Naproxen Tablets (250mg & 500mg)

Buy Naproxen 250 & 500mg tablets for pain relief

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What are Naproxen tablets?

Naproxen tablets are a type of Non-steroidal anti-inflammatory drug, commonly knowns as NSAIDS. It is a short term treatment option used to treat mild to moderate pain and inflammation caused by a number of conditions. 

Naproxen tablets are available in a number of different strengths, ranging from 250mg to 500mg. Naproxen 500mg is typically the strongest strength of Naproxen available.

For more information, read our guide to Naproxen which explains everything you need to know.

What are Naproxen 250/500mg tablets used to treat?

Naproxen 500mg is usually prescribed when over the counter options such as paracetamol have failed to relieve symptoms. It is particularly effective at treating conditions where inflammation is also present.

It is used to treat the below conditions:

  • period pain 
  • arthritis
  • muscle/joint pain
  • back pain
  • Gout
  • Sprains and strains

In most cases, paracetamol is the most effective pain relief medicine for treating mild to moderate pain. Naproxen over the counter is available in lower doses, without a prescription, and may be a treatment option before moving onto the higher strength doses such as Naproxen 500mg and 250mg tablets.

Why are Naproxen tablets recommended for pain and inflammation?

Naproxen has been used to treat a variety of pain and inflammation conditions since 1976, it is considered the first line treatment for gout, musculoskeletal pain, inflammation, swelling and dysmenorrhea (period pain).

Naproxen has been shown to be very effective at treating a number of painful conditions by blocking the production of hormones that cause pain and inflammation at the source of an injury or infection.

Naproxen is considered to be a safer option when compared to stronger painkillers, particularly opioid based treatments such as codeine which can be highly addictive. 

How does naproxen work?

Like most anti-inflammatory drugs, naproxen works by reducing the hormones in your body that cause pain and inflammation.

Naproxen works by inhibiting the cyclooxygenase (COX) enzymes that help the body produce another natural chemical called prostaglandins. As part of the body’s natural healing process, prostaglandins are responsible for causing pain and inflammation at the source of an injury.

However, this natural healing response by the body can sometimes lead to excessive production of prostaglandins and contribute to unwanted pain and inflammation in certain parts of the body. Excessive production of prostaglandins is directly linked to conditions such as arthritis, painful menstrual cramps, and heavy menstrual bleeding.

By inhibiting the cyclooxygenase (COX) enzymes, the production of prostaglandins is decreased, as a result; pain and inflammation is also reduced.

Taking Naproxen tablets with other pain relief medicine

Naproxen must not be taken with any other type of NSAID, however it is safe to take Naproxen with paracetamol in certain circumstances.

Read our detailed guide on the differences between Naproxen, Paracetamol and Ibuprofen and if they can be taken together.

Who should not take Naproxen 250mg and 500mg tablets?

Naproxen tablets are not suitable for you if you have any of the below:

  • You are in the late stages of pregnancy
  • You have had bleeding or perforation in your stomach while previously taking a non-steroidal anti-inflammatory drug (NSAID)
  • You have severe liver, kidney, or heart problems
  • You have ever had, or currently have, any stomach problems, such as an ulcer or bleeding

Are Naproxen 250mg or 500mg tablets available over the counter?

You can buy lower doses of Naproxen over the counter, however Naproxen 500mg is a prescription only medicine and will need to be prescribed to you by a doctor or pharmacist. If you wish to buy naproxen over the counter, you will need to opt for a lower dose that is lower than the 500mg and 250mg prescription only doses.

Can you buy Naproxen tablets Online in the UK?

Yes, you can buy Naproxen 500mg and 250mg tablets online in the UK. You will be required to complete an online consultation where a doctor, pharmacist or prescriber will assess your condition. If you are looking to buy naproxen online, you should always ensure that the online pharmacy you are purchasing from is a fully licensed UK regulated pharmacy. 


Can NSAID's help period pain?

Naproxen in the treatment of acute gout

Naproxen 250mg and 500mg Dosage Instructions

All of our doctors and pharmacists follow the NICE guidelines when prescribing Naproxen.

The dosage you require will depend on the kind of pain you are taking Naproxen for, as well as your age and whether you have any pre-existing conditions.


Naproxen Dose

Rheumatic Diseases 500mg - 1g Daily in 1-2 divided doses
Pain and Inflammation (muscoskeletal disorders) 500mg followed by 250mg every 6-8 hours
Dysmenorrhoea (Period Pain) 500mg followed by 250mg every 6-8 hours
Gout 750mg followed by 250mg every 8 hours
Acute Migraine 500mg combined with Sumatriptan
Source NICE

How to take Naproxen Tablets

To make sure you don't suffer a stomach upset, Naproxen should be taken either with or after a meal.

Naproxen tablets should be swallowed whole with a drink of water. Do not crush or chew the tablets.

Is naproxen available to buy over the counter?

Yes, Naproxen is available over the counter in a lower dose, typically anything below 250mg can be purchased over the counter.

Can I buy Naproxen 500mg over the counter?

Naproxen 500mg is the highest dose of naproxen and cannot be purchased over the counter. Naproxen 500mg needs to be prescribed by a doctor or qualified pharmacist.

Can I buy Naproxen 250mg over the counter?

Naproxen 250mg requires a prescription from a doctor in order to be purchased. It can not be bought over the counter as it is classed as a prescription online medicine.

What is the over the counter equivalent of naproxen called?

Over the counter naproxen is available under a number of brand names, in the UK it is most commonly known as Feminax. Other popular pharmacies such as Boots or Superdrug may have their own branded version of over the counter naproxen.

How much does Naproxen 500mg cost?

In the UK the starting price for Naproxen 500mg is £12.99 for 28 tablets

Where can I buy Naproxen?

Naproxen can be bought from most community and online pharmacies in the UK, including However higher doses of Naproxen such as 250mg and 500mg need to be prescribed by a doctor.

How much is Naproxen 250mg to buy online?

The starting price for Naproxen 250mg is £11.99 for 28 tablets.

What is the difference between prescription and over the counter naproxen?

The main difference between the strength between the two. Over the counter naproxen is typically anything below 250mg, whereas prescription naproxen is 250mg and 500mg.

Naproxen side effects

Naproxen can cause irritation to the lining of the stomach and result in a gastrointestinal adverse effect, particularly in people who are taking Naproxen long term for a chronic condition.

If you have previously had or are at risk of peptic ulcer disease, a proton pump inhibitor such as Omeprazole or Lansoprazole may be prescribed to reduce the risk of gastrointestinal toxicity. 

For more information, our medical guide provides information on how to protect your stomach when taking Naproxen.

Common side effects of Naproxen include:

  • Feeling confused
  • Headaches
  • Ringing of the ears
  • Changes in vision
  • Feeling sleepy or tired
  • Feelings of dizziness
  • Rashes

You should speak to your doctor or pharmacist if any of these symptoms bother you or do not go away.

Our guide "naproxen side effects" covers more information on the common and serious side effects when taking naproxen.

Naproxen Warnings and drug interactions

Naproxen may interact with other medicines you are taking at the same time, which can hinder its effectiveness and increase your risk of experiencing adverse effects.

In particular, your doctor should be aware if you are currently taking any of the following medicines:

  • Any other NSAID's (nonsteroidal anti-inflammatory drug)
  • Any medications used for heart problems
  • Any medications for high blood pressure
  • Any medicines for arthritis treatment, such as methotrexate
  • Any steroids
  • Any blood thinning medicines, such as warfarin
  • Any medicines that make you urinate more frequently (diuretics)
  • Any antidepressants

If you have any questions as to whether Naproxen is suitable for you to use, please talk to your pharmacist before you start using it.

For more information on Naproxen Drug Interactions

Can you take Naproxen during pregnancy?

Unless prescribed, it is not recommended that pregnant women use this medicine, particularly if you are more than 30 weeks gone. Paracetamol is a recommended alternative to control pain during pregnancy

For more information about using Naproxen in pregnancy, visit the BUMPS (Best Use of Medicines in Pregnancy)

Can you take Naproxen whilst breastfeeding?

If you are currently breastfeeding, you should also tell your doctor before they prescribe you this medication. Alternative anti-inflammatory medicines may be more suitable for you to use while breastfeeding, such as ibuprofen.

Before you start using any form of painkiller, please inform your doctor if your baby was born premature, had a low birth weight, or any other underlying medical conditions.

Naproxen and Alcohol

It is generally considered safe to drink alcohol whilst taking Naproxen, however this should be done so in moderation. For more information on alcohol and naproxen, visit our guides page.

Naproxen Ingredients

The main active ingredient within this medicine is: Naproxen 250/500mg

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

How much does it cost to buy Naproxen tablets online in the UK?

Naproxen Tablets Quantity Buy Online UK Price
250mg 28 Tablets £11.99
  56 Tablets £22.99
  84 Tablets £30.99
  112 Tablets £44.99
500mg 28 Tablets £12.99
  56 Tablets £24.99
  84 Tablets £37.99
  112 Tablets £50.99

Written by: Hussain Abdeh MPharm: 2211840

Published on: 12/10/2020

Updated on: 07/05/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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  • 2 Online consultation Our Independent Prescribers will review your questions and assess your suitability for the medication.
  • 3 Receive your delivery Your medication is dispensed and delivered directly to you from our UK based Pharmacy.

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