Lercanidipine Hydrochloride

  • Used to treat High Blood Pressure (Hypertension)
  • Works by widening blood vessels allowing blood to flow more freely
  • Also helps to prevent more serious risks associated with hypertension such as Heart Attacks

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Key Facts

  • High blood pressure is responsible for more than half of all stokes and heart attacks in the UK
  • 1 in 3 adults in the UK has high blood pressure (31% men and 26% women)
  • High blood pressure rarely has symptoms and is called the 'Silent Killer'
  • High blood pressure costs the NHS over £2.1 billion every year
  • 75,000 people died of High Blood Pressure in 2015

Source - Bloodpressureuk.org

What are Lercanidipine Hydrochloride Tablets?

Lercanidipine is an antihypertensive medicine, belonging to the dihydropyridine class of drugs known as calcium channel blockers (CCI).

Lercanidipine tablets are primarily used to lower blood pressure, however it also helps to prevent other complications such as heart disease, heart attacks and strokes.

Lercanidipine is a prescription only medicine and comes in tablet form, it is typically available to buy in doses 10mg and 20mg.

For more information about Lercanidipine, please visit the NHS website.

What is Lercanidipine used for?

Lercanidipine is one of the most widely prescribed medications to treat high blood pressure.

Calcium channel blockers can be used for several conditions ranging from hypertension, coronary spasm, angina pectoris, coronary artery disease, arrythmia (irregular heartbeat) and circulatory conditions such as Raynaud's disease, some calcium channel blockers can also be used to treat Migraines. Although not all Calcium Channel Blockers are recommended in the treatment of the above conditions. 

How does Lercanidipine Hydrochloride treat High Blood Pressure?

Calcium channel blockers inhibit the ion channels within the cells of the heart and blood vessels. Ion channels are responsible for absorbing calcium into the cells of different body tissues. 

In high blood pressure, blood vessels need calcium in order to restrict and contract, this forces more pressure on the heart and causes it to work harder to effectively pump blood around your body.

By inhibiting the ion channels, calcium channel blockers such as Lercanidipine reduce the absorption of calcium through the ion channels and allow your blood vessels to relax and widen, and as a result, lower blood pressure. 

If left untreated, high blood pressure can lead to damage of the blood vessels, heart attack or stroke. 

Taking Lercanidipine also helps to prevent debilitating conditions such a heart attack, stroke and heart disease.

Lercanidipine 10mg and 20mg tablets are a very effective once daily high blood pressure medicine, it is particularly successful at treating individuals with mild to moderate hypertension.

How to take Lercanidipine tablets

Swallow Lercanidipine whole with a glass of water.

You can take Lercanidipine at any time of day, although you should try to take it at around the same time every day.

Patients are advised to take the medicine fifteen minutes before eating a meal; fatty food can increase how much of this drug your body takes in, making you more susceptible to side effects.

You should also avoid drinking grapefruit juice or eating grapefruit products while taking this medicine as this could increase the concentration of Lercanidipine in your body and cause you to suffer adverse effects of the drug.

Lercanidipine dose

The lercanidipine dose you are prescribed will largely depend on your diagnosis and condition.


Indications and Dose

Mild to moderate Hypertension Initially 10mg, increased to 20mg daily if necessary
Source Nice

Who can take Lercanidipine Hydrochloride?

Lercanidipine should not be taken by children, it is only suitable for adults over the age of 18.

However, this drug is not suitable for all adults, and you are advised to inform your doctor before you start taking Lercanidipine if any of the below apply to you:

  • You have liver or kidney disease
  • You have heart disease or have recently had a heart attack
  • You have had an allergic reaction to Lercanidipine or any other medicines
  • You are pregnant or are trying to get pregnant
  • You are breastfeeding
  • You are currently taking any other medication (prescription or non-prescription) or herbal remedies
  • You suffer from diabetes mellitus
  • You have a weak immune system
  • You suffer with sinus syndrome

You are not advised to drink alcohol when taking Lercanidipine.

Lercanidipine 10mg and 20mg tablets side effects

As is the case with all medicines, taking Lercanidipine comes with the risk of certain side effects.

Not everyone will experience an adverse effect to this drug; if you do suffer any reactions, these often improve as your body gets used to Lercanidipine.

Common adverse reactions to this medicine include:

  • Flushing
  • Headaches
  • Coughing
  • Dizziness
  • Swollen ankles
  • A pounding heartbeat

If any of these effects bother you or persist for more than a few days, you are advised to seek medical help as quickly as possible.

This list is not exhaustive, for the full list of negative reactions, you should refer to the patient information leaflet which will accompany your medicine.

More serious adverse effects can be found under the Side Effects tab on this page. If you experience any of the more serious side effects, you should go to A&E or call 999 immediately.

Can you buy Lercanidipine online in the UK?

Yes, you can buy Lercanidipine 10mg and 20mg tablets online from most UK online pharmacies that specialise in high blood pressure management. To buy lercanidipine online you will need to complete an online consultation that will be reviewed by a doctor or healthcare professional to assess your condition to ensure the treatment is best suited for your condition.

It is important to ensure that you are buying medicine online from a UK fully regulated pharmacy. To learn more about our company, team, medical professionals, and the licenses we hold, visit our about us page.

Lercanidipine Dosage

You should always read the information leaflet fully before you take Lercanidipine. Always take your medicine exactly as instructed by your doctor or pharmacist.

This high blood pressure treatment is available in two different strengths, 10 mg and 20 mg.

Our pharmacist and prescribers follow NICE prescribing guidelines when prescribing Lercanidipine.

If you forget to take it

If you forget a dose of Lercanidipine, take it 15 minutes before your next meal. If you don't remember to take the medicine until the next day, you should just wait until it is time for your next dose.

Do not double dose this drug to make up for a missed dose; you should not take more than one dose in a 24 hour period as this could cause a low blood pressure.

If you do not see any improvement, you are advised to visit the doctor immediately.

Even if you feel better, you should not stop taking Lercanidipine, as you will still be getting the benefits this medicines provides.

Lercanidipine FAQ's

How long does Lercanidipine take to lower blood pressure?

Lercanidipine will start to work immediately after taking it, however it may take 2 to 3 weeks for it to successfully lower your blood pressure?

How long will i need to take Lercanidipine?

If your blood pressure is only managed by medicine, it is likely that you will need to take lercanidipine for the rest of your life. 

Is Lercanidipine safe to take for a long time?

Yes, in fact Lercanidipine is intended for long term use and also works best when taken for a long time. Taking this medicine for a long time will not cause any long lasting side effects.

Can I stop taking it if my blood pressure is lowered?

You should not stop taking lercanidipine even if your blood pressure is lowered. Stopping your treatment will likely cause your blood pressure to increase again.

Is Lercanidipine better than Amlodipine?

In clinical trials, Lercanidipine has been shown to be as effective at reducing blood pressure as Amlodipine. Both medicines are Calcium Channel Blockers and are equally as effective at lowering blood pressure.

Can I take painkillers such as Paracetamol whilst taking Lercanidipine?

Yes, paracetamol and Lercanidipine do not interact with each other and are safe to take together. However if taken incorrectly Paracetamol may increase blood pressure.

Is lercanidipine a Diuretic?

No, Lercanidipine is a Calcium Channel Blocker that lowers blood pressure by widening the blood vessels. Thiazide Diuretics reduce blood pressure by preventing water retention in the body.

When should I take my tablets?

You can take Lercanidipine in the morning or night, it does not matter what time of day you take your tablets. However you should always ensure that you are taking your tablets at the same time every day. 

Can I drink alcohol whilst taking Lercanidipine?

Yes, it is safe to drink alcohol in moderation when taking Lercanidipine.

What is the price of Lercanidipine in the UK?

Prices start from £19.99 for 28 tablets.

Lercanidipine Serious Side Effects

The common adverse effects of this medicine can be found on the main page.

Serious side effects to Lercanidipine are very rare, affecting less than one in every thousand people.

Nonetheless, you should seek immediate medical help if you experience any of the below:

  • Vomiting and dizziness
  • Swelling on hands, legs and feet
  • Severe headaches such as a migraine
  • Burning in the chest
  • Insomnia
  • Irritation to the skin

If you experience chest pains, you should call 111 or 999 immediately as this could be the symptoms of a heart attack.

In very rare cases, you may experience a severe allergic reaction to this drug. You should call 999 or go to A&E immediately if you have any of these symptoms:

  • Tightness in the chest or throat
  • Difficulty in speaking or breathing
  • A skin rash, which could be red, itchy, swollen, blistered or peeling
  • Wheezing
  • Swelling of the mouth, lips, face, tongue or throat

Always read the patient information leaflet that accompaines your medication for information on side effects.

Lercandipine Warnings and drug interactions

Lercanidipine is slower acting than older forms of dihydropyridines. While it has fewer adverse effects than most, it does have a relatively high risk of interacting with other drugs. It can interfere with the way certain medicines work.

Before you begin using this drug, you should inform your doctor if you are already taking any other blood pressure medicines, such as lisinopril or ramipril; combining these medications can have the effect of lowering your blood pressure too much.

If your blood pressure is lowered to much, it may result in your feeling dizzy or faint. If this feeling persists, you should seek medical attention as it may mean your dose needs to be changed.

If you are already taking any of these medicines, you should inform your doctor before you use Lercanidipine:

  • Medicines used to aid breathing, such as aminophylline or theophylline
  • Medicines used to treat HIV
  • The antibiotic erythromycin
  • Ciclosporin (a medicine used to prevent the immune system from overreacting)
  • The antifungal treatment itraconazole
  • Heart medicines such as digoxin
  • Epilepsy medicines, including carbamazepine, phenytoin, phenobarbital (phenobarbitone) or primidone

While there is little information available about using supplements and herbal remedies while using this medicine, you should still speak to your doctor or pharmacist before using any herbal or alternative remedies alongside Lercanidipine.

For more information on Drug Interations when taking Lercanidipine.

It is always worth noting that high blood pressure can be avoided or lessened by making changes to your lifestyle. By making simple changes such as stopping smoking, cutting down your alcohol consumption and eating a balanced diet with less fatty foods and sugar can make a huge impact on both your blood pressure and your health overall.

You should also be taking regular exercise and attempting to keep your stress levels to an absolute minimum.

These simple changes can mean that you may never require any form of medication to help you, or that you will not need to be on this drug for as long.

Preganacy and breastfeeding

Always speak to your doctor about taking this medication. Your doctor will asses the benefits and risks of taking Lercandipine during pregnancy and breastfeeing.

Learn more about taking Lercanidipine during preganacy and breastfeeding. 

Lercanidipine Ingredients

The main active ingredient within this medicine is: Lercanidipine hydrochloride

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

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Medically reviewed byHussain Abdeh MPharm: 2211840

Published on: 12/10/2020

Updated on: 23/06/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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