Efracea Modified Release Capsules - 40mg

  • Effectively treats Rosacea
  • Contains the powerful antibiotic Doxycycline
  • Reduces redness and irritation
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What is Efracea 40mg Modified Release Capsules?

Efracea contains the active ingredient doxycycline, which belongs to a group of medicines known as tetracycline antibiotics. Efracea is a slow-release formulation which can be used in the treatment of rosacea.

It is a prescription-only medicine and is suitable to be taken by adults and children who are aged 12 and above.

How does Efracea work?

Orally taken antibiotics such as Doxycycline, reduce the inflammatory lesions, papules and pustules caused by rosacea. It also helps to reduce some of the main symptoms of rosacea, facial erythema; which is responsible for redness and swelling of the face.

Doxycycline is a very diverse antibiotic, when used to treat acne and rosacea, during clinical trials it displayed a 80-100% success rate at clearing inflammatory lesions of rosacea.

Doxycycline also reduced the symptoms of facial erythema of rosacea by 50% over a 4 week period.

Efracea is usually prescribed for an initial 6 week period, during which your symptoms and side effects will also be monitored. The course can be extended to 16 weeks if rosacea symptoms respond well to Efracea.

As Rosacea is a chronic lifelong condition, the long term use of antibiotics is not recommended as this restricts the body’s natural development and resistance to bacteria.

How do I take Efracea?

Recommended daily dose

Doxycycline Dosage for Rosace - NICE

Rosacea 100mg once daily
Papulopustular facial rosacea 40mg once daily for 16 weeks, review after 6 weeks if no improvement to symptoms

Take this medicine on an empty stomach, ideally at least one hour before a meal, or two hours after eating.

Directions of use

Swallow the capsules whole with a drink of water. Do not crush or chew them. Make sure you have a sufficient amount of water, to ensure that the capsules travel down your throat properly. This will avoid throat irritation.

To further avoid any throat irritation, it is best to be sat up straight or standing while taking Efracea.

Keep taking Efracea until your doctor tells you to stop.

We recommend thoroughly reading the patient information leaflet that will detail full step-by-step directions to take your medicine safely.

Who can use Efracea?

Efracea is an effective treatment for rosacea, but it may not be suitable for everyone to use.

Do not take Efracea if any of the below apply to you:

  • You are allergic to doxycycline or any of the other ingredients contained in this medication (please refer to the Ingredients tab for full details)
  • You are allergic to any other medicine in the tetracycline family, including doxycycline and minocycline
  • You have a condition that causes a lack of acid in the stomach called achlorhydria
  • You have had surgery on the upper part of your gut

Efracea is not suitable for infants or children under the age of 12 years old.

Speak to your doctor before taking Efracea if:

  • You have colitis
  • You are prone to or have a history of candidiasis overgrowth
  • You have a fungal, oral or vaginal yeast infection
  • You have liver disease
  • Your doctor has told you that you are intolerant to certain sugars
  • You suffer from the muscle disease myasthenia gravis
  • You suffer from a form of rosacea which affects your eyes
  • You have oesophageal irritation or ulceration
  • You expose your skin to excessive/strong or artificial sunlight

For more information on who this treatment may or may not be suitable for, please read the patient information leaflet.

Common side effects of Efracea modified release capsules

Common side effects of taking Efracea may include:

  • Fungal infections
  • Inflammation of the sinuses
  • Inflammation of the nose and throat
  • Pain
  • Back pain
  • Anxiety
  • High or increased blood pressure
  • Diarrhoea
  • Sinus headache
  • Changes in some blood tests
  • Pain in the upper abdomen
  • Headache
  • Increased pressure in the brain

Please speak to your doctor if any of these side effects bother you or do not go away.

You can find more information regarding side effects, please refer to our "side effects" tab where you will find information on more serious side effects.

Efracea Dosage and Directions

How to take Efracea

Our pharmacist and prescribers follow NICE prescribing guidelines when prescribing Efracea modified release capsules.

Always take Efracea exactly as instructed by your doctor. Read the patient information leaflet thoroughly and speak to your doctor or pharmacist if you are not sure.

If you take more than you are supposed to

Taking an overdose of Efracea may cause damage to your kidney, pancreas or liver. You should speak to your doctor or call 111 straight away if you take too much of this medicine.

If you forget to take it

If you accidentally miss a dose of Efracea, do not take a double dose to try and make up for missing a previous one.

Efracea side effects

Like all prescription and non-prescription medicines, Efracea comes with the risk of certain side effects, although not everyone who takes it will get them.

Serious Side Effects

Rarer side effects of Efracia will only affect between 1 and 10 people in every 10,000 who use it. However, they may include:

  • Allergic reaction throughout your body
  • Skin rash or hives
  • Changes in the number of certain types of blood cells
  • Liver damage
  • Increased level of urea in your blood
  • Inflammation of the membrane which surrounds the heart
  • Increased pressure in the brain
  • Dry mouth
  • Nausea, vomiting, anorexia or diarrhoea
  • Abnormal skin reactions when exposed to sunlight

Below is a list of reactions which are extremely rare, affecting less than 1 in every 10,000 users of Efracea:

  • Haemolytic anaemia (damage to your red blood cells)
  • Brown-black discolouration of the thyroid tissue (this is microscopic and has been reported in people who use Efracea for long periods of time. The thyroid function will remain normal)
  • Difficulty swallowing
  • Inflammation of the skin, which may cause it to flake
  • Inflammation of the intestine
  • Inflammation of the gullet
  • Ulceration of the gullet
  • Increased pressure in infants' brains
  • Worsening of systemic lupus erythematosus (SLE), which is a disease of the immune system
  • Inflammation of the tongue

The following side effect may happen at an unknown frequency:

  • Loosening of the nail from nail bed after being exposed to the sun

Speak to your doctor immediately if you suffer any of the reactions listed here.

Severe allergic reaction

In rare cases, it is possible to suffer a severe allergic reaction to Efracea.

You must dial 999 or go to A&E straight away if you get any of the following symptoms:

  • You are finding it difficult to breathe or speak
  • You have swelling in your face, mouth, throat, lips or tongue
  • You have a skin rash that may have red, itchy, swollen, blistered or peeling skin
  • You have tightness in your chest or throat
  • You are wheezing

You may be having a severe allergic reaction and require immediate treatment in hospital.

These lists may not be exhaustive. Always read the patient information leaflet for comprehensive details on side effects.

If you are worried about getting side effects from this treatment, please do not hesitate to speak to your doctor or pharmacist about your concerns.

Efracea Warnings and Drug Interactions

Certain other medicines may interact with Efracea. Before using this treatment, make sure that you inform your doctor if you are currently taking (or have recently taken) any other form of medication. This includes both prescription and non-prescription medication, herbal remedies, vitamins and supplements.

Efracea may make certain antibiotics less effective, including penicillin.

Do not take any antacids or multivitamins, or any products containing any of the following for at least 2 to 3 hours after taking Efracea. These may reduce its effectiveness if you take them at the same time:

  • Any products containing calcium (milk, dairy products, fruit juices which contain calcium)
  • Aluminium
  • Magnesium (such as quinapril tablets for high blood pressure)
  • Iron or bismuth
  • Cholestyramine
  • Activated charcoal or sucralfate

Do not take Efracea alongside isotretinoin (a prescription treatment for severe acne); this may risk increased pressure in the brain.

If you are taking any blood thinners, your doctor may need to adjust your dose.

If you are taking any diabetes treatments, your doctor may also need to adjust your dose.

Do not use any treatments for heartburn or ulcers for at least 2 hours after using Efracea.

Taking barbiturates, such as painkillers or sleeping pills, may reduce how long Efracea stays in your system. Inform your doctor if you are taking:

  • Primidone
  • Cyclosporin
  • Carbamazepine
  • Rifampicin
  • Diphenylhydantoin
  • Phenytoin

There is a risk of serious damage to the kidneys if Efracea is taken alongside the general anaesthetic methoxyfluorane.

For more information on medicines that interact with Efracea MR capsules.

These capsules contain sugar (sucrose) and allura red AC aluminium lake (E129). Do not use Efracea without speaking to your doctor if you have been told that you have an intolerance to certain sugars. Allura red AC aluminium lake (E129) may cause allergic reactions.

Efracea and food

Swallow these capsules with plenty of water to wash it down completely.

Do not swallow the capsules with milk or any dairy products; these contain calcium which can reduce Efracea's effectiveness.

Do not consume any dairy products for at least 2 to 3 hours after you have taken Efracea.

Driving and operating machinery

There is no evidence to show that Efracea will directly impair your ability to drive. Nonetheless, if you have any side effects which impair your vision or judgement, you should not drive, cycle or operate machinery until you feel better again.

Always read the patient information leaflet for full details on warnings and drug interactions. If you have any questions or concerns, we strongly advise you to discuss these with your doctor or pharmacist.

Pregnancy and breastfeeding

Efracea is not suitable for women who are breastfeeding. This medicine may cause permanent teeth discolouration in the unborn baby.

Similarly, it may also cause tooth discolouration and reduce bone growth in any babies who are being breastfed. For this reason, mothers who are breastfeeding should not use Efracea for long periods.

If you are currently breastfeeding or pregnant, are trying to get pregnant or think you might be pregnant, please make sure you speak to your doctor before using Efracea.

For more information on taking Efracea during pregnancy and breastfeeding.

Order safely

Medicine Direct is fully registered with the General Pharmaceutical Council (GPhC). This means that we can promise our customers safe and genuine medication when they order with us.

The members of our medical team are registered with the General Pharmaceutical Council (GPhC), the General Medical Council (GMC) and the MHRA. They are fully qualified to recommend treatments for medical conditions, just like your local GP. All of our doctors and pharmacists have experience in working in NHS hospitals or other professional clinical settings.

We offer a swift delivery service on all of our medical products, which are despatched from our UK-based pharmacy. Not only that, but if you order by 2pm, we can offer you next day delivery.

Efracea Ingredients

The main active ingredient within this medicine is: Doxycycline monhydrate

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Medically Reviewed byHussain Abdeh MPharm: 2211840

Updated on: 17/08/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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