Amlodipine Tablets (5mg & 10mg)

  • Highly effective in treating high blood pressure
  • Relaxes the blood vessels and allows blood to flow through more freely
  • Can lower the risk of suffering a heart attack, stroke or developing heart disease

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From As low as £12.99

Disclaimer: The prices displayed should only be used as a reference of our prices for this medicine. If you are approved for treatment, our prescribers will decide on a suitable treatment for you to jointly consider.

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High Blood Pressure Key Facts UK

  • High blood pressure is responsible for more than half of all stroke and heart attacks in the UK
  • 1 in 3 adults in the UK has high blood pressure (31% men and 26% women)
  • High blood pressure rarely has symptoms and is called the 'Silent Killer'
  • High blood pressure costs the NHS over £2.1 billion every year
  • 75,000 people died of High Blood Pressure in 2015

Source -

What are Amlodipine tablets?

Amlodipine is a calcium channel blocker that is primarily used in the treatment of high blood pressure.

Amlodipine has been used to treat high blood pressure and other complications since 1990 and is featured on the World Health Organisation's List of Essential Medicines.

Amlodipine is a prescription only medicine (POM) and is available in tablet form. It is available to buy in 5mg and 10mg doses

What is Amlodipine used for?

Amlodipine is a first line treatment option for high blood pressure. it is also widely used to treat chronic stable angina, and to prevent future heart disease, heart attacks and strokes.

Amlodipine helps to lower blood pressure by widening the blood vessels. As a result, blood is able to flow around the body easier, which also reduces the workload and pressure on the heart. By easing the pressure on the heart, amlodipine also reduces the risk of future heart attacks, strokes and developing heart disease. 

How does Amlodipine treat high blood pressure?

Amlodipine works by inhibiting the ion channels within the cells of the heart and blood vessels from absorbing calcium. Blood vessels need calcium in order to restrict and contract, this forces the heart to work harder when pumping the blood around the body and as a result increases blood pressure.

Amlodipine's inhibitory effect on ion channels prevents excessive constrictions in the coronary arteries and reduces peripheral vascular resistance, which is the resistance that must be overcome in order to pump blood around the circulatory system in the body.

Calcium channel blockers along with other high blood pressure medicines such as beta-blockers, Thiazide Diuretics, ACE-inhibitors are known to reduce Peripheral vascular resistance.

Amlodipine reduces contractions and relaxes the muscles within the blood vessels, this results in the widening of the blood vessels (vasodilation) which allows blood to flow through the body using less force from the heart.

Who can take Amlodipine?

Amlodipine is a prescription-only medicine. It can be prescribed to adults and children who are aged 6 years and over.

You should not take Amlodipine if you are trying to get pregnant or are already pregnant. If you suffer from kidney or liver problems, you should talk to your doctor before being prescribed the medication.

You should avoid eating grapefruit products and drinking grapefruit juice while taking your course of Amlodipine as it can increase the concentration of the medicine in your blood, increasing the risk of you suffering worse side effects.

Check with your doctor if this medicine is safe for you if any of the below apply:

  • You have liver or kidney disease
  • You have had an allergic reaction to Amlodipine or any other medicines in the past
  • You are trying to get pregnant or are breastfeeding

Amlodipine Dose

The dose of Amlodipine you are prescribed will be heavily dependent on your condition, diagnosis, and the severity of your blood pressure.

Typically, the initial starting dose for Amlodipine is:



Prophylaxis of Angina 5mg once daily
Hypertension 5mg once daily
Source NICE

Amlodipine has a very long half life of 30 to 50 hours. The benefit of having such a long half life is it can be taken in single doses once daily.

Amlodipine 5mg

5mg of Amlodipine is frequently used as the initial dose by patients. Your doctor may adjust this dose after reviewing your symptoms and deciding on whether you have made an improvement or not.

Amlodipine 10mg

10mg is required by most patients with angina. Your dosage may be increased to this strength if the lower dose was not effective in treating your symptoms.

How do i take Amlodipine tablets?

Usually, these tablets are taken once a day, orally, with a glass of water. While you can take it at any time during the day, it helps to take it at the same time every day. Please, follow the directions your doctor has given you.

You can take the tablet before or after eating. Make sure you swallow the medicine whole.

Do not double dose Amlodipine to make up for forgotten doses. If you miss a dose, take it as soon as you remember. However, if you do not remember until you are close to taking your next scheduled pill, then skip the dose and continue your course as normal.

Amlodipine Side Effects

All medicines come with the danger of side effects. It is rare to experience any side effects while taking a medicine, but you should be aware of any possible signs that you may be reacting to the medicine.

If you are worried about symptoms you have begun to exhibit you must contact your doctor for advice. If your symptoms are more severe, seek immediate medical help.

Common side effects of taking this medicine include:

  • Headache
  • Feeling dizzy
  • Increase in temperature or flushing of face
  • Heartbeat feeling more noticeable or pounding
  • Ankles swelling

Please note, this list is not exhaustive. For a list of more serious adverse effects which are associated with this medicine, please refer to the Side Effects tab on this page.

Lifestyle changes you can make to manage high blood pressure

There are a number of non-prescription alternatives that you can try to reduce your blood pressure.

According to, some of these changes include:

  • Eating a well balanced diet low in salt
  • Reduce your alcohol consumption
  • Exercise regularly
  • Manage stress
  • Maintain a health weight
  • stop smoking

Can I buy Amlodipine tablets online?

Yes, you can buy Amlodipine 5mg and 10mg tablets online form most UK pharmacies. Amlodipine is a prescription only medicine, so you will need to complete an online health consultation with a doctor or healthcare professional, this is so they are able to assess your condition and ensure that Amlodipine 5mg or 10mg tablets are the most suitable treatment option for your condition.

It is important to ensure that you are buying medicine online from a UK fully regulated pharmacy. To learn more about our company, team, medical professionals, and the licenses we hold, visit our about us page.

Amlodipine indications and dose

You can buy Amlodipine in 2.5mg, 5mg and 10mg strengths. Here at Medicine Direct, we sell the two most common strengths your doctor may prescribe, which are 5mg and 10mg; these are available as tablets.

All of our Doctor and Pharmacists follow NICE guidelines when prescribing Bendroflumetiazide.

How can I tell if Amlodipine is working?

If your doctor has prescribed you Amlodipine to treat high blood pressure, you may not exhibit any physical symptoms at all. Therefore, you may not feel any different when you use this medicine. This does not mean the medicine isn't working.

If you are using it to treat chest pains, these pains should cease and you should be able to exercise without any problems.

Amlodipine FAQ's

How long does amlodipine take to work?

This medicine begins to work as soon as you start taking it. However, it may take a couple of weeks to effectively lower your blood pressure.

How long will I need to take Amlodipine for?

If you are being treated for high blood pressure, you may need this medicine for the rest of your life. Amlodipine is a long term treatment plan.

Is Amlodipine safe to take for a long time?

Yes, amlodipine is intended for long term use and does not cause any long lasting side effects.

Can I stop taking it if my blood pressure is lower?

If you stop taking this medicine, even if your blood pressure is lowered, this might cause it to rise again. If your blood pressure is only managed by high blood pressure medicine, it is likely you will need to take this medicine for the rest of your life.

When should I take my tablets?

It is recommended to take your tablets at the same time every day, the exact time you take them (morning or evening) does not matter as long as you are consistently taking them at the same time every day.

Can I drink alcohol whilst taking amlodipine?

Yes, there is no known interaction between alcohol and amlodipine. However, alcohol may increase your risk of experiencing side effects. It is recommended to drink alcohol in moderation whilst taking amlodipine.

What is the price of Amlodipine in the UK?

Prices start from just £12.99 for 28 tablets.

Amlodipine Serious Side Effects

In rare cases, you may experience a serious side effect from taking this medication. Some of the more serious adverse effects include:

  • Severe stomach pain
  • Bloody diarrhoea
  • Nausea
  • Vomiting (this and the above can be a sign of pancreatitis)
  • Yellowing of your skin or eyes
  • Increase or new chest pain (have this looked at as soon as possible as this may be a sign of a heart attack)

If you experience any of these side effects, you should speak to your doctor as soon as possible.

Please note that this list is not exhaustive. For a more extensive list please see the patient information leaflet inside the medication box.

In rare cases, patients taking Amlodipine can suffer from a severe allergic reaction to the medicine.

If you experience any of the warning symptoms you MUST contact an emergency service such as 111 or 999 immediately. The signs of a severe allergic reaction are:

  • Developing a skin rash which is itchy, red, swollen, blistered or peeling
  • Your chest or throat feeling tight. This can also be displayed through wheezing.
  • Experiencing difficulty in breathing or talking
  • Your facial extremities become swollen i.e. you mouth, face, lips, tongue or throat.

Amlodipine Warnings and drug interactions

You must tell your doctor of all other medicines you are currently taking before being prescribed Amlodipine, as some medicines can interact negatively with it. Below are some of the medicines which are known to negatively affect your body while you take Amlodipine:

  • Some Antibiotics
  • Other medicines used to treat high blood pressure
  • Antifungal treatments
  • Medication used to treat HIV or HCV
  • Anti-epilepsy medicine
  • Medicine which suppresses your immune system
  • Some cholesterol-lowering medicine such as simvastatin if you take more than 20mg a day.

Taking other high blood pressure medication at the same time as Amlodipine could cause your blood pressure to lower too much and cause you to suffer from low blood pressure.

In addition to this, other medications unrelated to high blood pressure that may cause low blood pressure as a side effect should not be taken.

These include:

  • Ketoconazole
  • Itraconazole
  • Medications to treat HIV
  • Antibiotics such as rifampicin, erythromycin, clarithromycin
  • ST John’s wort
  • Verapamil
  • Diltiazem
  • Dantrolene
  • Tacrolimus
  • Simvastatin
  • Cyclosporine

Condition Interactions

  • Recent heart attack
  • Heart failure
  • Liver disease
  • You are elderly
  • Severe increase in blood pressure

For more on Amlodipine Drug Interactions

Pregnancy and breastfeeding 

Amlodipine in not usually prescribed to those who are pregnant or breastfeeding. Always speak to your doctor about taking this medication. Your doctor will asses the benefits and risks of taking Amlodipine during this time. 

Read more about taking Amlodipine during pregnancy and breastfeeding. 

Alcohol warning

It is possible to drink alcohol while taking Amlodipine. However, it may be counterproductive or cause negative effects to drink while taking the medicine. This is because alcohol can increase blood pressure which will lower the benefits and effect of the drug. By lowering the blood pressure, this can in turn cause you to have a headache, feel dizzy or tired. You should stop drinking alcohol while taking your course of Amlodipine if this happens to you.

Other Warnings

  • You are advised not to consume grapefruit juice while taking this medication.
  • Do not take this medication is you have hypotension (severe low blood pressure).
  • Do not use this medication if you suffer from aortic stenosis or cardiogenic shock.
  • Do not take this medication if you suffer from heart failure after a heart attack.

Amlodipine Ingredients

The main active ingredient within this medicine is: Alodipine besilate

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Written byHussain Abdeh MPharm: 2211840

Published on: 12/10/2020

Updated on: 24/06/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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