Simvastatin is commonly used to lower high cholesterol in patients as it is part of the group of drugs called ‘statins’ which work to lower the production of bad cholesterol. Simvastatin increases the liver's natural production of healthy cholesterols, in effect lowering the harmful cholesterols.


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Simvastatin used for High Cholesterol

Simvastatin is available to buy with a valid prescription as a tablet. It is commonly used to lower high cholesterol in patients as it is part of the group of drugs called ‘statins’ which work to lower the productive of bad cholesterol. By lowering the cholesterol in your blood, your liver is able to more easily absorb your cholesterol which in turn lowers cholesterol levels in your blood. Simvastatin is also able to prevent the production of dangerous fats which are often found in your blood such as triglycerides, as well as produce good forms of cholesterol.

It is also effective in averting heart diseases, attack and strokes. This means it is safe to continue taking even when you feel better as you will still be benefitting from its reduction of high cholesterol. Overall, Simvastatin is considered a very safe medicine, with very little and rarely reported side effects.

Simvastatin Dosage

Here at Medicine Direct we sell the three most commonly prescribed strengths of 20, 40 and 80g. They are orally administered in the form of tablets. It is safe to be taken by both adults and children aged 10 and above.

Please note the maximum dose prescribed to children is 40mg. Your doctor will decide on which strength of dose to prescribe you in accordance and review of your symptoms and levels of cholesterol, as well as considering other medications you may be taking.

Simvastatin 20mg

This is the lowest strength of Simvastatin we sell. This is commonly prescribed for children or those with slightly higher than normal cholesterol.

Simvastatin 40mg

40mg is the maximum strength dose of Simvastatin suitable for children. This is the most commonly prescribed form for treating high cholesterol to be taken once daily. It is given to patients with diabetes, peripheral vascular disease, a history of stroke, a high risk of a CHD event or other cerebrovascular diseases.

Simvastatin 80mg

This is the strongest dose of Simvastatin possible to be prescribed for more serious cases of high cholesterol and related diseases, and is usually prescribed if you have not reached the desired levels of cholesterol on lower strengths of the medicine. Your doctor will have to review your symptoms before prescribing this strength of Simvastatin as it can increase the risk of myopathy

Simvastatin is not suitable for everyone. Please inform your doctor before taking it if you relate to anything on the list below:

  • Know you have had an allergic reaction to this or any other medicine before
  • Suffer from liver or kidney complications or problems
  • Trying to conceive a baby, may be pregnant, are pregnant or if you are breastfeeding
  • Severe lung disease
  • Drink big quantities of alcohol
  • Suffer from an underactive thyroid
  • Have a muscle disorder

Simvastatin recommended daily dose and how to take

It is generally recommended by doctors for patients to take Simvastatin in the evening once a day with a glass of water. One of the benefits of the medicine is that it does not effect the stomach, so it is safe to take before or after eating.

The usual prescription for this medicine is between 10-40mg once a day. However, those that suffer from very high cholesterol may be advised to take a higher dose of 80mg once a day.

Do not open or chew the tablets, they must be swallowed whole. They are also most effective when following other health diet choices such as getting regular exercise, managing your stress and stopping smoking.

Never double up on doses if you have forgotten a previous dose.

Below are the general recommendations of dosages made by doctors in accordance to disease:

  • Hypercholesterolaemia

The usual dose for this condition is one 10-20mg Simvastatin tablet taken per day alongside an increase in exercise. If a patient requires a larger decrease of cholesterol in their blood they may be prescribed to start on a 20-40mg single dose per day.

  • Homozygous familial hypercholesterolaemia

The general recommended administration of Simvastatin for this condition is one dose of the Simvastatin 40mg tablet per day in the evening.

  • Cardiovascular Prevention

Usually doctors will recommend patients between 20-40mg of Simvastatin to be taken once a day in the evening. This is usually followed by guidance on an increase of exercise and a change in diet.

Simvastatin Side Effects

Simvastatin is known to rarely present side effects. Nonetheless, please talk to your pharmacist or doctor if you experience any of the following:


  • Muscle/ joint ache
  • Diarrhoea
  • Feeling sickly or nauseous
  • Constipation
  • Dizziness or light headed
  • Headache
  • Increase in production of gas


  • Muscle feeling painful, tender or cramping. This can be signs of your muscles breaking down and/ or kidney damage.
  • A yellowing of the skin and eyes can be a sign that your liver is suffering from problems
  • A pink-red blotchy rash on your palms or the soles of your feet
  • A tight chest, feeling a shortness of breath, a cough or unintentional weight loss – this can be a sign of lung disease

In rare cases patients taking Simvastatin can suffer from a severe allergic reaction to the medicine. If you experience any of the warning symptoms you MUST contact an emergency service such as 111 or 999 immediately. The signs of a severe allergic reaction are:

  • Developing a skin rash which is itchy, red, swollen, blistered or peeling
  • Your chest or throat feeling tight. This can also be displayed through wheezing.
  • Experiencing difficulty in breathing or talking
  • Your facial extremities become swollen i.e. you mouth, face, lips, tongue or throat.

How can I buy Simvastatin online in the UK?

If you are a valid UK citizen and have a prescription from a doctor, you will be able to purchase Simvastatin 20mg, 40mg or 80mg online in the UK with us, Medicine Direct.

Can you take Simvastatin if you are breastfeeding or pregnant?

It is not recommended to take Simvastatin whilst breastfeeding or during pregnancy. Moreover, you must let your doctor know if you are planning on trying to conceive a child before being prescribed this medicine. If you know you have become pregnant during your course of Simvastatin, do no take any more dosages of the medicine and contact your doctor.

Although it is as of yet unknown as to whether Simvastatin can pass into breast milk, it may cause problems for a baby. This means that you will need to stop administrating Simvastatin whilst breast feeding a baby.

There is no evidence that taking Simvastatin will decrease your fertility or chances of becoming pregnant.

What happens if you eat or drink grapefruit whilst taking Simvastatin?

You must not consume grapefruit in any form whilst taking Simvastatin. This is because grapefruit increases the concentration of the medicine in your blood.

Can you drink alcohol whilst taking Simvastatin?

You are allowed to drink alcohol whilst taking your course of Simvastatin. However, if you drink in a large quantity you increase your chances of suffering from side effects. It is recommended that you do not drink more than 14 units of alcohol a week.

What happens when you stop taking Simvastatin?

Unfortunately, the positive benefits of Simvastatin will only happen during the consumption of the medicine. If you were to stop taking your advised dosage without replacing it with another cholesterol-lowering drug or treatment it is possible that your body’s level of cholesterol will begin to rise again. Please talk to your doctor before changing your dosage habits of Simvastatin. It may be possible for your doctor to recommend a different form of cholesterol lowering treatment or lowering the dosage if it is not agreeing with you.

What is the best time to take Simvastatin?

Research suggests that the best time to take Simvastatin is during the evening.

What is the drug simvastatin used to treat?

Simvastatin is commonly used to treat high levels of cholesterol or triglycerides (fats) in your blood stream. It can also be used to treat hereditary conditions which cause high blood pressure or those that are suffering from coronary heart disease, or are at the risk of developing a coronary heart disease due to diabetes. It has also been linked to increases in the production of good cholesterol.

Other Products similar to Simvastatin - Atorvastatin

Simvastatin is a medicine that’s primary use is to treat individuals suffering with a high cholesterol. There are many other statin’s that are used to treat high cholesterol. The most commonly prescribed statin is atorvastatin.

Atorvastatin is another medication that works in a very similar way to simvastatin in the way that it is consumed and helps to promote the liver’s creation of good cholesterol, effectively lowering the bad cholesterol in our body.


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