• Belongs to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors
  • Typically prescribed to treat High Blood Pressure 
  • Can also help prevent future heart attacks and strokes

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What is Lisinopril?

Lisinopril belongs to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors.

ACE inhibitors are used in the treatment and management of hypertension (high blood pressure), they also massively reduce the risk of heart failure, stroke and a number of cardiovascular conditions.

ACE inhibitors are one of 4 drug classes used to treat hypertension, the other 2 being Calcium Channel Blockers, Thiazide Diuretics and Angiotensin Receptor Blockers.

Lisinopril is available in several doses such as 5mg, 10mg and 20mg, depending upon the proportions of active ingredients in them.

The most common form of medication is as a tablet, but if you have difficulty in swallowing, Lisinopril is also available as a liquid medicine.

What is Lisinopril used to treat?

Lisinopril tablets are among the most common forms of high blood pressure treatments available in the UK. They are also a common prescription for people who are recovering from a heart attack; additionally, they are prescribed for heart failure and can prevent future heart attacks and strokes.

Another benefit of Lisinoprl is they delay the progression of renal disease in patients with diabetic kidney disease.

An ACE inhibitor, Lisinopril works by relaxing the blood vessels, allowing blood to pass through the body more freely, reducing the pressure on the heart. 

How do Lisinopril tablets work?

Lisinopril works by inhibiting the Angiotensin-Converting Enzyme (ACE) which is responsible for producing natural hormones that help to control blood pressure.

This hormone can also cause blood vessels to restrict and become more narrow, as a result, blood pressure is increased due to the added resistance that the heart faces when pumping blood around the body.

By inhibiting Angiotensin-Converting Enzymes, the hormone responsible for narrowing blood vessels is suppressed which allows blood vessels to widen and blood to flow thorughout the body more freely. The pressure on the heart is also reduced due to the increased blood flow.

How to take Lisinopril tablets

Lisinopril tablets can be taken with or without food, this medicine does not upset the stomach.

You should always take Lisinopril with a glass of water to help with swallowing the tablet.

It is recommended taking Lisinopril tablets at a similar time every day.

Your doctor will usually instruct you to take Lisinopril tablets once a day. They may suggest taking Lisinopril before bed the first time you take it; a common side effect of this medicine is dizziness, so it is best if you lie down after taking it for the first time.

Lisinopril Dose

The usual starting dose for Lisinopril is between 2.5mg and 10mg, once a day.

As your treatment progresses, your doctor will usually raise your dose; how much it is raised by will depend on the condition you are being treated for.

For high blood pressure, you will usually be instructed to take 20mg each day.

To decide the appropriate dose for you, your doctor will check your blood pressure and ask about any side effects you may be getting from the medicine.

It may take up to four weeks for you to feel the full effects of this medicine. Do not stop taking it unless instructed to by your doctor, Lisinopril is most effective when taken consistently and over a long period of time.

If you are taking this medicine to lower your blood pressure, it is highly likely that you will need to take it for the rest of your life.

Who can take Lisinopril tablets?

This medicine can be taken by adults and children who are at least six years old.

Lisinopril is one of the most commonly prescribed medicines to treat high blood pressure, but it may not be suitable for everyone.

You should check your blood sugar (glucose) more regularly if you have diabetes as Lisinopril can lower your blood sugar levels.

Ensure you tell your doctor if any of these apply to you:

  • You are on a low-salt diet
  • You are currently pregnant, are trying to get pregnant or think you might be pregnant
  • You are breastfeeding
  • You have any blood problems
  • You have had an allergic reaction to Lisinopril or any other medicine in the past
  • You have unstable or a low blood pressure reading
  • You have recently had diarrhoea or vomiting
  • You have heart, liver or kidney problems
  • You are going to have any surgery that requires a general anaesthetic
  • You are due to undergo desensitisation treatment to lower your allergy to insect stings
  • You have diabetes

If you have any concerns at all about taking this medicine for high blood pressure or any other conditions, you should speak to your doctor before you start to take it.

Lisinopril side effects

As is the case with all medicines, taking Lisinopril comes with the risk of certain adverse effects.

The side effects of this medicine are generally very mild, and most people will not experience any at all.

However, you should speak to your doctor or pharmacist if any of these symptoms concern you or don't go away:

  • Blurred vision
  • Headaches
  • Diarrhoea or vomiting
  • A dry, tickly cough that won't go away
  • Feeling dizzy or lightheaded, particularly when you stand up
  • Itching or a mild skin rash

Please note, this list is not exhaustive. For a list of more serious adverse reactions, please refer to the Side Effects tab on this page.

ACE inhibitor induced cough

ACE Inhibitors have been known to cause a dry and consistent cough in patients. The cough usually develops within one week of starting treatment and can last for up to six months. The cough will tend to subside after 1 to 4 days of stopping treatment.

Long term side effects of lisinopril

Lisinopril is a long term treatment, if you have been prescribed Lisinopril to treat high blood pressure, it is likely you will require this treatment for the rest of your life.

Lisinopril is not linked to any common long term side effects, however; with long term use of Lisinopril, your doctor will regularly monitor your kidney function via regular blood tests.

Can I buy Lisinopril Online?

Yes, you can buy lisinopril online form most UK online pharmacies such as Medicine Direct. You will need to complete an online healthcare questionnaire so a qualified healthcare professional can assess your condition to ensure this treatment is best suited to your condition.

When buying medicine online, it is important to ensure you are doing so from a fully regulated UK pharmacy. To learn more about the licenses we hold, our team, our medical professionals and our company as a whole, visit our about us page.

Lisinopril Dosage and Directions

Our pharmacists and prescribers follow NICE guidelines when prescribing Lisinopril.

Always read the patient information leaflet thoroughly before taking high blood pressure tablets.

Do not take any dose other than how much your doctor instructs you to take.

What if I take more than I am supposed to?

If you accidentally take too much Lisinopril, you should go to A&E or contact your doctor straight away.

Overdosing on Lisinopril may cause dizziness, a pounding heartbeat and/or sleepiness.

What if I forget to take it?

If you forget to take Lisinopril, just take it as soon as you remember.

If you do not remember until the next day, you should just skip the missed dose and continue taking the tablets as usual.

You should never double dose a medicine to make up for a missed dose.

To ensure you do not forget to take Lisinopril, it helps if you take the tablets at the same time every day, to get into a routine of taking them. Some people also find it beneficial to set an alarm to remind them.

Lisinopril FAQ's

What is Lisinopril prescribed for?

Lisinopril is an ACE inhibitor used to treat high blood pressure by relaxing and widening the blood vessels. It also provides protection against suffering future heart attacks and strokes.

How long does it take for Lisinopril to lower my blood pressure?

You should notice a reduction in your blood pressure 2 to 3 weeks after starting your treatment course.

How long will I need to take Lisinopril for?

It is likely that you will need to take Lisinopril for the rest of your life. Lisinopril is a long term treatment plan for high blood pressure.

Is Lisinopril safe to take for a long time?

Lisinopril is intended for long term use, it works better when used as part of a long term treatment plan for high blood pressure. Your doctor will continue to monitor your blood pressure and kidneys to throughout your treatment to ensure everything is working as it should. There are no long lasting side effects of Lisinopril, it is considered to be a safe drug when used long term.

Can I stop taking Lisinopril if my blood pressure has gone back to normal?

If you require medicine to lower your blood pressure, stopping your treatment is likely to cause it rise again. You should not stop taking Lisinopril without speaking to your doctor first.

Does Lisinopril cause a cough?

ACE inhibitors have been known to cause a dry and consistent cough in patients. The cough usually develops within one week of starting your treatment. In some cases it can last up to 6 months. 

Is Lisinopril a blood thinner?

No, Lisinopril is not a blood thinner and instead lowers blood pressure by relaxing and widening the blood vessels.

When should I take my tablets?

You can take Lisinopril at any time of day, however for your first few doses it is recommended taking them before bedtime as it can make you dizzy. Generally, you can take Lisinopril tablets at any time of day as long as you consistently take them at the same time every day.

Can I drink alcohol whilst taking Lisinopril?

Yes, there are no harmful interactions between Lisinopril and alcohol. It is recommended to only consume alcohol in moderation when taking high blood pressure medicine.

What is the price of Lisinopril in the UK?

Prices start from £12.99 for 28 tablets.

Lisinopril Serious Side Effects

The more common side effects of this medication can be found on the main product page.

It is unlikely this medicine will have an adverse effect on you, and most reactions are mild and do not last for long.

However, in rare cases you may experience more severe side effects. You should call the doctor immediately if you suffer from any of these:

  • Weak arms and legs or difficulty in speaking
  • Severe stomach pain
  • Yellowing skin or the whites of the eyes turn yellow - could be liver problems
  • You go pale, feel tired, faint or dizzy
  • Any sign of bleeding
  • A sore throat, fever or getting infections more easily
  • Shortness of breath, tightness in the chest or wheezing
  • Swollen ankles, blood in your urine or you are not urinating at all - could be kidney problems
  • Chest pain, a faster heart rate or tightness in the chest - could be heart problems

If you suspect you or someone with you is having a stroke, you should call 999 immediately.

In rare instances, you can have a serious allergic reaction to this medication. You should call 999 or go to A&E immediately if you experience any of the following:

  • Swelling of the tongue, face, mouth, throat or lips
  • You are wheezing
  • You have tightness in the chest or throat
  • You are finding it difficult to breathe or speak
  • You get a skin rash that is red, itchy, blistering, peeling or swollen

Always read the patient information leaflet that accompainies your medication for information on side effects.

Lisinopril Warnings and Drug Interactions

Certain medicines may interfere with how effective Lisinopril is at treating high blood pressure and other conditions.

You should inform your doctor if you are already taking any of these:

  • Steroid medicines
  • Allopurinol

Tablets to make you urinate more (diuretics) known as water pills such as Bendroflumethiazide

  • Any medicines that are used to treat heart failure, low blood pressure, asthma or allergies
  • Anti-inflammatory medicines used in the treatment of different typres of arthritis, such as ibuprofen and naproxen
  • Medicines to treat diabetes
  • Lithium (for mental health problems)
  • Racecadotril
  • Medicines to damp down your immune system
  • Medicines that can increase the level of potassium in your blood
  • Any medicines that can lower your blood pressure, including antidepressants, nitrates or medicines for an enlarged prostate
  • Procainamide
  • Medicines to treat high blood pressure

This list may not be exhaustive; you should always inform your doctor of any and all medicines you are already taking, before you start to use Lisinopril. This includes prescription and non-prescription medicines, vitamins, supplements and herbal remedies.

For more information on Drug Interactions when taking Lisinopril.

Some of the common side effects of taking this medicine include dizziness, feeling tired and blurred vision. Not everyone will experience these symptoms, but if you do you should not drive, cycle or operate machinery until you feel better again.

Pregnancy and breastfeeding

Lisinopril is not indicated for use during pregancy an is only prescribed during breastfeeding if the benefits outweigh the risks. Always speak to your doctor or pharmacsit before taking any medication if you are pregnant or breastfeeding. 

Read more about taking Lisinopril when pregnant or breastfeeding


Lisinopril Ingredients

The main active ingredient within this medicine is: Lisinopril dihydrate

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

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This page has recently been medically reviewed by Hussain Abdeh MPharm: 2211840

Updated on: 20/05/2021

This content has been written by James Nuttall and has been medically reviewed by our Superintendent Pharmacist Hussain Abdeh.

Superintendent pharmacist Hussain Abdeh at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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