Prochlorperazine 5mg Tablets

  • Treats nausea and sickness
  • Works within 30-60 minutes
  • Effectively treats nausea caused by a range of conditions 

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Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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What is Prochlorperazine?

Maximum quantity per treatment - 84 tablets

Prochlorperazine is an anti-sickness medicine that is taken to prevent nausea and vomiting. It contains the active ingredient prochlorperazine maleate and can be taken to treat the likes of morning sickness and vertigo.

Prochlorperazine is also available as a branded version, Stemetil 5mg tablets which can be bought online at Medicine Direct.

Prochlorperazine can be used by adults and children over 1 year of age and will normally start to work after around 30 minutes of being taken.

What are Prochlorperazine 5mg tablets used to treat?

Prochlorperazine 5mg tablets are an effective medicine for nausea and vomiting. They can also be used to treat migraines and dizziness as a result of ear problems. In some cases, Prochlorperazine may be prescribed to treat anxiety.

You can use Prochlorperazine 5mg tablets to treat nausea that comes with a variety of different conditions, including:

  • Morning sickness
  • Travel sickness
  • Migraines
  • Vertigo (dizziness)
  • Conditions that affect balance
  • Sickness that comes from cancer treatments, general anaesthetics or from taking other medicines

For more information on what prochlorperazine is used to treat, read our helpful medical guide.

How does Prochlorperazine work?

The active ingredient contained in Prochlorperazine 5mg tablets is prochlorperazine maleate, which belongs to a group of medicines known as phenothiazines.

Typically, Prochlorperazine 5mg tablets will start to work in around 30 to 60 minutes. They work by blocking the dopamine receptors in the section of the brain that causes nausea. This stops messages being sent to the “vomiting centre” in the brain, relieving the feeling of nausea.

Prochlorperazine dose

The average starting dose for adults is as follows:


Starting dose


5mg three times a day

Stop nausea or vomiting

5mg or 10mg two or three times a day

Treatment of nausea or vomiting

20mg, which may be followed by 10mg two hours later

Short-term anxiety treatment

15-20mg a day in divided doses


The doses above may be altered as treatment progresses, but you should always follow your doctor’s dosage instructions.

These doses may be lower to treat elderly patients.

If Prochlorperazine is prescribed to treat children, their dose will be decided upon by their doctor in accordance with their weight.

How to take Prochlorperazine

Swallow Prochlorperazine tablets whole with a drink of water.

Do not let the tablets touch your skin for very long; this may cause itching, redness or swelling.

Read the patient information leaflet before you start to take this medicine for full instructions. Always follow your doctor’s instructions.

Who can take Prochlorperazine tablets?

Prochlorperazine provides effective relief from nausea and vomiting, but it may not be suitable for everyone to use.

Do not take Prochlorperazine tablets if any of the following apply to you:

  • You are allergic to prochlorperazine maleate or any of the other ingredients contained in this medicine
  • You have any prostate gland problems
  • You have any liver problems
  • You have any blood problems
  • You have epilepsy, Parkinson’s disease or glaucoma

Talk to your doctor before taking Prochlorperazine tablets:

  • If you are elderly
  • If you are currently pregnant, trying to get pregnant, think you might be pregnant or are breastfeeding
  • If you have AIDS
  • If you suffer from myasthenia gravis, a condition which causes muscle weakness
  • If you are at risk of a stroke or blood clot, such as diabetes, high cholesterol levels, high blood pressure or you smoke
  • If you or anyone in your family has a history of blood clots

Pregnant women should only take Prochlorperazine if their doctor recommends it. Make sure your doctor is aware that you are pregnant.  

When taken in the final three months of pregnancy, a newborn baby may experience the following:

  • Muscle stiffness/weakness
  • Agitation
  • Difficulty feeding
  • Breathing problems
  • Shaking

Speak to your doctor if your baby develops any of these issues.

You should not take these tablets while breastfeeding as there is not enough research to prove that it is safe to do so. Learn more about prochlorperazine during pregnancy.

This list may not be exhaustive. Refer to the patient information leaflet for a full list of warnings.

Prochlorperazine Side Effects

Common side effects include:

  • Dry mouth
  • Headache
  • Stuffy nose
  • Blurred vision
  • Sleepiness or drowsiness

Please note this list is not exhaustive, for more information on side effects please read our detailed medical guide on Prochlorperazine side effects.

Can you buy Prochlorperazine over the counter?

You can buy Prochlorperazine over the counter for nausea and vomiting. However, you must have been diagnosed with migraines to be able to do this, otherwise you will need to be prescribed Prochlorperazine by a doctor.

Can you buy Prochlorperazine online in the UK?

You can buy Prochlorperazine 5mg tablets online from Medicine Direct once you have completed a simple online consultation with a registered medical professional. This will require you to fill out a confidential questionnaire, which will be reviewed by a prescriber to ensure that Prochlorperazine is the most suitable treatment for your condition.

You can then place your order with our UK-based pharmacy; order by 2pm and you will receive next day delivery.

For your own safety, do not order any medication online from anywhere other than regulated UK pharmacies, like Medicine Direct.

Prochlorperazine alternatives

Prochlorperazine is available as Prochlorperazine Buccal tablets which dissolve in your mouth, making them an excellent choice for people who have difficulty swallowing medication. They are also available as a branded version, Stemetil (Prochlorperazine) 5mg Tablets.

Other medicines which work in a similar way include Domperidone and Cyclizine 50mg tablets. People respond differently to anti-sickness medicines depending on their condition and symptoms, so you may need to try more than one treatment until you find a fully effective one.

Prochlorperazine 5mg tablets Dosage and Directions

How to take Prochlorperazine tablets

Our pharmacists and prescribers will follow NICE prescribing guidelines when prescribing Prochlorperazine tablets. 

Always take Prochlorperazine tablets exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly and ask your doctor or pharmacist if you are not sure.

If you take more than you were supposed to

An overdose of Prochlorperazine can be dangerous. Call 111 or speak to your doctor straight away if you have taken too much.

How to store Prochlorperazine Tablets

Store this medicine out of the sight and reach of children.

Keep out of direct sunlight; store the tablets in the original carton.

These tablets do not require any special storage conditions, but do not continue to use the medicine after the expiry date, which can be found on the packaging. The expiry date refers to the last day of the month stated.

Can I take Prochlorperazine for a long time?

You can take Prochlorperazine in the long term if required, but this should only be on the advice of your doctor.

Is Prochlorperazine a sedative?

Prochlorperazine is not a sedative, although it does possess sedative properties. You will normally develop a tolerance to the sedation effects quickly.

Can I drink alcohol with it?

Drinking alcohol may make possible side effects worse, so it is advisable to avoid drinking alcohol while taking Prochlorperazine.

How safe is Prochlorperazine?

Prochlorperazine is generally considered to be a safe medicine. However, it can cause side effects such as blurred vision and dizziness. You should not stand up quickly or drive until you know how this medicine affects you. Prochlorperazine may also make you more vulnerable to sunburn.

Will Prochlorperazine work straight away?

This medicine will normally get to work after between 30 to 60 minutes of being taken.

Can I take paracetamol with Prochlorperazine?

You can take non-prescription painkillers such as paracetamol or ibuprofen while taking Prochlorperazine. However, you should not take any painkillers that contain codeine, dihydrocodeine or co-codamol at the same time as Prochlorperazine as this may cause drowsiness.

Is Prochlorperazine used for anxiety?

Prochlorperazine can be used to treat nervous, mental or emotional conditions. It can also be prescribed for non-psychotic anxiety.

Is Prochlorperazine addictive?

Prochlorperazine is not normally addictive. However, you may suffer withdrawal symptoms if you stop taking it suddenly after taking it in the long term. If you wish to stop taking Prochlorperazine after a prolonged period of use, speak to your doctor about reducing your dose gradually. Do not stop taking it suddenly.

Are there other anti-sickness medicines?

Yes, a number of anti-sickness medicines are on the market, some of which are available over the counter, while some require a prescription.

Prochlorperazine 5mg Tablets Side Effects

Rare side effects of Prochlorperazine include:

  • Jaundice
  • Blood problems
  • Breast swelling (in men and women)
  • Milk secretion from the breast which is not a result of breastfeeding
  • Feeling anxious or restless
  • Women not getting their monthly period

Contact your doctor right away if you suffer from any of the below:

  • Convulsions
  • Symptoms of an infection (shivering, high temperature, sweating, headache, swollen glands or sore throat)
  • Blood clots
  • Symptoms of decreased sodium concentration in the blood (headache, nausea and vomiting, cramps, seizures, coma)
  • Symptoms of a serious allergic reaction (please see below)
  • Symptoms of neuroleptic malignant syndrome (pale complexion, high temperature, alertness levels change, muscle stiffness)

Serious allergic reaction

If you notice any of the following symptoms, you must call 999 or go to A&E straight away.

You might be having a serious allergic reaction and need immediate treatment in hospital if:

  • You have swelling in your mouth, face, lips, tongue or throat
  • You are wheezing
  • You are finding it difficult to breathe or speak
  • You have tightness in your throat or chest
  • You develop a skin rash that may include red, itchy, swollen, blistered or peeling skin

Always read the patient information leaflet for full details on side effects and how you should deal with them. If you are worried about getting side effects or have any questions, we strongly advise you to discuss your concerns with your doctor or pharmacist before you start taking Prochlorperazine.

Prochlorperazine tablets Warnings and Drug Interactions

Avoid exposure to direct sunlight and use sunscreen while taking Prochlorperazine, as this medicine may make you more sensitive to sunlight.

Read the patient information leaflet for a full list of warnings and drug interactions before you start taking this medicine. If you have any questions or concerns, please speak to your doctor or pharmacist.

Other medicines and Prochlorperazine tablets

Before you start to take Prochlorperazine buccal tablets, please inform your doctor or pharmacist of any other medicines you are already using. This includes both prescription and non-prescription medicine, herbal remedies, vitamins and supplements.

It is particularly important that they are aware if you are currently taking, or have recently taken, any of the following medications:

  • Desferrioxamine (for high levels of iron in the body)
  • Lithium (for mania and depression)
  • Any sedatives or tranquilisers to help you to sleep
  • Any antihypertensive medicines for high blood pressure
  • Any anticholinergic medicines (normally used for depression)
  • Any anticonvulsant medicines (to treat or prevent fits)

For more information on medicines that interact with Prochlorperazine tablets.

Prochlorperazine Tablets with food and drink

Ideally, you should take Prochlorperazine after a meal.

Do not drink alcohol while using Prochlorperazine as it may interact with this medicine.

Driving and using machines

Prochlorperazine 5mg tablets may cause side effects like dizziness, drowsiness and convulsions.

Do not drive, cycle or operate any machinery if you experience any of these reactions while taking this medication. If these symptoms continue, please contact your doctor or pharmacist for advice.

Prochlorperazine tablets contain sucrose

Speak to your doctor or pharmacist before using this medication if your doctor has previously told you that you are intolerant to certain sugars.

Prochlorperazine Tablets Ingredients

The main active ingredient within this medicine is: Prochlorperazine maleate

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Written byHussain Abdeh MPharm: 2211840

Updated on: 11/08/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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