Domperidone is usually prescribed to those needing help with bowel and stomach movements. Other symptoms effectivley aided by this medication include nausea and vomiting.


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What is Domperidone?

Domperidone tablets contain domperidone as the active ingredient; this substance belongs to a group of medicines known as dopamine antagonists.

It is an anti-sickness medicine that comes as tablets or a liquid you swallow. You can only buy Domperidone 10 mg when you have a prescription.

It is available to order at Medicine Direct, following an online consultation with one of our certified doctors. If you order with us before 2pm, next day delivery is available.

What is Domperidone used to treat?

Domperidone is used as a treatment for nausea and vomiting. It can also be used to alleviate stomach pain if you are having end of life care (palliative care).

It works by blocking the messages that are passed between the brain and the digestive system.

This causes the muscles at the exit of your stomach to relax, reducing the likelihood of you being sick.

Domperidone is also able to block messages sent between parts of your brain known as the chemoreceptor trigger zone (CTZ) and the vomiting centre. This prevents nausea and vomiting.


Always use Domperidone exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly before you start your course of treatment. Speak to your doctor or pharmacist if you are not sure of how to take it.

Domperidone is for oral consumption only. Each tablet should be swallowed whole with a glass of water. Do not crush or chew the tablets.

Take Domperidone 15 to 30 minutes before you eat a meal and, if required, before you go to bed.

Adults and children over 12 years old

The usual dose is one tablet, to be taken 3 times a day, ideally before a meal.

Do not take more than 3 tablets a day.

If you have any kidney problems, your doctor may instruct you to take a lower dose or to take Domperidone less often.

How long will I need to take it?

Your nausea and vomiting symptoms will normally be resolved within 3-4 days of taking this medicine.

You should not take Domperidone tablets for longer than 7 days, unless you have been advised to do so by your doctor.

What if I forget to take it?

If you accidentally miss a dose of Domperidone, take the medication as soon as you remember, as long as it is not almost time for your next scheduled dose.

If it is almost time for your next dose, skip the missed dose and continue taking Domperidone as usual. 

Do not double dose to try and make up for a missed dose.

What if I take more than I am supposed to?

Taking too much Domperidone can be dangerous to your health.

Taking more than the prescribed dose can result in a fast or irregular heartbeat.

If you or someone else has taken too much Domperidone, you should call 111 or speak to your doctor for advice straight away.

Who can use Domperidone?

Domperidone is an effective treatment for nausea and vomiting, but it may not be suitable for everyone to use.

This medication is only recommended for adults and adolescents aged 12 years old and above.

In some cases, it is prescribed for babies and young children, but only by a specialist doctor.

You should inform your doctor if any of the following conditions apply to you before you start to use this medicine:

  • You weigh less than 35kg
  • You have ever had bleeding from your stomach or gut
  • You have ever had an allergic reaction to domperidone or any other medicine in the past
  • You have any conditions caused by a bowel obstruction, such as Crohn's disease or diverticulitis
  • You have a tumour in your pituitary gland
  • You have an irregular heartbeat
  • You have liver, kidney or heart problems
  • You have recently had abdominal surgery

Pregnancy and breastfeeding

Domperidone is not normally recommended for women who are currently pregnant.

If you are pregnant, think you might be pregnant, or are trying to get pregnant, you should speak to your doctor before you use this medicine.

Domperidone is not recommended for women who are currently breastfeeding, because it passes into the breast milk in small quantities. You should speak to your doctor for more information, as alternative medicines may be more suitable for you.

Domperidone is sometimes prescribed to increase a woman's milk supply, but research has shown that this can give your baby an irregular heartbeat. Speak to your doctor about the possible benefits and health risks associated with taking this medication while breastfeeding.

Possible side effects

Like all medicines, Domperidone comes with the risk of certain side effects, although not everyone who takes the medicine will have them.

The most common side effect of using this medication is dry mouth.

Below is a list of less common side effects you may suffer while using Domperidone. You should speak to your doctor if any of these reactions bother you or do not go away:

  • Feelings of nervousness, anxiety or agitation
  • A decreased sex drive or loss of interest in sex altogether
  • Diarrhoea
  • Rash
  • Headaches
  • Hives
  • Painful or tender breasts
  • Feeling dizzy
  • Sleepiness
  • Milk discharge from your breasts
  • Feeling weak
  • Itchiness

Please note, this list is not exhaustive. For a list of rarer and more serious adverse effects you may experience, please refer to the Side Effects tab on this page.


Can you buy Domperidone in the UK?

Yes, it is available to purchase from a pharmacy when you have a prescription from a doctor.

You can buy Domperidone at Medicine Direct's online pharmacy, following an online consultation with one of our certified doctors, who will assess your symptoms and prescribe Domperidone if they find it to be the right treatment for your condition.

Never order from anywhere other than a pharmacy that is registered with the General Pharmaceutical Council (GPC) to purchase Domperidone. UK registered pharmacies like Medicine Direct can guarantee genuine prescriptions from registered doctors, as well as genuine medicine when you order from us.

If you order with us before 2pm, we can offer you next day delivery.

Does Domperidone interact with any other drugs?

It may interact with other medicines when taken at the same time. It may also interact with vitamins, supplements and herbal remedies.

Please, refer to the Warnings and Drug Interactions tab for full details.

How do you take Domperidone?

Always follow your doctor's instructions when taking a prescription medicine. If you have any questions, speak to them for more information.

Domperidone should be swallowed whole with a drink of water.

Adults and children over 12 years old should take one tablet 3 times a day, ideally before a meal.

Do not take more than 3 tablets a day.

People who have kidney problems may be told to use a lesser dose.

You should find your symptoms improve after 3-4 days. Do not keep taking the medicine for longer than 7 days.

Side Effects

Below is a list of side effects which can occur when you use this medication. It is not known how frequently these reactions may occur.

Speak to your doctor if you find you suffer from any of the following:

  • Enlarged breasts in men
  • Upward movement of the eyes
  • You are unable to urinate
  • There are changes in certain laboratory test results
  • A stop in menstrual periods in women
  • Restless legs syndrome
  • Depression

Serious allergic reaction

In some cases, patients may find that they suffer from a serious allergic reaction after they have used this medicine.

You should call 999 or go to A&E straight away if you have any of the following symptoms:

  • You are wheezing
  • You have swelling in your mouth, lips, tongue, face or throat
  • You are finding it hard to speak or breathe
  • You have tightness in your chest or throat
  • You have a skin rash that is red, blistered, swollen, itching or peeling skin

You might require immediate treatment in hospital.


The active substance in this medication is domperidone.

Inactive ingredients also contained are: microcrystalline cellulose, lactose monohydrate, maize starch, povidone K30, sodium lauryl sulphate, silica colloidal anhydrous, magnesium stearate.

Warnings and drug interactions

Domperidone can interact with certain drugs when used at the same time, which can hinder its effectiveness and also increase your risk of side effects.

You should also inform your doctor if you are currently using, or have recently used, any other medicines. This includes both prescription and non-prescription medication, herbal remedies, vitamins and supplements.

In particular your doctor should be made aware if you are currently taking:

  • Medicines for cancer, or if you are having treatment for cancer
  • Any medicines used to treat the HIV infection
  • Medicines to treat malaria
  • Antidepressants or antipsychotic medicines
  • Medicines to treat any heart conditions or high blood pressure
  • Any antibiotics or medicines for fungal infections

You should only use one anti-sickness treatment at any one time. If Domperidone does not work for you after a few days, you should speak to your doctor, who will recommend other treatments available for you.

Never order medication online unless it is from a UK pharmacy that is registered with the General Pharmaceutical Council, like Medicine Direct.

All of our doctors are registered with the General Medical Council (GMC), and if you order with us before 2pm, next day delivery is available.

Order with us today, to begin your treatment immediately.

Please tell your pharmacist or Doctor if you are taking any other forms of medications, either prescription or over the counter medicines. This also includes any vitamins or supplements.

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