Duac Gel

  • Treats mild to moderate acne
  • Visible improvements between 2 and 4 weeks
  • Kills the bacteria responsible for spreading acne
From As low as £21.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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prescription included

Fast next day delivery

order before 2pm

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What is Duac?

Duac Once Daily Gel is a topical acne treatment for mild to moderate cases.

You can buy Duac Once Daily Gel from Medicine Direct after a simple and confidential online consultation with one of our certified doctors. After reviewing your symptoms and medical history, they will give you a prescription for this product if they believe it to be the most suitable one for you to use.

You can then order the gel from our UK registered pharmacy; place your order by 2pm and you will also receive next day delivery on your medication.

Duac Gel for acne

Duac Gel is an effective treatment for mild to moderate cases of acne. Generally, people who use this product to treat acne will start to notice initial results after using Duac once a day for between 2 and 4 weeks.

Most people who have a long history of suffering with acne, Duac has proven to be very effective. Your skin should have cleared up completely after using Duac for three months. After this period of time, you are normally advised to keep applying the gel to the skin to prevent the problem from coming back.

If you cannot take oral treatments, Duac Gel makes an excellent and effective alternative.

How does Duac work?

Duac Once Daily Gel is a topical antibiotic that contains two medicines, clindamycin and benzoyl peroxide. These active ingredients work together to kill the bacteria that is responsible for spreading acne.

Most people who use it will notice an improvement after between 2 and 4 weeks of using the gel once a day.

Clindamycin and benzoyl peroxide

Clindamycin is a medicine known as a macrolide antibiotic, and is one of the most common antibiotics prescribed for the treatment of acne. It works by stopping the bacteria in acne from reproducing.

Benzoyl peroxide removes blockages in the pores of your skin; it also has antibacterial properties. After clindamycin has stopped the bacteria from reproducing, benzoyl peroxide can then kill the bacteria, which reduces pimples and acne.

When used together, these two medicines can also help to treat existing whiteheads and blackheads.

Duac Gel for acne scars

Some people find that a secondary benefit of Duac is that it is able to lessen the appearance of acne scars on the skin. Acne scars are generally difficult to treat, but they do tend to fade over time.

To lessen the risk and severity of scarring, you should not pop or pick your spots.

Who can use Duac Gel?

Do not use this medicine if you are allergic to benzoyl peroxide, clindamycin or any of the other ingredients contained in the gel (please refer to the Ingredients tab for full details).

Speak to your doctor or pharmacist before using this treatment if you have or have ever had any of the following gut conditions:

  • Ulcerative colitis
  • Regional enteritis
  • Antibiotic-associated colitis

This treatment is not suitable for children who are under the age of 12.

Tell your doctor or pharmacist if you are due to have surgery. Duac can affect certain general anaesthetics.

What alternatives are there to Duac?

Over the counter medicines may be enough to control your acne. Benzoyl peroxide is a common ingredient in pharmacy treatments for acne, so you may find that you do not need a prescription-only medication like Duac to control the problem.

Medicine Direct stocks various treatments for this skin condition.

Dosage and Directions

Our pharmacists and prescribers follow NICE prescribing guidelines when prescribing Duac Gel.

Always apply Duac Once Daily Gel as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly and speak to your doctor or pharmacist for guidance if you are still not sure.

Use Duac once a day in the evening.

The gel should be rubbed into the skin easily; if you cannot rub it into your skin, this means you are using too much.

Do not use this product for longer than 12 weeks at a time. Your doctor will advise you as to how long you should use this medication.

How to use Duac

  1. Remove any makeup you are wearing.
  2. Wash the affected area of skin well, then rinse with warm water and pat completely dry.
  3. Using your fingertips, apply a thin layer of gel to the whole of the affected area.
  4. Apply the gel to the whole area, not just to individual spots.
  5. Wash your hands after you have applied the gel.

If you find that you get skin dryness or peeling, you can use an oil-free, fragrance free, hypoallergenic moisturiser. Your doctor may advise you to use the product less frequently, or pause the treatment so your skin can adjust.

Is Duac an effective acne treatment?

Duac Gel has proven to be an incredibly effective medicine to treat acne. Typically, people will start to notice an improvement after using it each day for between 2 and 4 weeks. After three months, your skin should be completely clear.

Should I keep using my moisturiser?

It is recommended to use an alcohol-free moisturiser while using Duac Gel. Using a moisturiser will help to keep the skin hydrated and ease the peeling or dryness that some people suffer while using this prescription treatment.

Will using Duac cause dry skin?

Dry skin occurs in 1 in 10 people who use it; this problem may cause red or peeling skin and is likely to be made worse by other medicines, soaps or skin products you are also using. Any products that contain isotretinoin, tretinoin and tazarotene may interact with benzoyl peroxide and irritate the skin. If you have to use any other products, try to apply them at different times during the day.

How should I store Duac?

Store out of sight and reach of children. Do not store above 25C and do not keep using once opened for longer than two months.

Can I still drink alcohol when using Duac?

This medicine will not react with drinking alcohol, although it may cause adverse reactions if used alongside topical products that also contain alcohol.

How will Duac Gel benefit me?

Duac can provide effective and long term treatment for acne. It helps to kill the bacteria that causes this problem, helping to reduce your chances of suffering from spots again in the future. It also works faster than other medicines and decreases your chance of adverse effects, due to it being applied directly to the skin. You should start to notice a difference after a few weeks.

Can I buy Duac over-the-counter?

You must have a prescription to purchase this gel. You can order Duac Gel online from Medicine Direct after a consultation with a doctor. They will give you a prescription for this product if they deem it appropriate for you. From there, you can buy the treatment from our UK registered online pharmacy.

If I use Duac will my skin dry out?

Around 1 in 10 people who use this medication will suffer from dry skin, particularly if they are also using topical products that contain isotretinoin, tretinoin or tazarotene. If you need to use a product that contains any of these, try to apply them at a different time to Duac. You can use an alcohol-free moisturiser to help to resolve this problem if you do suffer from it.

Is Duac once daily gel?

Yes, to effectively treat acne breakouts, you should use this topical medication once a day.

Is Duac safe during pregnancy?

Speak to your doctor before using this product if you are pregnant, trying to get pregnant or think you might be pregnant.

How Is Duac applied?

Apply a thin layer to the whole of the affected area once a day.

Can I apply more Duac Gel?

Always apply Duac as instructed by your doctor. Do not exceed the dose they state. Your acne will not improve any faster by applying more gel; this may lead to resistance and can cause skin irritation.

How long does Duac take to work?

You should start to see an improvement within the first month of using this medicine.

Side effects

Like all medicines, Duac Once Daily Gel comes with the risk of certain side effects, although not everyone gets them.

Common side effects of Duac include:

  • Redness, peeling or dryness of the skin
  • Headaches
  • Burning, pain or sensitivity to sunlight

Some people may experience:

  • Tingling
  • Worsening of acne
  • Red, itchy skin
  • Rash

Speak to your doctor or pharmacist if any of these reactions bother you or do not go away.

Please refer to the Side Effects tab for rarer reactions.

Serious Side Effects

You should stop using this gel and seek medical attention if you suffer any of the following side effects of Duac:

  • Severe or prolonged abdominal cramps or diarrhoea (including bloody diarrhoea)
  • Inflammation of the intestine

In rare cases you may suffer a severe allergic reaction and require immediate treatment in hospital. Stop using the gel and call 999 or go to A&E straight away if:

  • You develop a skin rash that may have red, itchy, swollen, blistered or peeling skin
  • You are finding it difficult to breathe or speak
  • You have swelling in your face, mouth, throat, tongue or lips
  • You have tightness in your chest or throat
  • You are wheezing

Always read the patient information leaflet for full details on side effects

Warnngs and Drug Interactions

Inform your doctor if you are already taking any of the following:

  • Any other form of acne treatment
  • Any medicated or 'abrasive' soaps or cleansers
  • Soaps or cosmetics that have a strong drying effect
  • Any products containing large amounts of astringents or alcohol
  • Any products that contain tretinoin, isotretinoin or tazarotene
  • Any medicines containing erythromycin

For more information on medicines that interact with Duac Gel.

Do not use this treatment for more than 12 weeks at a time.

Using Duac at the same time as a product containing dapsone and sulfacetamide can cause temporary skin or facial hair discolouration.

If you suffer from severe skin irritation, stop using this treatment and speak to your doctor.

This medicine is for topical use only - keep it away from your eyes, lips, mouth and nostrils. If the treatment comes into contact with any of these areas, rinse thoroughly with clean water.

Do not use on infected or broken skin, cuts or sores.

This prescription medication can bleach fabrics; keep away from clothes and bed linen.

Pregnancy and breastfeeding

There is only limited information available as to whether Duac Once Daily Gel is suitable to be used by women who are pregnant or breastfeeding.

For this reason, you should inform your doctor or pharmacist if you are currently pregnant, think you might be pregnant, are trying to get pregnant or are breastfeeding, before you start to use this gel.


Duac's active ingredients are: clindamycin phosphate, equivalent to clindamycin 1 % w/w (10 mg/g) and hydrous benzoyl peroxide, equivalent to anhydrous benzoyl peroxide 5 % w/w (50 mg/g).

Inactive ingredients also contained are: carbomer, dimeticone, disodium lauryl sulfosuccinate, disodium edetate, glycerol, silica, colloidal hydrated, poloxamer 182, purified water and sodium hydroxide.

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

This page has recently been medically reviewed by Hussain Abdeh MPharm: 2211840

Updated on: 20/05/2021

This content has been written by James Nuttall and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh.

Superintendent pharmacist Hussain Abdeh at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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  • 2 Online consultation Our Independent Prescribers will review your questions and assess your suitability for the medication.
  • 3 Receive your delivery Your medication is dispensed and delivered directly to you from our UK based Pharmacy.

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