Cyclizine Hydrochloride 50mg Tablets

  • Treats nausea and vomiting
  • Effective treatment for travel sickness
  • Fast acting in just 30 minutes

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Cyclizine at a glance:

Maxmum quantity per treatment: 100 tablets

Type Antihistamine
Prescribed for

Nausea, vomiting, vertigo, motion sickness

Side effects Drowsiness, dry mouth, headache, constipation, blurred vision
Available as Tablets
Dose 50mg
Price £21.99

What are Cyclizine Hydrochloride 50mg Tablets?

Cyclizine is an antihistamine medication that is used to treat nausea and vomiting, which can be caused by travel sickness, motion sickness, vertigo and other conditions.

It contains the active ingredient cyclizine hydrochloride, which works by blocking the receptors in the brain's vomiting centre.

How do Cyclizine Hydrochloride tablets work?

Taking Cyclizine 50mg tablets provides effective relief from nausea that comes with conditions such as motion sickness, vertigo, travel sickness, nausea caused by radiography or other medication, or following surgery that required general anaesthetic.

Cyclizine is an antihistamine that contains the active ingredient cyclizine hydrochloride. Antihistamines are effective at treating nausea and vomiting for a number of conditions, however; they should only be prescribed when the cause of vomiting is known.

Cyclizine works by blocking the receptors in the brain's vomiting centre, preventing them from receiving signals from the vestibular area. Doing this stops the vomiting centre from reacting and stops you from feeling nauseous.

How long does Cyclizine 50mg take to work?

Cyclizine hydrochloride can relieve the symptoms associated with the likes or travel sickness, morning sickness, vertigo and motion sickness within just 30 minutes.

By blocking the brain's vomiting centre receptors, one tablet can be effective for up to six hours. This allows you to get on with your day without feeling like you need to be sick.

How do I take Cyclizine?

Always take Cyclizine exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly and ask your doctor or pharmacist for further guidance if you still are not sure.

Do not take this medicine if you have recently consumed alcohol.

Do not exceed the stated dose.

Swallow Cyclizine tablets whole with a drink of water.

Cyclizine Dose

Symptoms Dose
Nausea Cyclizine 50mg up to 3 times daily
Vomiting 50mg Cyclizine up to 3 times daily
Vertigo Cyclizine 50mg up to 3 times daily
Motion sickness 50mg up to 3 times daily, tale 1-2 hours before departure
Indications and Dose NICE

Common Cyclizine side effects

Like all medicines, Cyclizine comes with the risk of side effects, although they will not affect everyone who takes it.

The below reactions affect more than 1 in 100 people who use this medicine; they are normally mild and go away on their own:

  • Headaches
  • Feeling drowsy
  • Constipation
  • Dry mouth, nose or throat
  • Blurred vision

Speak to your doctor if any of these reactions bother you or do not go away.

Please note, this list is not exhaustive. For information on more serious and rarer reactions, please refer to the Side Effects tab on this page.

More information on side effects can also be found in the patient information leaflet that accompanies your medicine.

Who can take Cyclizine hydrochloride 50mg tablets?

Cyclizine is suitable to be taken by most adults and children over the age of 6, but it is not suitable for everyone.

Speak to your doctor or pharmacist before you start taking Cyclizine if any of the following applies to you:

  • You have glaucoma
  • Bronchitis, COPD or any other breathing problems such as Asthma
  • You have ever had an allergic reaction to cyclizine hydrochloride or any other medicines in the past
  • You have high blood pressure
  • You suffer from a tumour called phaeochromocytoma
  • You have any liver problems
  • You suffer from urinary retention
  • You have an obstructive bowel condition, such as diverticulitis, Crohn's disease or colon cancer
  • You suffer from porphyria
  • You have an intolerance to, or cannot absorb certain sugars
  • You have been told that your heart does not work properly
  • You suffer from epilepsy
  • You are a man who has an enlarged prostate gland
  • You are due to have an allergy test (this medicine can affect the results, so you may need to stop taking it a few days before you have the test)

Do not take Cyclizine if you are allergic to cyclizine hydrochloride or any of the other ingredients in this medication (please refer to the Ingredients tab for full information).

Can you buy Cyclizine over the counter?

Cyclizine 50mg tablets are a prescription only medicine, meaning this medicine needs to be prescribed by a doctor or pharmacist. Usually with prescription only medicine there is an over-the-counter option available in a lower strength, however that is not the case with Cyclizine Hydrochloride. 

Can you buy Cyclizine online?

Yes, you can buy Cyclizine online in the UK, you will be required to complete an online questionnaire so that a doctor, pharmacist, or healthcare professional can assess your condition. Please note that to buy Cyclizine online in the UK, you need to be a UK citizen, we are unable to offer this medicine to anyone living outside of the UK.

Cyclizine alternatives

If Cyclizine is an unsuitable medication for you to take, do not worry. Other medicines are available which work in similar ways and will also provide effective relief from nausea in a similar length of time to Cyclizine.

There is not enough evidence to show that one medicine is more effective than another at relieving nausea symptoms, so you may need to take more than one before you find the best one for you.

Domperidone works in a similar way to Cyclizine. This medicine is prescription-only and can be used by people over the age of 12.

Alternatively, prochlorperazine is contained in a number of medicines. Generic Prochlorperazine tablets as well as the branded version, Stemetil are also available.

Cyclizine Hydrochloride 50mg Dosage and Directions

All of our pharmacists and prescribers will prescribe cyclizine as per the NICE guidelines and only for it's indicated uses.

What if I take too much?

Taking an extra dose of this medicine may cause: dry mouth, nose and throat, a fast or irregular heartbeat, blurred vision, a lack of balance or co-ordination, weakness, excitability, hallucinations, impaired judgement, disorientation, involuntary movement, muscle spasm, high temperature, difficulty breathing or convulsions.

Call 111 or go to A&E straight away if you take too much of this medication.

What if I forget to take it?

If you accidentally miss a dose of Cyclizine, just take the next dose at the usual time.

Never take a double dose of medicine to try and make up for missing a previous dose.

Always leave six hours between each dose.


Keep this medicine out of the sight and reach of children.

Do not store it in conditions above 25C and do not use after the expiry date, which can be found on the carton and label. The expiry date refers to the last day of the stated month.

Is Cyclizine addictive?

Developing an addiction to Cyclizine is unlikely, but you should only use it for as long as required.

How long does it take to work?

Cyclizine gets to work after around 30 minutes of being taken. You should notice the effects after around one hour and it will work for between four and six hours.

How does Cyclizine compare to other medicines?

Cyclizine is a drowsy antihistamine, meaning it can cause tiredness. This is not uncommon and other antihistamines can also have this effect, including promethazine and cinnarizine. Cyclizine is less likely to cause drowsiness compared to promethazine, although there is insufficient evidence to show which is more effective at relieving nausea. You may need to try more than one antihistamine to find the right one for you.

Can I drink alcohol with it?

You should avoid alcohol while taking Cyclizine as it can cause you to sleep very deeply. This may affect your breathing and cause difficulty in waking up.

Is it safe to take long-term?

Taking Cyclizine for long periods is not likely to cause any harm, although you should not take it for longer than you need to.

Can I take paracetamol with Cyclizine?

It is safe to take paracetamol with Cyclizine.

Can Cyclizine cause liver damage?

It is safe to take paracetamol with Cyclizine.

Are there any other ways to treat morning sickness?

Most pregnant women find that morning sickness goes away after between 16 and 20 weeks. Cyclizine is not officially approved as a morning sickness treatment, but it is considered to be beneficial and safe to take while pregnant. Lifestyle changes like eating cold food, drinking plenty of water and acupressure may also help to relieve morning sickness.

How long does Cyclizine take to wear off?

Cyclizine lasts for between four and six hours.

Cyclizine 50mg Side effects

Serious Side Effects

These side effects may occur in an unknown frequency:

  • Diarrhoea
  • Lack of coordination
  • Fast or irregular heartbeat
  • Heartburn
  • Loss of appetite
  • Feeling nervous, euphoric, weak or restless
  • Hallucinations
  • Difficulty sleeping
  • Difficulty urinating
  • Feeling or being sick
  • Ringing of the ears
  • Low blood pressure
  • High blood pressure
  • Pins and needles
  • Increased sensitivity to light
  • Seizures

Serious side effects of Cyclizine include:

  • Yellowing of the skin or the whites of the eyes (these may be signs of liver problems)
  • Any severe bleeding or bleeding that you cannot stop, such as nosebleeds or cuts that do not stop bleeding within 10 minutes
  • Muscle shaking or stiffness, or any unusual movements in your face or tongue

Seek medical attention if you get any of the above side effects.

Serious allergic reaction

In rare cases, you may suffer a serious allergic reaction to Cyclizine and require immediate treatment in hospital.

You must either go to A&E or call 999 straight away if you get any of the following:

  • You have swelling in your face, mouth, tongue, throat or lips
  • You have a skin rash that may have red, itchy, swollen, blistered or peeling skin
  • You are wheezing
  • You have tightness in your chest or throat
  • You are finding it difficult to breathe or speak

Please note, this is not an exhaustive list of side effects. For a complete list, please read the patient information leaflet, which will come with your medicine.

If you have any concerns about side effects, please discuss these with your doctor or pharmacist before you start taking this medication.

Cyclizine 50mg Warnings and drug interactions

Before you start taking Cyclizine tablets, please inform your doctor or pharmacist if you are taking any other medicine at the same time, whether it is for sickness or another condition entirely. This includes both prescription and non-prescription medication, herbal remedies, vitamins or supplements.

In particular, make sure your doctor or pharmacist is aware if you are taking any of the following:

  • Any medicines to treat depression, anxiety (such as propranolol) or sleeping problems
  • Any medicine that belongs to a group of medicines called anticholinergics
  • Any strong painkillers, such as pethidine

Please note that this list is not exhaustive, learn more about Cyclizine drug interactions.

Cyclizine and alcohol

Do not take these tablets if you have been drinking alcohol.

Cyclizine's anti-vomiting properties may increase the alcohol's toxicity levels.

Cyclizine during pregnancy and breastfeeding

Ask your doctor or pharmacist for advice before you start taking this medication if you are pregnant, think you might be pregnant, are trying to get pregnant or are breastfeeding.

Please refer to the patient information leaflet for full details on who this medication may not be suitable for. Please speak to your doctor or pharmacist for more information if you are not sure whether you can use Cyclizine.

Learn more about treating Nausea during pregnancy 

Cyclizine Hydrochloride Ingredients

The main active ingredient within this medicine is: Cyclizine hydrochloride

For a full list of the inactive ingredients, please read the Summary of Product Characteristics

Delivery Company Delivery Service Price Details
Royal Mail UK Delivery Standard UK Tracked £2.99 3 - 4 Working Day Delivery
DPD UK Next Day Delivery Next Day Delivery - Tracked £5.95 Order by 2pm (subject to Dr approval) Next Working Day Delivery
DPD UK Next Day Delivery Next Day Tracked Morning Delivery by 12:00pm £12.95 Next Working Day Morning Delivery by 12:00pm
DPD UK Next Day Delivery Tracked Saturday Delivery £9.95

Delivery specified for Saturday

Order Friday by 2pm (subject to Dr approval)

Please note that next day delivery to Northern Ireland, Scottish Highlands & Islands and British Isles cannot be guaranteed. Please contact our team for more information.

Written byHussain Abdeh MPharm: 2211840

Published on: 12/12/2020

Updated on: 11/05/2021

This content has been written by our Superintendent Pharmacist Hussain Abdeh and has been medically reviewed by our Pharmacist Sonia Khan

Hussain Abdeh Superintendent Pharmacist at Medicine Direct

Hussain Abdeh
MPharm: 2211840

Pharmacist Independent Prescriber

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