condition that most commonly occurs on the face, neck, shoulders, chest or back. Although it can occur at any age, it is most likely to affect people going through puberty, as it is often caused by hormonal changes in the body.
Sometimes, acne will go away on its own. However, if it is severe or does not go away in time, many people are prescribed a medical treatment like Differin gel to help target the cause of the issue. Seeking medical attention for your acne helps to tackle the problem faster and also reduces the risk of scarring.
How does Differin gel work for acne?
Differin gel contains the active ingredient adapalene, which is a type of vitamin A. This gel works by reducing the growth of skin cells on the surface of the skin (keratin). These skin cells can block your pores along with a substance called sebum and cause acne.
Sebum is produced naturally by your sebaceous glands; it is an oily substance that helps to keep the skin supple and smooth. However, acne can often be the result of an overproduction of sebum, which mixes with the dead keratin skin cells and block the pores. When pores are blocked, they become inflamed, which can cause spots, blackheads and whiteheads to form.
Differin reduces the number of keratin skin cells, which helps to unclog the pores. This lets the sebum escape, which reduces inflammation and spots, whiteheads and blackheads.
Furthermore, Differin increases skin cell turnover, which further helps to exfoliate the skin’s natural layers and reduce the risk that the pores will become blocked again.
How to use Differin gel
Always follow your doctor’s instructions when using any medication. Read the patient information leaflet for detailed instructions before you use Differin for the first time.
Differin gel is for external use only. Do not apply it internally or swallow the gel.
Apply Differin gel in the evening before you go to bed.
- Wash the affected areas thoroughly with water before applying the gel.
- Apply a thin film of gel to the affected areas with your fingertip. Rub it in gently.
- Wash your hands after you have applied Differin gel.
Who can use Differin gel?
Differin gel is not suitable for you if:
- You are allergic to adapalene or any of the other ingredients contained in this medicine (please see the Ingredients tab for full details)
- You are pregnant
- You are trying to get pregnant
You can read more about precautions to take while using Differin gel on the Warnings tab on this page.
As ever, you should read the patient information leaflet for a full list of reasons why this medicine may not be suitable for you to use.
Can you buy Differin gel over the counter?
No, Differin gel is not for sale over the counter. It must be prescribed by a doctor.
Can you buy Differin gel online in the UK?
Yes, you can buy Differin gel online in the UK, but you should only do so from regulated pharmacies, like Medicine Direct. This will ensure you buy only genuine and approved versions of any medicine you need.
Before you can order Differin gel from Medicine Direct, you will need to have an online consultation to make sure that this medicine is suitable for you. This involves filling out a confidential questionnaire, which will be reviewed by a registered pharmacist, doctor or prescriber, who will review your condition and answers to ensure this is the right treatment for you.
Differin gel alternatives
Differin cream is also available. This medicine also contains adapalene and works in the same way as the gel but is better suited to people with dry or sensitive skin.
A range of other topical acne treatments are also available to be ordered from Medicine Direct after an online consultation. These include:
- Acnecide gel
- Epiduo gel also contains the same active ingredient and is available to buy online from Medicine direct.
- Zineryt lotion
- Duac gel
- Finacea gel
We stock oral medications for acne too, including antibiotics like Erythromycin, Tetralysal and Minocycline.
Differin Gel Indications and Dose
All of our prescribers follow NICE guidelines when prescribing Differin Gel.
If you forget to use it
If you miss an application of Differin gel, apply it as soon as you remember. Do not apply a double dose to try and make up for missing an earlier one.
If you use too much gel
Using more than the recommended dose will not work to treat your acne any faster. However, it may cause skin redness, irritation, peeling or discomfort.
Speak to your doctor if this occurs.
How to store Differin
Store this medicine out of the sight and reach of children.
Store in the original container in temperatures below 25C. Do not freeze.
Do not use the gel if it has passed the expiry date stated on the carton and tube. The expiry date is the last day of the month stated.
Ask your pharmacist about how to dispose of any gel you may have remaining at the end of treatment. This will help to protect the environment. Do not dispose of remaining medicine via wastewater or household waste.
How long does Differin gel take to work?
Can Differin gel help to treat scars?
Should I wash Differin gel off in the morning?
Can Differin treat hormonal acne?
Can you apply Differin gel under the eyes?
Can Differin gel improve wrinkles?
Should you moisturise before or after using Differin?
Can Differin make my acne worse?
Does Differin work to fade dark spots?
Does Differin make your face red?
Differin Gel Side Effects
Like any medicine, Differin gel can cause side effects. However, not everyone who uses this gel will experience an adverse reaction to it.
Doing a patch test is advisable before you start using a new topical treatment, as this will check to see if you are allergic to the medicine.
Tell your doctor if you experience any side effects while using Differin gel.
Common Side Effects
The common side effects of Differin may affect up to 1 in 10 people:
- Burning sensation of the skin
- Dry skin
- Skin redness
- Skin irritation
Uncommon side effects may occur in up to 1 in 100 people:
- Skin peeling
- Skin discomfort
- Local skin reaction (contact dermatitis)
The following side effects may occur at an unknown frequency:
- Lightening of darker skin
- Darkening of fair skin
- Skin pain or swelling
- Allergic contact reaction
- Eyelids become red, irritated, swollen or itchy
- Burning at the site of application
In rare cases, it is possible to have an allergic reaction to medicine. If you get any of the following symptoms, you should seek medical attention immediately:
- A skin rash that may be red, itchy, swollen, blistered or peeling skin
- Difficulty in breathing or talking
- Swelling in your mouth, face, lips, tongue or throat
- Tightness in your chest or throat
You may need to be treated in hospital.
Always read the patient information leaflet before you start using Differin gel for a full list of side effects. The leaflet will also provide guidance on what to do if you get any.
Differin Gel Warnings and Drug Interactions
Tell your doctor or pharmacist if you are currently taking any other medication, including medicine you can buy without a prescription. They should also know if you are planning to take any other medicine while using Differin gel.
You can use other medicines to treat acne (containing erythromycin, clindamycin or benzoyl peroxide). However, these must be applied in the morning and Differin must be applied at night.
You can use cosmetic products as long as they do not cause dry skin or blackheads.
If applying the gel to your face, avoid contact with the eyes, nostrils and mouth. If the gel accidentally gets into any of these areas, rinse thoroughly with warm water. If you suffer any vision problems or pain after this, seek medical attention.
Avoid exposure to sunlight and UV light (such as sunbeds) while using Differin gel.
Do not apply Differin gel to any areas of skin that have cuts or scrapes. It should also not be applied to areas affected by eczema.
Tell your doctor if you find that this gel makes your skin irritated or sensitive. You may need to use it less frequently, or even stop using it until your skin settles down.
Differin contains propylene glycol, which may cause skin irritation. It also contains methyl parahydroxybenzoate, which can cause allergic reactions.
Pregnancy and breastfeeding
Do not use Differin gel if you are pregnant or planning to get pregnant.
You will need to stop using this medicine if you become pregnant during treatment. Tell your doctor straight away if this happens.
You can use Differin gel while breastfeeding, but do not apply it to your chest to ensure the baby doesn’t come into contact with the medicine.
See the patient information leaflet for full details on warnings and precautions. Ask your doctor or pharmacist if you have any questions or concerns.
Differin Gel Ingredients
The main active ingredient within this medicine is: Adapalene
For a full list of the inactive ingredients, please read the Summary of Product Characteristics
How it works - get your medicine in 3 simple steps
- 1 Choose your treatment Select the treatment or medication you need and answer a few questions online regarding your condition.
- 2 Online consultation Our Independent Prescribers will review your questions and assess your suitability for the medication.
- 3 Receive your delivery Your medication is dispensed and delivered directly to you from our UK based Pharmacy.