Epiduo Gel

  • Treats moderate to severe acne
  • Will get to work after the first application
  • Fights against acne causing bacteria
From As low as £29.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

All-inclusive service

prescription included

Fast next day delivery

order before 2pm

UK registered pharmacy

and team of dispensers

What is Epiduo gel?

Epiduo gel is a topical medicine which contains the active ingredients adapalene and benzoyl peroxide.

It is a prescription-only medicine. You can buy Epiduo gel online from Medicine Direct after a consultation with an online doctor, who is fully certified.

Epiduo gel is available in various dosages; our online pharmacy sells the 2.5% dose, which comes in a 45g tube.

If you order with us before 2pm, we will despatch your order via Royal Mail and you will benefit from next day delivery.

What is Epiduo gel used to treat?

This lightweight gel is an effective acne treatment.

Acne is caused by the overproduction of sebum, which is produced by glands under the surface of the skin, known as sebaceous glands. Sebum is a natural, oily substance that is required to keep your skin smooth. Acne is often caused by an overproduction of sebum, which can block the skin's pores and cause them to become infected. This can result in the formation of spots, whiteheads and blackheads.

Using Epiduo gel has provided effective treatment for acne for many sufferers. The active ingredient adapalene belongs to a group of drugs called retinoids and acts specifically on the skin processes that create acne. Benzoyl peroxide is an antimicrobial agent that softens and peels the outer layering of the skin. It is an antiseptic which fights the bacteria that causes acne.

Epiduo gel is particularly useful when used to treat acne that is moderate to severe.

Who can use Epiduo gel?

Epiduo gel may not be suitable for everyone to use as an acne treatment.

Do not use Epiduo gel if any of the below apply to you:

  • You are allergic to benzoyl peroxide, adapalene or any other ingredient contained in this medicine
  • You are currently pregnant or think you might be pregnant
  • You are trying to get pregnant

It is not suitable for children who are under the age of 12 years old.

Possible side effects

Like all acne treatments, Epiduo gel can cause a risk of certain side effects, although these will not affect everyone who uses the medicine.

Around 1 in every 10 people who use Epiduo gel may experience adverse skin reactions.

Common side effects of using this medicine affect 1 in 10 people and may include:

  • Skin irritation
  • Eczema
  • Skin burning sensation

These reactions may affect 1 in every 100 people who apply Epiduo gel:

  • Dry skin
  • Rash
  • Tingling sensation or pins and needles at the application site(s)
  • Itching of the skin
  • Allergic skin reaction
  • Sunburn

You should speak to your doctor if any of these reactions bother you or do not go away. They may instruct you to reduce your dosage or to apply it less frequently.

This list is not exhaustive. Please, refer to the Side Effects tab for a list of rarer, more serious reactions you may experience while using this acne medication

Where can I buy Epiduo?

Never order medicine online unless it is from a pharmacy that is registered with the General Pharmaceutical Council and General Medical Council, like Medicine Direct.

After a consultation with an online doctor, they will prescribe you Epiduo, which will be despatched from our pharmacy in discreet packaging via Royal Mail. Order online before 2pm and our pharmacy will make sure it is delivered the very next day.

Epiduo Dosage


Always apply Epiduo gel exactly as instructed by your doctor. Read the patient information leaflet, which will accompany your medicine, thoroughly before you start to use it. Speak to your doctor or pharmacist if you are unsure how to apply Epiduo.

This medicine should not be used by anyone who is under the age of 12 years old.

Do not stop using acne treatments until you have completed the course of treatment set out by your doctor.

our pharmacists and prescribers will follow NICE guidelines when prescribing epiduo Gel.

How to apply Epiduo

As a facial acne treatment, use Epiduo gel once a day, at bedtime.

  1. Wash the affected area(s) with gentle soap and warm water, then gently dry with a towel.
  2. Apply a thin layer of Epiduo gel over the areas affected by acne spots.
  3. Wash your hands thoroughly once you have finished applying the gel.

How long will I need to use it for?

Your doctor will advise you on how long you need to use acne treatments.

If you have been using Epiduo for longer than 4 weeks and have not noticed any improvement in your acne, you should go back to your doctor to discuss whether you should continue this treatment.

They may prescribe you another medicine to purchase from the pharmacy.

What if I use more than I am supposed to?

Applying more Epiduo gel than you have been instructed to will not treat your acne any faster or more effectively.

Your skin may become irritated and/or red.

You should contact your doctor or pharmacy immediately if:

  • Your child has accidentally taken the medication
  • You have applied more Epiduo gel than you were supposed to
  • You or someone else has accidentally swallowed some of the medicine

What if I forget to apply it?

If you forget to apply it, wait until the next night and continue to apply Epiduo as normal.

Do not apply it more than once in the same 24 hour period.

Epiduo FAQ's

How long will it take Epiduo to work?

Epiduo gel's active ingredients (benzoyl peroxide and adapalene) will get to work from the first application, but it may take a few weeks for you to notice real improvements in your acne. You should speak to your doctor if you do not notice any improvement after between 4 and 8 weeks of using Epiduo gel. Other treatments may be more suitable for you to use. To effectively treat acne, it is important you are consistent with applying this treatment.

Can you buy Epiduo gel over the counter?

This medicine is only available to buy from a pharmacy when you have a prescription. You can order it online at Medicine Direct's pharmacy when you have had a consultation with a certified online doctor, who will prescribe you Epiduo gel if they deem it an appropriate treatment for your acne. We offer next day delivery via Royal Mail if you order with us before 2pm. Never order medicines online unless it is from a UK registered pharmacy like Medicine Direct.

How do I use it?

  • As a facial acne treatment, apply Epiduo gel once a day, at bedtime.
  • Wash the affected area(s) with gentle soap and warm water, then gently dry with a towel.
  • Apply a thin layer of Epiduo gel over the areas affected by acne spots.
  • Wash your hands thoroughly once you have finished applying the gel.

Are there other acne treatments?

Yes, there are many other treatments available to help with acne, many of which contain benzoyl peroxide, just like Epiduo gel. Benzoyl peroxide is an effective antiseptic which can help to kill the bacteria caused by acne. Other treatments can come in the form of creams, gels, tablets and other methods. Speak to your doctor about the various treatments available; they will be able to advise as to which ones would be suitable for you to try.

Epiduo Serious Side Effects

The more common side effects of Epiduo gel can be found on the main product page.

It is not known how likely you are to experience the following side effects of Epiduo gel, but you should speak to your doctor if you experience:

  • Burns to the affected areas you have applied the gel
  • Changes in the colour of your skin
  • Swelling of the eyelids
  • Skin pain
  • Blisters

Your doctor may instruct you to apply a lower dose of the medicine, or apply it less frequently.

In rare cases, you may suffer from a serious allergic reaction from using this medicine.

Call 999 or go to A&E straight away if you experience any of the following symptoms:

  • You are finding it difficult to speak or breathe
  • You have tightness in your chest or throat
  • You are wheezing
  • You develop a skin rash that is red, itchy, swollen, blistered or peeling skin
  • You have swelling in the mouth, face, tongue, lips or throat

You may need immediate treatment in hospital.

Always read the patient information leaflet before using Epiduo Gel.

Epiduo Warnings and drug interactions

Other medicines and treatments may interact with Epiduo gel and hinder its effectiveness, or increase your risk of suffering from side effects.

You must always tell your doctor if you are currently taking any other medication before you start taking another one. This includes prescription and non-prescription medicines, herbal remedies, vitamins and supplements.

In particular, make sure you inform your doctor if you are currently using any of the following treatments:

  • Any other acne treatment that contains benzoyl peroxide and/or retinoids.
  • Try to avoid using this gel at the same time as any cosmetics; this could irritate, dry or exfoliate your skin

Always read the patient information leaflet thoroughly before using any benzoyl peroxide products, for a full list of drug interactions.

If you have any questions or concerns, we strongly advise you to discuss these with your doctor or pharmacy before you begin your course of treatment.

Pregnancy and breastfeeding

This medicine is not suitable for women who are pregnant. If you are currently pregnant, think you might be pregnant, or are trying to get pregnant, make sure you tell your doctor. Alternative treatments may be more suitable for you to use.

Speak to your doctor before using this medication if you are currently breastfeeding. If your doctor has told you it is safe to use, do not apply Epiduo gel to your chest area; this will stop your baby from ingesting the gel.

Epiduo Ingredients

Epiduo gel contains the active ingredients adapalene and benzoyl peroxide.

Inactive ingredients also contained in this medicine are: disodium edetate, docusate sodium, glycerol, poloxamer, propylene glycol (E1520), Simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, polysorbate 80, sorbitan oleate) and purified water.

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

This page has recently been medically reviewed by Hussain Abdeh MPharm: 2211840

Published on: 12/10/2020

Updated on: 20/05/2021

This content has been written by James Nuttall and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh.

Superintendent pharmacist Hussain Abdeh at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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